Elevated Erythrocyte-Bound IgG Value in Dogs with Clinical Babesia gibsoni Infection.

Adachi, Kozo; Tateishi, Mika; Horii, Yoichiro; Nagatomo, Hiroshi; Shimizu, Takamasa; Makimura, Susumu

doi:10.1292/jvms.56.757

Cited by 18 publications

(14 citation statements)

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“…It is known that cellular and humoral factors are involved in immunity to babesiosis (2,23,29). In the present study, a significant decrease (p < 0.05) in the percentage of CD4+ and CD8+ lymphocytes was observed in dogs from group 2.…”

Section: Discussionsupporting

confidence: 51%

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Changes in selected subpopulations of lymphocytes in dogs infected with Babesia canis treated with imidocarb

Adaszek¹,

Jarosz²,

Kalinowski³

et al. 2015

Tierarztl Prax Ausg K

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Section: Discussionsupporting

confidence: 51%

“…Adachi and colleagues (2) made similar observations in dogs with subclinical B. gibsoni infection. The dogs with subclinical B. gibsoni infection exhibited suppressed lymphocyte blastogenesis, which was paralleled in the reduced number of the cells in their blood (2,3). After using imidocarb the percentage of CD4+ lymphocytes increased.…”

Section: Discussionmentioning

confidence: 95%

Changes in selected subpopulations of lymphocytes in dogs infected with Babesia canis treated with imidocarb

Adaszek¹,

Jarosz²,

Kalinowski³

et al. 2015

Tierarztl Prax Ausg K

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“…This drug was reported to inhibit proliferation of Babesia canis from the canine-red blood cell-SCID mice [5]. Almost parasites of treated dogs during acute stage might be damaged or "inac- It is known that both cellular and humoral factors are involved in immunity to babesiosis [3,12,15]. Severe Babesial infection on the acute stage is well known to induce immune-depression [12].…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Subsets and Specific IgG Antibody Levels in Clindamycin-Treated and Untreated Dogs Experimentally Infected with Babesia gibsoni

Wulansari

Wijaya

Ano

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. This study was carried out to clarify the role of lymphocyte subpopulations and Babesia-specific antibody on the treatment of clindamycin in dogs infected with B. gibsoni. Ten beagle dogs were divided into two groups: an untreated group (5 dogs) and a clindamycin-treated group (5 dogs), which was administered clindamycin at 25 mg/ kg body weight, per os, q 12 hr from 7 days to 21 d ays post-infection (PI). On the acute stage of infection, clindamycin treatment resolved anaemia and other clinical findings. There were no significant differences between treated and untreated dogs either in parasitemia levels or Babesial IgG antibody levels. However, morphological changes that indicated degeneration in the majority of parasites were observed. The numbers of CD4 + showed a significant increase in treated dogs, especially after treatment. On the chronic stage, CD4 + cells maintained high level both of the treated and untreated dogs. Although parasitemia maintained low level, their relapses were occurred on the 49th day PI in treated dogs and on the 42nd and 63rd PI in untreated dogs. A rapid humoral antibody response was observed in treated dogs, however, lower humoral anti body responses in untreated dogs after relapses. The antibody levels of treated dogs were significantly higher than those of untreated dogs. These results suggested that clindamycin might not eliminate rapidly parasites from peripheral blood, but damage parasites, whic h might stimulate efficiently humoral and cellular immunity against Babesia infection, and result in an improvement of clinical conditions.

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“…Immune‐mediated hemolytic anemia (IMHA) may occur secondary to the inappropriate production of antierythrocyte membrane antibodies, and is assumed to occur with all Babesia spp . Elevated concentrations of antierythrocyte membrane antibodies and erythrocyte‐bound immunoglobulin G have been documented in dogs infected with B. gibsoni 60,61 . Continued hemolysis, despite appropriate anti‐babesial therapy, is the most prominent feature of this complication.…”

Section: Clinical Syndromes Associated With Babesia Infectionmentioning

confidence: 99%

Clinical management of canine babesiosis

Ayoob

Hackner

Prittie

2010

Journal of Veterinary Emergency and Critical Care

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Elevated Erythrocyte-Bound IgG Value in Dogs with Clinical Babesia gibsoni Infection.

Cited by 18 publications

References 0 publications

Changes in selected subpopulations of lymphocytes in dogs infected with Babesia canis treated with imidocarb

Changes in selected subpopulations of lymphocytes in dogs infected with Babesia canis treated with imidocarb

Lymphocyte Subsets and Specific IgG Antibody Levels in Clindamycin-Treated and Untreated Dogs Experimentally Infected with Babesia gibsoni

Clinical management of canine babesiosis

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