Elektronenmikroskopische Befunde zur Frage der Doppelmemlbranbildung des Herpes-simplex-Virus

Falke, D.; Siegert, R.; Vogell, W.

doi:10.1007/bf01242855

Cited by 73 publications

(21 citation statements)

References 8 publications

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“…The factors which initiate and control the extrusion of particles from the nucleus remain obscure. The occasional presence of vesicular ingrowths from the nuclear envelope, containing double-ringed virus particles, was noted earlier for herpes simplex virus (Falke, Siegert & Vogell, 1959) and for a human cytomegalovirus (Stern & Friedmann, 1960).…”

Section: Malignant Catarrhal Fever Virus 261supporting

confidence: 58%

Growth and Characterization of the Virus of Bovine Malignant Catarrhal Fever in East Africa

PLOWRIGHT¹,

Macadam

Armstrong

1965

Journal of General Microbiology

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SUMMARYA strain of bovine malignant catarrhal fever virus (MCF) recovered from the blood of a blue wildebeest was developed by passage in vitro to a stage where it could be propagated serially in primary thyroid cell cultures by inoculation of cell-free fluids. Released virus titres ranged from 103.8 to 105.8 50% tissue culture infectious doses/ml. This virus still caused fatal disease when inoculated to cattle, and was neutralized by antibody that appeared in the sera of cattle recovering from experimental infection. The principal cytopathic effects of the virus were the development of DNAcontaining intranuclear inclusions and syncytia ; the inclusions became increasingly basophilic as they matured. The cytopathic effects were inhibited in the presence of 5-iodo-2'-deoxyuridine (IUDR), and infectivity of the virus was abolished by treatment with ether or chloroform. Electron microscopy of inoculated cell cultures showed intranuclear, cytoplasmic and extracellular herpes-like virus particles. Suspensions of cell-free virus examined by negative-stain electron microscopy contained some particles of diameter 140 mp-220 mp, comprising an outer envelope and a central body or capsid; others consisted of only a naked capsid about 100 mp in diameter. MCF virus is evidently a member of the herpes group, and has particular affinities to a subgroup which contains the agents of varicella, herpes zoster and the cytomegaloviruses.

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Section: Malignant Catarrhal Fever Virus 261supporting

confidence: 58%

Growth and Characterization of the Virus of Bovine Malignant Catarrhal Fever in East Africa

PLOWRIGHT¹,

Macadam

Armstrong

1965

Journal of General Microbiology

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“…FAtKE et al, (i5), and MORGA~ et al, (11) discussed the possibility that the inner nuclear membrane is involved in the envelopment of herpes simplex virus, a finding, recently supported by DARLINGTON et al, (18). NII eta[., (17), on the other hand, suggested two modes of envelopment of herpes simplex: budding from the inner nuclear membrane as exemplified in the above-mentioned reports (11,15,18), and budding from the membrane of cytoplasmic vacuoles. These two possibilities were also discussed for varieella virus (16) and our own findings now support the previous reports (16,17).…”

Section: Fig17 a M A E R O P H A G E O B S E R V E D N E A R T H E mentioning

confidence: 93%

“…The mode of envelopment of herpes simplex virus (13,15,17,18) and varicella virus (10,16) has been already demonstrated. FAtKE et al, (i5), and MORGA~ et al, (11) discussed the possibility that the inner nuclear membrane is involved in the envelopment of herpes simplex virus, a finding, recently supported by DARLINGTON et al, (18).…”

Section: Fig17 a M A E R O P H A G E O B S E R V E D N E A R T H E mentioning

confidence: 95%

An electron microscopic study of varicella skin lesions

Kimura

Tosaka

Nakao

1972

Archiv f Virusforschung

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SummaryThe skin lesions of varicella were studied by electron microscopy. Singlemembrane particles were the only type'of viral particles present in the nucleus. Two modes of viral envelopment were observed; budding from the inner nuclear membrane, and budding from vacuole membranes of the cytoplasm. Tubular, filamentous structures, probably an aberrant form of the virus, were often observed in affected nuclei. Nuclear bodies were frequently found and showed abnormal structures in the nuclei of cells near the intraepidermal vesicles. Strands, inclusion-like structures, probably composed of degenerated nuclear materials, were seen in some instances in the cytoplasm. Virions were frequently included in phagosomes of epidermal or dermal maerophages.

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“…A typical he1~esvirion consists of (a) a core containing a linear double stranded DNA which, in some instances, forms a torus [84,163], (b) an icosadeltahedral capsid approximately 100 to 110 nm in diameter containing 12 pentameric and 150 hexameric capsomeres, the latter with a hole running down the long axis [81,231,147]; (c) an amorphous, sometimes asymmetric material which surrounds the capsid and which was designated as the tegument [188]; and (d) a membrane designated as the envelope, in which viral glycoprotein spikes are embedded and project from its surface [4,12,75,78,99,159,160,208,209,211].…”

Section: Properties Of Herpesviruses: Definition Of the Family Herpesmentioning

confidence: 99%

The familyHerpesviridae: an update

Roizmann

Desrosiers

Fleckenstein

et al. 1992

Archives of Virology

480

208

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Elektronenmikroskopische Befunde zur Frage der Doppelmemlbranbildung des Herpes-simplex-Virus

Cited by 73 publications

References 8 publications

Growth and Characterization of the Virus of Bovine Malignant Catarrhal Fever in East Africa

Growth and Characterization of the Virus of Bovine Malignant Catarrhal Fever in East Africa

An electron microscopic study of varicella skin lesions

The familyHerpesviridae: an update

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