Elemental concentration analysis in brain structures from young, adult and old Wistar rats by total reflection X-ray fluorescence with synchrotron radiation

Serpa, R. F. B.; Jesus, Edgar Francisco Oliveira de; Anjos, M.J.; Carmo, Maria G. Tavares do; Moreira, Silvana; Rocha, Mariana C.; Martínez, Ana Maria Blanco; Lopes, Ricardo Tadeu

doi:10.1016/j.sab.2006.06.009

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…Brain 78,94,106 , cerebrum 21 , liver 8,21,78 , kidney 21,28,78 , spleen 21 , colon 36 , heart 78 , lung 21 , muscle 78 , breast 22 , skin 21 , hair 86 , blood 59,63,107 , serum 63,90 , bone-marrow fluid 35 , urine 44,59 , teeth 26 , bone 78,84 Dry sample Brain 27,45,[71][72][73] , liver 98,108 , muscle 108 , breast 55,56,109 , arteries 68 , uteri round ligaments 70 , hair 24,34,44,59 , fingernail 24 , bone 6 Acid digestion Wet sample Stomach 46 , liver 46,…”

Section: Wet Samplementioning

confidence: 99%

“…For liquid samples, such as body fluids, the measurement can be carried out directly 111 , 125 , 126 or after appropriate dilution of the sample 107 , 127 . Solid samples, both soft (such as organ tissues 106 , 128 ) and hard (e.g. bones 6 ) require sample preparation.…”

Section: Evaluation Of the Usefulness Of The Total Reflection X-ray Fmentioning

confidence: 99%

“…Serpa et al have studied the content of Al, P, S, Cl, K, Ca, Ti, Fe, Cu, Zn, Br and Rb in different parts of rat brain. They indicated how the concentrations of the elements change with the age of the animal 106 . In turn, Varga et al analysed content of Cr, Mn, Fe, Ni, Cu, Zn, Rb and Pb in the samples of liver biopsy taken from patients suffered from chronic diffuse liver disease 39 .…”

Section: Evaluation Of the Usefulness Of The Total Reflection X-ray Fmentioning

confidence: 99%

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The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

Planeta

Kubala‐Kukuś

Dróżdż

et al. 2021

Sci Rep

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The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composition of biological samples include Flame and Graphite Furnace Atomic Absorption Spectroscopy (F-AAS and GF-AAS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Each of these techniques has many advantages and limitations that should be considered in the first stage of planning the measurement procedure. Their reliability can be checked in the validation process and the precision, trueness and detection limits of elements belong to the most frequently determined validation parameters. The main purpose of this paper was the discussion of selected instrumental techniques (F-AAS, GF-AAS, ICP-OES and ICP-MS) in term of the achieved validation parameters and the usefulness in the analysis of biological samples. The focus in the detailed literature studies was also put on the methods of preparation of the biomedical samples. What is more based on the own data the usefulness of the total reflection X-ray fluorescence spectroscopy for the elemental analysis of animal tissues was examined. The detection limits of elements, precision and trueness for the technique were determined and compared with the literature data concerning other of the discussed techniques of elemental analysis. Reassuming, the following paper is to serve as a guide and comprehensive source of information concerning the validation parameters achievable in different instrumental techniques used for the elemental analysis of biomedical samples.

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Section: Wet Samplementioning

confidence: 99%

Section: Evaluation Of the Usefulness Of The Total Reflection X-ray Fmentioning

confidence: 99%

Section: Evaluation Of the Usefulness Of The Total Reflection X-ray Fmentioning

confidence: 99%

See 1 more Smart Citation

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

Planeta

Kubala‐Kukuś

Dróżdż

et al. 2021

Sci Rep

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“…Several tissues have been subjected to TXRF analysis so far, for example, tooth [50], bone [51], brain [52,53], thyroid tissue [54,55], placenta [56], liver [57], colon [58,59], breast [60] and lung [61]. The advantages brought about by the first approach are its applicability for nearly all types of tissues and the low background intensity which results in a good sensitivity for the analysis of transition metals.…”

Section: Tissuesmentioning

confidence: 99%

The Use of X‐Ray Techniques in Medical Research

Szalóki

Záray

Szoboszlai

2012

Analytical Techniques for Clinical Chemistry

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“…SR-TXRF analyses of the brains of Wistar rats were performed at the Synchrotron Light Brazilian Laboratory, Campinas, Sao Paulo, Brazil, by Serpa et al . It is important to know the spatial distribution and the local concentration of trace elements in tissues because trace elements are involved in a number of metabolic and physiological processes in the living organisms, and their deficiency and/or excess might lead to different metabolic disorders.…”

Section: Applicationsmentioning

confidence: 99%

X-ray Spectrometry

et al. 2008

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In this review, we focus on the most significant and essential progress in X-ray spectrometry (XRS) published during the period 2006-2007 covering the following topics: developments and improvements in the detection performance and instrumentation of X-ray techniques and X-ray optics, new quantification models in X-ray spectra and data evaluation, micro-X-ray fluorescence (µ-XRF) including 3D-XRF, imaging techniques such as tomography and holography methods for 2D or 3D imaging of microstructures, electron probe microanalysis (EPMA), total reflection X-ray fluorescence (TXRF), particle-induced X-ray emission (PIXE) analysis, and X-ray absorption spectrometry (XAS). Finally, different applications in each subfield of XRS are described. Since the previous review, the sections of µ-XRF and 3D-XRF are newly introduced.An international group of scientists published two overviews on XRS (1, 2) in the Journal of Analytical Atomic Spectrometry covering the period 2006-2007 in the principal field of XRS analytical spectroscopic methods and instruments. These review articles involve all the important sections of XRS in nine chapters: reviews, instrumentation, spectrum analysis, matrix correction and calibration, X-ray optics and microfluorescence, synchrotron radiation, TXRF, portable and mobile X-ray fluorescence (XRF), and online XRF and applications. In the present review, we use a different method of classifying the information published in the literature during the 2006-2007 period: detection, instrumentation (except detectors) and optics, quantification models and related fundamental data, tomography and holography methods as primary tools of X-ray imaging, TXRF, EPMA, PIXE, XAS, and a final chapter that reviews the application of these methods in geology, environmental research, industry, biology, and medicine.Two practically useful books were published in 2006-2007. The handbook entitled Practical X-ray Fluorescence Analysis was edited by five famous German researchers (3). Following the historical progress of XRF, the basic and recent developments in X-ray sources, X-ray optics, and X-ray detectors are described. Quantification, specimen preparation, and special configurations, such as TXRF and micro-XRF, and their applications in environ-* To whom correspondence should be addressed.

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Elemental concentration analysis in brain structures from young, adult and old Wistar rats by total reflection X-ray fluorescence with synchrotron radiation

Cited by 15 publications

References 16 publications

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

The Use of X‐Ray Techniques in Medical Research

X-ray Spectrometry

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