Elevated atherogenic index and higher triglyceride increase risk of kidney function decline: a 7-year cohort study in Chinese adults

Abstract

Objective: This study explored whether lipid disorders or an elevated atherogenic index of plasma (AIP, a risk factor for cardiovascular diseases) could predict major kidney function decline. Methods: We conducted a retrospective 7-year cohort study of 3712 Chinese adults followed up between 2010 and 2017. Major kidney function decline was defined as a ! 30% reduction in the estimated glomerular filtration rate (eGFR) from baseline. Multivariable logistic regression models were used to evaluate the relationship between lipid profiles and major kidney function decline. Smoking habits, waist circumference, and physical activity were not assessed. Results: During the 7-year follow-up, 1.70% (n ¼ 63) of the participants developed major kidney function decline. After adjustment for potential confounders, the odds ratios (ORs) for developing eGFR decline with per standard deviation increase were 1.23 [95% confidence interval (CI): 1.06-1.43] for triglyceride and 2.55 (95% CI: 1.01-6.42) for AIP in all participants. Furthermore, in the stratified analysis, we found sex-related differences; triglyceride and AIP were only independently associated with the risk of eGFR decline in men (OR, 1.27, 95% CI: 1.08-1.48; OR, 3.98, 95% CI: 1.22-12.99, respectively). When the participants were divided into groups according to the baseline lipid status, association was observed only between abnormal AIP and eGFR decline (all p values < 0.05). Conclusion: Our findings suggest that a higher serum triglyceride level or an elevated AIP increases the risk of major kidney function decline in Chinese men with normal kidney function. Thus, assessment of AIP may help identify the risk of eGFR decline.

Predictive Factors for Target Organ Injuries in Hypertensive Individuals

“… 36 Additionally, TG can be a predictor of decline in renal function. 37 , 38 In our study, better glycemic control (HbA1c = 7.3%) had no influence on the presence of microalbuminuria, since this correlation has been found with higher HbA1c values (>10.5%). 39 …”

“…36 Additionally, TG can be a predictor of decline in renal function. 37,38 In our study, better glycemic control (HbA1c = 7.3%) had no influence on the presence of microalbuminuria, since this correlation has been found with higher HbA1c values (>10.5%). 39 Our results demonstrated that HDL-c, microalbuminuria ≥30 mg and the presence of carotid disease were associated with the development of stroke.…”

Study on the Interaction between the Characteristics of Retinal Microangiopathy and Risk Factors for Cerebral Small Vessel Disease

“…AIP is often used to assess the degree of atherosclerosis and to predict the severity of lipid metabolism disorders beyond individual lipids and/or TC/HDL-C ratios. Several studies have confirmed the association of AIP with metabolic syndrome, carotid plaque, and renal insufficiency, among others [ 25 , 26 ]. Additionally, recent studies have shown that AIP is a strong marker for predicting the risk of atherosclerosis and cardiovascular disease, and cardiovascular disease risk factors are related to the integrity of brain structures and cognitive impairment [ 27 ].…”

Lipid Parameters and the Development of Chronic Kidney Disease: A Prospective Cohort Study in Middle-Aged and Elderly Chinese Individuals

“…Firstly, decreased lipase and downregulation of lipoprotein receptors in patients with dyslipidemia and renal impairment affect the normal metabolism of very low density lipoprotein (VLDL) and chylomicrons, ultimately leading to an accumulation of TG and an increased risk of atherosclerotic complications [ 29 ]. Moreover, results of long-term cohort studies showed that higher serum TG levels increased the risk of severe decline in renal function, even in healthy individuals [ 30 , 31 ]. Based on the above evidence, TG is not only an important indicator for patients with advanced CKD, but also plays a role in predicting early CKD.…”