Electrostatic Assembly/Disassembly of Nanoscaled Colloidosomes for Light‐Triggered Cargo Release

Abstract

Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos.

Plasmonic Colloidosomes as Three‐Dimensional SERS Platforms with Enhanced Surface Area for Multiphase Sub‐Microliter Toxin Sensing

“…This denotes that our plasmonic colloidosome is able to enhance aR aman signal by more than 10 6 ,i n comparison to the signal in the absence of the plasmonic Ag nanocube shell. In addition, our plasmonic colloidosomes also show a3 000-fold superior SERS activity relative to ac oumarin-containing decane suspension of the same mass of Ag nanocubes ( Figure S19), where the latter only exhibits an analytical enhancement factor of 210 4 .T he general Raman enhancement of > 10 6 provided by plasmonic colloidosome originates from both the intense and dense SERS hotspot in the closely packed Ag nanocube of the colloidosomes shells, and also from the large 3D area imparted by plasmonic colloidosomes.…”

Colloidal Crystals from Microfluidics

“…Li et al conducted drug delivery experiments using colloidosomes. Colloidosomes were composed of silica colloidal particles modified with negative charge (NBSN‐1) and positive charge (NBSN‐2) (Figure d) . The inside of the colloidosomes were loaded with Nile Red dye.…”

“…Colloidosomes were composed of silica colloidal particles modified with negative charge (NBSN-1) and positive charge (NBSN-2) (Figure 12d). [182] The inside of the colloidosomes were loaded with Nile Red dye. Under UV light, the group on the surface of NBSN-2 fractured, making the surface charge became negative.…”

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

“…[66] To start with, they employed light-sensitive nitrophenylene-alkoxysilane derivatives to modify the silica nanoparticles with positive and negative charges (NBSN-1 and NBSN-2). [66] To start with, they employed light-sensitive nitrophenylene-alkoxysilane derivatives to modify the silica nanoparticles with positive and negative charges (NBSN-1 and NBSN-2).…”