Elevated body-mass index is associated with reduced white matter integrity in two large independent cohorts

Repple, Jonathan; Opel, Nils; Meinert, Susanne; Redlich, Ronny; Hahn, Tim; Winter, Nils R.; Kaehler, Claas; Emden, Daniel; Leenings, Ramona; Grotegerd, Dominik; Zaremba, Dario; Bürger, Christian; Förster, Katharina; Dohm, Katharina; Enneking, Verena; Leehr, Elisabeth J.; Böhnlein, Joscha; Karliczek, Greta; Heindel, Walter; Kugel, Harald; Bauer, Jochen; Arolt, Volker; Dannlowski, Udo

doi:10.1016/j.psyneuen.2018.03.007

Cited by 61 publications

(87 citation statements)

References 41 publications

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“…Cardiovascular risk factors are associated with decreases in DTI‐derived indices of WMI in the general population . One previous study found an association between BMI and DTI measures of WMI in BD, and the relationship has been reported in HV . In contrast, we did not find that BMI or other indices of cardiovascular function, including CBF, correlated with AD in BD.…”

Section: Discussioncontrasting

confidence: 86%

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

et al. 2019

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Objective:To compare white matter integrity (WMI) in bipolar disorder (BD) relative to healthy volunteers (HVs) and major depressive disorder (MDD). To determine the relationship of bipolar-specific differences in WMI to cerebral perfusion, body mass index (BMI), and blood pressure as indices of cardiovascular function.Methods: Thirty-two participants with BD, 44 with MDD, and 41 HV were recruited.All BD and MDD participants were in a major depressive episode, and all but 12 BD participants were medication-free. 64-direction diffusion tensor imaging (DTI) and arterial spin labeling (ASL) sequences were obtained. Tract-based spatial statistics (TBSS) on four DTI indices were employed to distinguish patterns of DTI in BD relative to HV and MDD groups. BMI, blood pressure, and medical histories were also obtained for the BD participants. Results:A cluster of lower axial diffusivity (AD) was found in BD participants in comparison to the HVs in the left posterior thalamic radiation, superior longitudinal fasciculus, inferior longitudinal fasciculus, fronto-occipital fasciculus, and internal capsule. Mean AD in the significant cluster was not associated with cerebral blood flow (CBF) in the region as measured by ASL, and was not associated with BMI or blood pressure. A cluster of lower AD was also found in the BD group when compared to MDD that had spatial overlap with the HV comparison. Conclusions:The results indicate a deficit of AD in BD when compared to MDD and HV groups. No association between AD values and either cerebral perfusion, BMI, or blood pressure was found in BD. K E Y W O R D S bipolar disorder, cerebral blood flow, diffusion tensor imaging, major depressive disorder, MRI How to cite this article: Lan MJ, Rubin-Falcone H, Sublette ME, et al. Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index. Bipolar

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Section: Discussioncontrasting

confidence: 86%

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

et al. 2019

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“…Another important finding of the present study is that associations between HbA1c and brain structure as well as between HbA1c and cognitive performance withstands correction for important covariates that are likely to covary with either HbA1c, cognition or brain structure. More precisely, our results appeared to be independent of age and BMI, two important sources of potential bias regarding the studied independent and dependent variables 28,48 . Furthermore, as could be expected the effect size of the observed associations decreased in analyses controlling for education.…”

Section: Discussionmentioning

confidence: 50%

“…The latter finding might be of particular relevance for the interpretation of our findings that are derived from healthy non-diabetic participants. Both metabolic disorder and inflammation in turn have repeatedly been linked to brain structural alterations 28,41-43 . More specifically, peripheral as well as CSF inflammatory markers have repeatedly been associated with impaired white matter microstructure in healthy subjects as well as in neuropsychiatric disorders 44–46 .…”

Section: Discussionmentioning

confidence: 99%

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Variation of HbA1c affects cognition and white matter microstructure in healthy, young adults

Repple

Karliczek

Meinert

et al. 2018

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The metabolic serum marker HbA1c has been associated with both impaired cognitive performance and altered white matter integrity in patients suffering from diabetes mellitus. However, it remains unclear if higher levels of HbA1c might also affect brain structure and function in healthy subjects. With the present study we therefore aimed to investigate the relationship between HbA1c levels and cognitive performance as well as white matter microstructure in healthy, young adults. To address this question, associations between HbA1c and cognitive measures (NIH Cognition Toolbox) as well as DTI-derived imaging measures of white matter microstructure were investigated in a publicly available sample of healthy, young adults as part of the Humane Connectome Project (n= 1206, mean age= 28.8 years, 45.5 % male). We found that HbA1c levels (range 4.1-6.3%) were significantly inversely correlated with measures of cognitive performance. Higher HbA1c levels were associated with significant and wide-spread reductions in fractional anisotropy (FA) controlling for age, sex, body-mass index and education. FA reductions were furthermore found to covary with measures of cognitive performance. The same pattern of results could be observed in analyses restricted to participants with HBA1c levels below 5.7%. The present study demonstrates that low-grade HbA1c variation below diagnostic threshold for diabetes is related to both cognitive performance and white matter integrity in healthy, young adults. These findings highlight the detrimental impact of metabolic risk factors on brain physiology and underscore the importance of intensified preventive measures independent of the currently applied diagnostic HbA1c cut-off scores.

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“…The neurobiological mechanisms behind this, however, remain largely elusive. Neuroanatomical studies suggest that obesity is associated with reductions in gray matter (GM) volume (García-García et al, 2018) and alterations in white matter (WM) microstructure (Repple et al, 2018;Zhang et al, 2018). Likewise, yet to a lesser extent, changes within these tissues were also reported in younger individuals (Kennedy, Collins, & Luciana, 2016; Ou, Andres, Pivik, Cleves, & Badger, 2015).…”

Section: Introductionmentioning

confidence: 99%

Alterations in brain network organization in adults with obesity as compared to healthy-weight individuals and seniors

Ottino‐González

Baggio

Jurado

et al. 2019

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Life expectancy and obesity rates have drastically increased in recent years. An unhealthy weight is related to longlasting biological deregulations that might compromise the normal course of development and jeopardize the so-called "successful aging". The aim of the current study was to test whether an obesity status could mimic the functional organization of an otherwise healthy aged brain. Thus, the current study included adults with (N = 32, mean age 34.5 ± 6.49) and without obesity (N = 34, mean age 32.7 ± 6.79) as well as adolescents with obesity (N = 30, mean age 15.3 ± 2.64) and normal-weight (N = 31, mean age 15.6 ± 2.60). A sample of stroke-free non-obese and non-demented seniors was also entered (N = 32, mean age 66.1 ± 7.43). Participants underwent resting-state MRI acquisition and graph-based measurements of segregation, integration and robustness (i.e., mean degree and strength) were calculated. Obesity in adults was followed by a broad pattern of loses in robustness when compared to healthy-weight adults and seniors, as well as increases in network segregation relative to elders. Differences in adolescents followed the same direction yet they did not survive multiple comparison adjustment. No interaction emerged when exploring the transition from childhood to adulthood accounting for body-weight status. Altogether, and yet more research is needed, an obesity status could negatively render network resilience and compromise the normal course of aging. Obesity | Aging | Maturation | Resting-state | Graph-theory

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Elevated body-mass index is associated with reduced white matter integrity in two large independent cohorts

Cited by 61 publications

References 41 publications

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

Variation of HbA1c affects cognition and white matter microstructure in healthy, young adults

Alterations in brain network organization in adults with obesity as compared to healthy-weight individuals and seniors

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