Electrostatic self-assembly of pFe3O4 nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds

Yang, Wenjing; Zhong, Yan; He, Chongxian; Peng, Shuping; Yang, Youwen; Qi, Fangwei; Feng, Pei; Shuai, Cijun

doi:10.1016/j.jare.2020.04.009

Cited by 62 publications

(40 citation statements)

References 58 publications

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“…An undeniable fact was that RGO still contained a large amount of oxygen-containing functional groups. These negatively charged oxygen-containing functional groups was able to interact with cell membrane phospholipids and proteins by means of electrostatic interaction, hydrogen bonding, p-p stacking, etc [ 73 ]. Hence, the RGO-contained scaffold with enhanced bioactivity was favorable for cells adhesion and growth as compared with Zn scaffold, which overshadowed the negative effect of accelerated degradation.…”

Section: Resultsmentioning

confidence: 99%

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Yang

Cheng

Peng

et al. 2021

Bioactive Materials

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143

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Zinc (Zn) possesses desirable degradability and favorable biocompatibility, thus being recognized as a promising bone implant material. Nevertheless, the insufficient mechanical performance limits its further clinical application. In this study, reduced graphene oxide (RGO) was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing. Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold. On one hand, the enhanced strength was ascribed to (i) the grain refinement caused by the pinning effect of RGO, (ii) the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix, and (iii) the Orowan strengthening by the homogeneously distributed RGO. On the other hand, the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3, which activated more slip systems and provided more space to accommodate dislocation. Furthermore, the cell test confirmed that RGO promoted cell growth and differentiation. This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair.

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Section: Resultsmentioning

confidence: 99%

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Yang

Cheng

Peng

et al. 2021

Bioactive Materials

Self Cite

143

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“…In addition, the Fe 3 O 4 nanoparticles in the scaffold have a large surface area to volume ratio. Uniform dispersion in the scaffold may show more contact surface area, thus providing more attachment sites for cell attachment [ 59 ]. However, the Fe 3 O 4 nanoparticles are nanomaterials, and previous studies have indicated that the nanomaterials may cause some potential adverse effects on cells and organs of the human body [ 60 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe3O4 nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe3O4 nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe3O4 presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe3O4 nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe3O4 scaffold with good magnetic properties is of great potential for bone tissue engineering applications.

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“…On the one hand, SLM and SLS can fabricate personalized implants similar to nature bone in the defect site, according to the predefined external shape and internal architecture. The interconnected porous structure can provide space for the in-growth of new bone, hence accelerating the osseointegration process [136]. On the other hand, the high energy laser makes an extremely high heating rate and a short holding time, which can further shorten the processing time [137].…”

Section: Selective Laser Sintering/meltingmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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As two promising biomaterials for bone implants, biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity; while bioceramics are known for good biocompatibility or even bioactivity but limited by their high brittleness. Biocermets, a kind of composites composing of bioceramics and biomedical metals, have been developed as an effective solution by combining their complementary advantages. This paper focused on the recently studied biocermets for bone implant applications. Concretely, biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase percentages. Their characteristics were systematically summarized, and the fabrication methods for biocermets were reviewed and compared. Emphases were put on the interactions between bioceramics and biomedical metals, as well as the performance improvement mechanisms. More importantly, the main methods for the interfacial reinforcing were summarized, and the corresponding interfacial reinforcing mechanisms were discussed. In addition, the in vitro and in vivo biological performances of biocermets were also reviewed. Finally, future research directions were proposed on the advancement in component design, interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

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Electrostatic self-assembly of pFe3O4 nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds

Cited by 62 publications

References 58 publications

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

Advances in biocermets for bone implant applications

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