Elevated Atopic Comorbidity in Patients with Food Protein–Induced Enterocolitis

Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories

“…We ascertained the presence or absence of allergic conditions of interest (AD, IgE-FA, asthma, and AR) by using a combination of International Classification of Diseases (ICD) diagnosis codes, allergen information, and medication prescriptions, as described previously. 4,5,17 Conditions were identified by using the following ICD codes: AD (691.nn and L20.nn), IgE-FA (V15.0 [1][2][3][4][5], 995. [6][7], 995.7, Z91.01[0-3], Z91.018, and T78.1XXA), asthma (493.n and J45.nn), and AR (477.nn and J30.n).…”

Food protein‐induced enterocolitis syndrome triggered by egg yolk and egg white

“…1 The prevalence of acute FPIES due to hen's egg (HE-FPIES) is reported to be much less common than FPIES due to cow's milk, and the onset of symptoms usually occurs in infancy when eggs are introduced into the diet. 2,3 While previous reports have confirmed that patients with HE-FPIES react to whole eggs, whether they were reactive to egg white (EW) or egg yolk (EY) remains unclear. 4,5 This study aimed to specifically evaluate whether children diagnosed with HE-FPIES are reactive to EY or EW by performing oral food challenges (OFCs).…”

“…To the Editor, These diseases are therefore classified as interferonopathies. 3 The ISG sialic acid-binding immunoglobulin-like lectin 1 (SIGLEC1, sialoadhesin) is rapidly upregulated by inflammatory macrophages and modulates T-cell function and activation in animal models for various inflammatory diseases. 4 Monocytes from patients with SLE, another disease initiated and perpetuated by type-1-interferons, showed highest fold change expression levels of SIGLEC1, thus making monocytic SIGLEC1 expression a good indicator for type I interferon signature.…”

Food protein-induced enterocolitis syndrome: a large French multicentric experience

“…[7][8][9][10][11][12] The most frequent culprit food was fish in Greece 13 and Spain 10,14 rice in Australia [15][16][17] and the USA, 18 and oats in Taiwan. 19 Soy is frequently reported as a trigger food by North American, British, Australian and Israeli cohorts 4,17,20,21 and was infrequent in our population. Food habits, geographic origins, genetic factors, microbiota, and other environmental pre-or postnatal factors may explain these differences.…”

“…Its incidence is estimated between 0.015-0.7%. [1][2][3][4] In the absence of biomarkers, the diagnosis of FPIES is based only on clinical presentation. Acute FPIES is defined by typical repetitive vomiting starting 1 to 4 hours after ingestion of the culprit food, in association with at least 3 minor criteria according to the international consensus guidelines for the diagnosis.…”