Elevated Cardiac Troponin T in Patients With Skeletal Myopathies

Abstract

Measured cTnT concentrations were chronically elevated in the majority of patients with skeletal myopathies, whereas cTnI elevation was rare. Our data indicate that cross-reaction of the cTnT immunoassay with skeletal muscle troponin isoforms was the likely cause.

Fourth Universal Definition of Myocardial Infarction (2018)

“…[23][24][25][26][27] Recent data suggest that the frequency of such elevations in the absence of ischaemic heart disease may be higher than originally thought. 28,29 cTnI and cTnT are the preferred biomarkers for the evaluation of myocardial injury, 12,21,22,30 and high-sensitivity (hs)-cTn assays are recommended for routine clinical use. 22 Other biomarkers e.g.…”

Cardiac Troponin - diagnostic problems and impact on cardiovascular disease

“…(3,4) Biotin, which is frequently used in supplements available over-the-counter, can further interfere with biotin-streptavidin based assaysand depending on the assay formulation (competitive versus sandwich methods), this can lead to falsely low (cTn) results (5)but rarely can also result in false-positives. Finally, skeletal muscle disease, such as most recently described by Schmid et al (6,7), can lead to an elevated cTnT concentration (but rarely cTnI), either through cross-reaction of the assay or, less convincing, a reexpression of the cardiac isoform in diseased skeletal muscle. Other than in the latter cohort, A c c e p t e d M a n u s c r i p t which should be clinically distinguishable, why do clinicians see many more patients with quantifiable cTn concentrations, who do not suffer an acute decompensation of a cardiovascular condition?…”

Non-coronarogenic causes of increased cardiac troponins in clinical practice

“…Экспрессию сердечных изоформ тропонинов в скелетных мышцах, о которых сообщали в некоторых работах, данные ученые не обнаружили. Наиболее вероятной причиной повышения hs-cTnT и hs-cTnT, по мнению авторов, была перекрестная реакция [68].…”