Fourth Universal Definition of Myocardial Infarction (2018)

Thygesen, Kristian; Alpert, Joseph S.; Jaffe, Allan S.; Chaitman, Bernard R.; Bax, Jeroen J.; Morrow, David A.; White, Harvey D.

doi:10.1161/cir.0000000000000617

Cited by 2,238 publications

(1,661 citation statements)

References 200 publications

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“…11,23,25 Despite being a potent candidate for diagnosing acute CAD, the diagnostic specificity of hs-cTnT may be affected by many other disorders, such as respiratory or renal failure, ischemic or hemorrhagic stroke, and septic shock. 26 Recent study even showed significant elevation of hs-cTnT in healthy individuals with family history of heart disease. 27 Specifically, the elevation of hs-cTnT levels is common in AIS patients and may trigger exhaustive diagnostic investigations and consultations.…”

Section: Discussionmentioning

confidence: 99%

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Sui

Liu

Luo

et al. 2019

Clinical Cardiology

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Background Elevated levels of cardiac troponin T (cTnT) have been associated with unfavorable outcomes in cardiac patients. However, no studies, to date, have discussed the prognostic value of high‐sensitivity cTnT (hs‐cTnT) in thrombolyzed patients with acute ischemic stroke (AIS). Hypothesis We hypothesized that elevated levels of hs‐cTnT would be associated with poorer clinical outcomes in AIS patients treated with intravenous tissue‐type plasminogen activator (IV tPA). Methods From January 2017 to February 2018, a total of 241 AIS patients treated with IV tPA within 4.5 hours of onset were recruited. On admission, patients were stratified into either normal or elevated hs‐cTnT groups according to a cutoff value of 14 ng/L. Multivariable logistic regression analyses were conducted to identify determinants of hs‐cTnT elevation and to detect whether elevated hs‐cTnT was associated with disability and/or mortality. Results In multivariable regression analysis, older age (P < .001) and stroke etiology (P = .024) were significantly associated with elevated hs‐cTnT levels. After adjusting for demographic and clinical characteristics, hs‐cTnT elevation was still significantly associated with 14‐day major disability (modified Rankin Scale (mRS) 3‐5, model 1, P = .019, odds ratio [OR] 2.677; model 2, P = .015, OR 2.834), 14‐day composite unfavorable outcome (mRS 3‐6, model 1, P = .005, OR 3.525; model 2, P = .003, OR 3.976), 30‐day mortality (P = .049, OR 4.545) and 90‐day mortality (P = .049, OR 3.835). Conclusions Elevation of hs‐cTnT at admission is associated with an increased risk of 90‐day mortality in AIS patients treated with IV tPA.

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Section: Discussionmentioning

confidence: 99%

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Sui

Liu

Luo

et al. 2019

Clinical Cardiology

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“…We compared the characteristics and outcome of MI patients before and after January 25, 2020. 4 Our hospital is a tertiary referral center, which serves a population of 530,000 in a region in Hong Kong. Since 2010, the hospital offers 24/7 primary percutaneous coronary intervention (PPCI)…”

Section: Methodsmentioning

confidence: 99%

Impact of coronavirus disease 2019 (COVID‐19) outbreak on outcome of myocardial infarction in Hong Kong, China

Tam

Cheung

Lam

et al. 2020

Cathet Cardio Intervent

102

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“…Diagnostic and/or of ≥1 mm (0.1 mV) in other contiguous chest leads or the limb leads. 21 Patients presenting more than 21 days after onset of symptoms were excluded.…”

Section: Identification Of Study Population and Patient Selectionmentioning

confidence: 99%

Design and rationale of the North Indian ST‐Segment Elevation Myocardial Infarction Registry: A prospective cohort study

Arora

Qamar

Gupta

et al. 2019

Clinical Cardiology

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ST‐segment elevation myocardial infarction (STEMI) is associated with increased mortality and morbidity. Although remarkable progress has been made in the management of STEMI in high‐income countries, contemporary data to evaluate processes and outcomes of STEMI care in India is limited. The North Indian ST‐segment elevation myocardial infarction (NORIN STEMI) registry is a prospective cohort study based at government funded and largely free of cost tertiary medical centers in New Delhi, India. These hospitals serve a large proportion of the patients with lower socioeconomic status presenting from multiple states in India, as many centers in these states lack adequate specialized cardiovascular care. The study has been approved by the Institutional Review Boards of each institution and informed consent has been obtained from study participants. The NORIN STEMI registry aims to provide important insights regarding contemporary risk factors profiles, practice patterns, and prognosis in patients with STEMI in an underserved population in North India. These findings may identify opportunities to improve the outcomes of patients with STEMI in India.

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Fourth Universal Definition of Myocardial Infarction (2018)

Abstract: The disclosure forms of all experts involved in the development of this Expert Consensus Document are available on the ESC website www.escardio.org/guidelines ESC Guidelines

Cited by 2,238 publications

References 200 publications

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Impact of coronavirus disease 2019 (COVID‐19) outbreak on outcome of myocardial infarction in Hong Kong, China

Design and rationale of the North Indian ST‐Segment Elevation Myocardial Infarction Registry: A prospective cohort study

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