Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes

Abstract

Objective: To evaluate inflammation-and oxidative stress-related (OxS) background in former athletes in relation to overweight and abdominal obesity status. Design: Cross-sectional data from ongoing follow-up study. Subjects: A total of 60 middle-aged former athletes (46.677.5 years; 181.177.2 cm; 88.1712.9 kg) and 54 age-matched controls (48.177.3 years; 181.476.2 cm; 89.7714.4 kg). Measurements: Anthropometric characteristics, serum lipoproteins (CHOL, HDL-C, LDL-C, TG), oxidized LDL (oxLDL), diene conjugates (DC) and high-sensitive C-reactive protein (hsCRP). Information about the physical activity and other lifestyle variables were collected by the questionnaire. Results: Ex-athletes were characterized by significantly higher physical activity characteristics and lower CHOL and oxLDL in comparison with controls. Correlation analysis among ex-athletes revealed negative associations between all measured overweight data (body mass index, fat percentage, waist to hip circumferences and waist circumference (WC)), and current physical activity. Current physical activity was significantly related to OxS and inflammatory characteristics (oxLDL, DC and hsCRP) among the ex-athletes, but not among the control group. The most expressed positive correlations were found between WC, hsCRP, triglycerides (TG), DC and oxLDL in both study groups. Conclusion: Our study results suggest that there exists an independent (adjusted for potential confounders) association between overweight, abdominal obesity, and atherogenic inflammatory and oxidative stress markers in ex-athletes as well as in age-matched controls. Major findings of our study show that WC is the best correlate of hsCRP, oxLDL, DC and TG levels.

Correlation of drinking water nutritional element levels with body composition of women aged 55-70 years living in Batman province

“…It is also notified that oxidative stress is connected with irregular generation of adipokines, contributing to the progressing of the metabolic syndrome and, in turn, obesity might trigger systemic oxidative stress [28]. The oxidative damage is greater in persons with obesity and directly correlates with BMI and the body fat percentage, on the other hand, antioxidant defence markers are lower in respect to the quantity of body fat [29][30][31]. High-Se diets might induce the freeing of glucagon, promoting hyperglycaemia, or could cause overexpression of glutathione peroxidase-1 and other antioxidant selenoproteins, leading to insulin resistance and obesity [32].…”

Oxidative Stress, Inflammation And Apolipoprotein B (Apo B): Risk Indicators of Cardiovascular Disease in Non Diabetic Obese Males

“…(30) The increase in obesity associated oxidative stress(OS) is due to the presence of excessive adipose tissue itself, with the pre adipocytes and adipocytes as a source of proinflammatory cytokines, including TNF-α, IL-1and IL-6, resulting a state of chronic inflammation. In the present study, FOX assay which measures the total oxidative load in the plasma is significantly raised with BMI.…”

Reactive Oxygen Species and Oxidative Stress in Obesity

“…Obezitenin oksidatif stresi uyardığı bilinmektedir (18). Vücut yağ oranı ve beden kitle indeksi (BKİ) ile orantılı olarak obez bireylerde oksidatif zedelenme biyolojik belirteçleri daha yüksek bulunmuştur (19). Kronik aşırı beslenme, yüksek yağ-yüksek karbonhidrat içeren diyet, doymuş yağ asitleri ve trans yağ-ların fazla tüketilmesi, NADPH oksidazlardan süperoksit oluşumu, oksidatif fosforilasyon, gliseraldehid oksidasyonu, protein kinaz C (PKC) etkinliği ve poliolhekzamin yolu gibi mekanizmalarla oksidatif stres oluşturur (20,21).…”