Elevated C-Reactive Protein Levels in Overweight and Obese Adults

Visser, Marjolein; Bouter, Lex M.; McQuillan, Geraldine M.; Wener, Mark H.; Harris, Tamara B.

doi:10.1001/jama.282.22.2131

Cited by 2,119 publications

(1,488 citation statements)

References 41 publications

Supporting

126

Mentioning

1,263

Contrasting

Unclassified

Order By: Relevance

“…Several studies have shown that CRP is elevated in human obesity [36,37] and that it is correlated with indicators of adiposity [37][38][39][40][41]. These discrepancies may be explained taking into account several methodological aspects of the present study.…”

Section: Discussionmentioning

confidence: 76%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

View full text Add to dashboard Cite

Objectives: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothromboticproinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. Design and methods: Twenty-five men aged 49.6 Ϯ 12.7 yr (mean Ϯ SD) underwent whole-body air displacement plethysmography (Bod-Pod ® ) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. Results: Obese subjects had higher levels as compared to controls of BF (37.5 Ϯ 5.1 vs. 26.0 Ϯ 6.6, p Ͻ 0. Conclusions: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations.

show abstract

Section: Discussionmentioning

confidence: 76%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

View full text Add to dashboard Cite

show abstract

“…This is in agreement with the study by Hak et al 31 who also reported an independent association between WC and CRP levels. Visser et al 32 showed positive relationships between obesity (BMIX30.0 kg m À2 ), elevated WHR and CRP.…”

Section: Discussionmentioning

confidence: 98%

Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes

et al. 2005

View full text Add to dashboard Cite

Objective: To evaluate inflammation-and oxidative stress-related (OxS) background in former athletes in relation to overweight and abdominal obesity status. Design: Cross-sectional data from ongoing follow-up study. Subjects: A total of 60 middle-aged former athletes (46.677.5 years; 181.177.2 cm; 88.1712.9 kg) and 54 age-matched controls (48.177.3 years; 181.476.2 cm; 89.7714.4 kg). Measurements: Anthropometric characteristics, serum lipoproteins (CHOL, HDL-C, LDL-C, TG), oxidized LDL (oxLDL), diene conjugates (DC) and high-sensitive C-reactive protein (hsCRP). Information about the physical activity and other lifestyle variables were collected by the questionnaire. Results: Ex-athletes were characterized by significantly higher physical activity characteristics and lower CHOL and oxLDL in comparison with controls. Correlation analysis among ex-athletes revealed negative associations between all measured overweight data (body mass index, fat percentage, waist to hip circumferences and waist circumference (WC)), and current physical activity. Current physical activity was significantly related to OxS and inflammatory characteristics (oxLDL, DC and hsCRP) among the ex-athletes, but not among the control group. The most expressed positive correlations were found between WC, hsCRP, triglycerides (TG), DC and oxLDL in both study groups. Conclusion: Our study results suggest that there exists an independent (adjusted for potential confounders) association between overweight, abdominal obesity, and atherogenic inflammatory and oxidative stress markers in ex-athletes as well as in age-matched controls. Major findings of our study show that WC is the best correlate of hsCRP, oxLDL, DC and TG levels.

show abstract

“…To address this question, we used a benchmarking approach (Sechrest et al, 1996) These results have implications for neurodegenerative models of inflammation. Higher body mass has been consistently linked with increased inflammation (Visser et al, 1999 andWisse, 2004) as well as lower cognitive functioning (Benito-León et al, 2013, Cournot et al, 2006and Memel et al, 2016, and higher levels of inflammation predicts cognitive decline (Perry et al, 2007, Tegeler et al, 2016, Teunissen et al, 2003and Yaffe et al, 2003, but no previous studies have tested the associations body mass, inflammation, and cognitive decline in a single, integrated model. Once a robust link between a biometric risk factor, such as body mass, and an outcome of clinical interest is established, it essential to test the more proximal potential biological mechanisms that might help explain this association using mediation models that integrate the relevant biological intermediary into the pathways from risk factor to outcome (Miller et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…There are several pathways through which body mass might influence changes in cognitive functioning over time. For example, greater adipose tissue and body mass, for example, increases the production of proinflammatory cytokines tied to metabolic syndrome (Wisse, 2004) and greater body mass predicts greater leptin and insulin resistance, insulin dysregulation, and inflammation, all of which are associated with cognitive decline (Consondine et al, 1996;Al Hazzouri, Stone, Haan, & Yaffe, 2013;Greenwood & Winocur, 2005;Visser et al, 1999;Wisse, 2004). One potential biologically-mediated pathway that could explain the association between higher body mass and cognitive decline is inflammation.…”

Section: Body Mass Inflammation and Cognitionmentioning

confidence: 99%

Body mass and cognitive decline are indirectly associated via inflammation among aging adults

Bourassa

Sbarra

2017

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Inflammatory models of neurodegeneration suggest that higher circulating levels of inflammation can lead to cognitive decline. Despite established independent associations between greater body mass, increased inflammation, and cognitive decline, no prior research has explored whether markers of systemic inflammation might mediate the association between body mass and changes in cognitive functioning. To test such a model, we used two longitudinal subsamples (ns = 9066; 12,561) of aging adults from the English Longitudinal Study of Ageing (ELSA) study, which included two cognitive measures components of memory and executive functioning, as well as measurements of body mass and systemic inflammation, assessed via Creactive protein (CRP). Greater body mass was indirectly associated with declines in memory and executive functioning over 6 years via relatively higher levels of CRP. Our results suggest that systemic inflammation is one biologically plausible mechanism through which differences in body mass might influence changes in cognitive functioning among aging adults.

show abstract

Elevated C-Reactive Protein Levels in Overweight and Obese Adults

Abstract: Higher BMI is associated with higher CRP concentrations, even among young adults aged 17 to 39 years. These findings suggest a state of low-grade systemic inflammation in overweight and obese persons.

Cited by 2,119 publications

References 41 publications

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes

Body mass and cognitive decline are indirectly associated via inflammation among aging adults

Contact Info

Product

Resources

About