Electrostatic field-assisted alignment of electrospun nanofibres

Théron, A.; Zussman, Eyal; Yarin, Alexander L.

doi:10.1088/0957-4484/12/3/329

Cited by 752 publications

(478 citation statements)

References 17 publications

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“…The solvent evaporates on the way and the jet solidifies to form a non-woven fibrous mat on the grounded collector [46,47]. An electrically grounded rotating drum can be used as the collector to achieve preferred orientation if desired [48,49].…”

Section: Electrospinningmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,199

819

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Section: Electrospinningmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,199

819

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“…Many devices applying nanofibrous structure require well aligned and ordered arrangement, such as those in microelectronics and photonics, nanoreinforcement, and tissue engineering [5][6][7][8]. Application of electrospun fibres in tissue engineering is strongly related to its potential in resembling the morphology of extracellular matrix in the body [9].…”

Section: Introductionmentioning

confidence: 99%

“…Several attempts also have been proposed to improve fibre directionality, mainly related to the collector design. A wheel-like bobbin with tapered edge produced parallel arrays of nanofibres focused on the sharp edge of the wheel [5]. Using conductive plates with gap introduction, uniaxial fibres were formed in the gap region and oriented perpendicularly to the gap edges [8,19].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Anindyajati

Boughton

Ruys

2015

MATEC Web of Conferences

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Abstract. Electrospinning is a technique that can produce fibres in the nanoscale range. This process is useful for many applications, including fabrication of fibrous scaffolds for fibrocartilage tissue engineering. For this application, cell attachment and tissue development is influenced by fibre morphology and mechanical properties. This electrospinning study investigated the influence of rotating collector design on morphology and mechanical properties of electrospun polycaprolactone fibre. The experiment employed 4 mandrel designs: 1) full surface of aluminium; 2) with gap feature; 3) with gap feature and teflon support; 4) with gap feature and tape support. The highest elastic modulus was obtained from mandrel with gap and tape support, which was 24.6 MPa and significantly higher compared to fibres acquired from other collector designs. Fibre diameter attained was identical across the different collectors, ranging from 0.5 -2 µm. Gap introduction showed enhanced alignment in the resultant fibre. It can be concluded that fibre alignment and tensile properties can be improved by simply modifying the collector design. This improved fibre mat can be developed as a biomaterial for fibrocartilage tissue engineering scaffolds.

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“…The more important aspects are the optimum structure distribution or model of fibre distribution. The optimum model guides researchers to make better adjustments for better manufacturing [12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

A novel model of optimum nanofibre distribution in nanofibre scaffold structure by genetic algorithm method

Semnani

2013

Journal of Experimental Nanoscience

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Recently, nanofibre scaffolds have been used in prosthesis such as blood vessels, ligaments and skin. The optimum nanofibre distribution in the scaffold leads to uniform spreading in the tissue structure, regularity and smoothness on the tissue surface and in suitable tensile properties of prosthesis. This study presents a novel optimum model of nanofibre distribution in the scaffold structure by using the genetic algorithm method. The optimised model was considered in nanofibre scaffold samples prepared from polycaprolactone. Surface characteristics and tensile tests were performed to tissue samples. All of the experimental results strongly confirmed the results of optimised structural model of nanofibre scaffolds.

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Electrostatic field-assisted alignment of electrospun nanofibres

Cited by 752 publications

References 17 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

A novel model of optimum nanofibre distribution in nanofibre scaffold structure by genetic algorithm method

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