Electrospun tubular scaffolds: On the effectiveness of blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐<i>co</i>‐3‐hydroxyvalerate)

Gaudio, Costantino Del; Fioravanzo, Lara; Folin, Marcella; Marchi, Fabiana; Ercolani, Enrico; Bianco, Alessandra

doi:10.1002/jbm.b.32756

Cited by 42 publications

(31 citation statements)

References 46 publications

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“…Significant differences exist even in how researchers analyze their samples based on shape. Some researchers use a tubular shape—representing a macroscopic view of a blood vessel – while others employ a square sample . Within these studies there has been some analysis as to how different properties affect the maximum attained SRS force.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic microstructural reorganization during suture retention strength evaluation of electrospun vascular scaffolds

et al. 2015

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Suture retention strength (SRS) is commonly used as a measure the ability of sutures to adhere implants to surrounding tissue. While SRS is widely employed, surprisingly its effects on graft microstructure have not been characterized. This is particularly germane to the broad utilization of electrospun implants in tissue engineering. These implants need to retain their initial nanoscale topography while simultaneously preserving clinically critical mechanical properties. We examined the suture-driven microstructural deformation of polycaprolactone electrospun to form both square and tubular SRS samples. The impact of fiber orientation (generally parallel or random orientation, orthogonally aligned) on the SRS of these vascular tissue equivalents was analyzed and compared to native and decellularized porcine vasculature. The initial state of the fiber clearly dictates the overall efficiency of scaffold utilization. SRS values for as-spun fibers at a thickness of 300 μm were found to be in the range of 1.59-4.78 N for the three orientations. Unexpectedly, random fibers provided the optimal SRS values based on both resistance to suture motion and the percentage of scaffold involvement. A "V-shaped" failure morphology is observed for both electrospun scaffolds and native tissue during SRS testing. Post-test fiber alignment in the tensile direction was visible in all initial fiber orientations similar to that of native tissue. These findings are significant as they allow us to employ new, counterintuitive biomimetic design criteria for nanofiber-based scaffolds in which reliable mechanical integration with the surrounding tissues via suture-based methods is important. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1525-1534, 2016.

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Section: Discussionmentioning

confidence: 99%

Biomimetic microstructural reorganization during suture retention strength evaluation of electrospun vascular scaffolds

et al. 2015

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“…The mechanical properties of PHBV/PCL blends showed increasing ductility of the blend samples with an increasing amount of PCL. 37 Del Gaudio et al 38 developed PCL/PHBV blends using vascular grafts and compared the biological performance with the parent polymers. In their study, rat cerebral endothelial cells were used to assess the biological performance of these grafts.…”

Section: Pha Modification Via Blendingmentioning

confidence: 99%

“…However, pure PHBV was less suitable for these cells, which may be related to the different mechanical features. 38 …”

Section: Pha Modification Via Blendingmentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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“…To improve attachment of cells, mainly PCL was blended with multiple synthetic or natural polymers such as collagen, elastin, or gelatin with different blend ratios [63 -66] . Recently, del Gaudio produced PCL scaffolds blended with hard Brought to you by | Kungliga Tekniska Högskolan Authenticated Download Date | 7/6/15 6:41 AM poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, and evaluated these scaffolds regarding their mechanical properties and attachment and growth of rat cerebral endothelial cells [63] . They were able to demonstrate that PCL and PCL/PHBV scaffolds promoted attachment and migration of rat cerebral endothelial cells.…”

Section: Vascular Tissue Engineeringmentioning

confidence: 99%

Nanotechnologies in tissue engineering

Bigdeli

Lyer

Detsch

et al. 2013

Nanotechnology Reviews

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As an interdisciplinary field, tissue engineering (TE) aims to regenerate tissues by combining the principles of cell biology, material science, and biomedical engineering. Nanotechnology creates new materials that might enable further tissue-engineering applications. In this context, the introduction of nanotechnology and nanomaterials promises a biomimetic approach by mimicking nature. This review summarizes the current scope of nanotechnology implementation possibilities in the field of tissue engineering of bone, muscle, and vascular grafts with forms on nanofibrous structures.

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Electrospun tubular scaffolds: On the effectiveness of blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)

Cited by 42 publications

References 46 publications

Biomimetic microstructural reorganization during suture retention strength evaluation of electrospun vascular scaffolds

Biomimetic microstructural reorganization during suture retention strength evaluation of electrospun vascular scaffolds

Polyhydroxyalkanoates: opening doors for a sustainable future

Nanotechnologies in tissue engineering

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