Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories

Gabryszewski, Stanislaw J.; Chang, Xiao; Dudley, Jesse; Mentch, Frank; March, Michael; Holmes, John H.; Moore, Jason H.; Grundmeier, Robert W.; Hákonarson, Hákon; Hill, David R.C.

doi:10.1016/j.jaci.2020.06.026

Cited by 26 publications

(16 citation statements)

References 45 publications

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“…In this study, it led to the increase in AR only, while asthma symptoms were unaffected. This is consistent with the observation that the European ancestry of genetic polymorphisms is more often associated with the progression from eczema to rhinitis, rather than from eczema to asthma [ 89 ]. GWASs have shown that single allergic diseases and allergic multimorbidities have a different genetic base, which could mean that the classical “atopic march” represents only part of the pool of allergic patients with a common genetic basis [ 74 ].…”

Section: Discussionsupporting

confidence: 91%

“…Progression from one atopic disease is also geographically determined, as previously mentioned. On the other hand, the “atopic march” progression depends on the phenotypes of AD [ 89 ], which cannot be captured by an ISAAC questionnaire alone. Further gene–environmental studies and latent class analysis studies could offer a better explanation for these divergent findings.…”

Section: Discussionmentioning

confidence: 99%

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Divergent Trends in the Prevalence of Children’s Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia

et al. 2022

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Background: Previous studies have reported that the allergy epidemic in developed countries has reached its plateau, while a rise is expected in developing ones. Our aim was to compare the prevalence of allergic diseases among schoolchildren from the city of Zagreb, Croatia after sixteen years. Methods: Symptoms of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) and risk factors were assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. An allergic profile was determined by a skin prick test. Results: The prevalence of current, ever-in-a-lifetime and diagnosed AR of 35.7%, 42.5% and 14.9% and AD of 18.1%, 37.1% and 31.1% demonstrated a significant increase. The asthma prevalence has remained unchanged. The allergen sensitivity rate has remained similar, but pollens have become dominant. Mould and dog exposure are risks for asthma (OR 14.505, OR 2.033). Exposure to cat allergens is protective in AR (OR 0.277). Parental history of allergies is a risk factor in all conditions. Conclusion: Over sixteen years, the prevalence of AR and AD, but not of asthma, have increased. The proportion of atopy has remained high. The AR/AD symptom rise is probably a consequence of increased pollen sensitisation united with high particulate matter concentrations. The stable asthma trend could be a result of decreasing exposures to indoor allergens.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Divergent Trends in the Prevalence of Children’s Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia

et al. 2022

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“…2,5 However, in another recent study using an electronic medical records-based inception cohort in the Philadelphia region, Black children with AD were more likely to progress to asthma whereas White children were more likely to progress to AR. 10 Overall, the asthma progression appeared to occur sooner than the progression to AR. 10 The different findings among these studies could be related to the difficulty in making an asthma diagnosis in younger children, an issue that has been affected by changing diagnostic criteria, trends in diagnosis, and access to health care, as well as by the use of parental report for the AR diagnosis, which on its own, can also be challenging.…”

mentioning

confidence: 96%

“…10 Overall, the asthma progression appeared to occur sooner than the progression to AR. 10 The different findings among these studies could be related to the difficulty in making an asthma diagnosis in younger children, an issue that has been affected by changing diagnostic criteria, trends in diagnosis, and access to health care, as well as by the use of parental report for the AR diagnosis, which on its own, can also be challenging. 2 The consistency across studies is that there is an increased risk of asthma and AR in young children with AD, and in newer studies mostly from the United States, there is likely a difference in the frequency of AR and asthma in White versus Black children with AD.…”

mentioning

confidence: 96%

“…2 The consistency across studies is that there is an increased risk of asthma and AR in young children with AD, and in newer studies mostly from the United States, there is likely a difference in the frequency of AR and asthma in White versus Black children with AD. 2,5,6,10 However, recent US prevalence studies show that regardless of AD, Black children are more likely than White children to have asthma.…”

mentioning

confidence: 99%

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Atopic dermatitis and the atopic march: Considering racial and ethnic diversity in atopic disease progression

Takeshita¹,

Gupta

Zhu³

et al. 2022

Journal of Allergy and Clinical Immunology

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International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise

Damask

Roland

et al. 2023

Int Forum Allergy Rhinol

115

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Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence‐based findings and recommendation from the full document. Methods ICAR‐Allergic Rhinitis 2023 employed established evidence‐based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results ICAR‐Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion The ICAR‐Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

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Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories

Cited by 26 publications

References 45 publications

Divergent Trends in the Prevalence of Children’s Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia

Divergent Trends in the Prevalence of Children’s Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia

Atopic dermatitis and the atopic march: Considering racial and ethnic diversity in atopic disease progression

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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