Electrospun Polyvinylpyrrolidone/Soy protein nanofibers enriched with curcumin-loaded ZIF-8 nanoparticles: Synthesis and evaluation for wound healing application

Al-Musawi, Mastafa H.; Mahmoudi, Elham; Mohammadzadeh, Vahid; Asadi, Kaveh; Аlmajidi, Yasir Q.; Ramezani, Soghra; Ghorbani, Marjan

doi:10.1016/j.colsurfa.2023.132131

Cited by 14 publications

(11 citation statements)

References 63 publications

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“…Notably, the spectra still have a unique absorption peak of AL at 1662 cm –1 . Similar phenomena have been found in previous studies. , In conclusion, the absence of novel characteristic peaks throughout the loading procedure serves as compelling evidence that no novel substances emerged during the entirety of the loading process.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, the stretching vibration peak of the hydroxyl group in AL@ZIF-8 can be observed in the FTIR of AL@ZIF-8, but its intensity is significantly lower than that of the phenol hydroxyl group in AL, indicating that the hydrogen bonds are formed between the hydroxyl group of AL and functional groups such as amines and carboxyl groups on the surface of ZIF-8. 36 Notably, the spectra still have a unique absorption peak of AL at 1662 cm −1 . Similar phenomena have been found in previous studies.…”

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confidence: 99%

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Ammonia-Responsive Colorimetric Film of Phytochemical Formulation (Alizarin) Grafted onto ZIF-8 Carrier with Poly(vinyl alcohol) and Sodium Alginate for Beef Freshness Monitoring

Zhang,

Zhang

et al. 2024

J. Agric. Food Chem.

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In this study, we devised a photothermally stable phytochemical dye by leveraging alizarin in conjunction with the metal–organic framework ZIF-8 (AL@ZIF-8). The approach involved grafting alizarin into the microporous structure of ZIF-8 through physical adsorption and hydrogen-bonding interactions. AL@ZIF-8 significantly enhanced the photostability and thermostability of alizarin. The nanoparticles demonstrate substantial color changes in various pH environments, showcasing their potential for meat freshness monitoring. Furthermore, we introduced an intelligent film utilizing poly(vinyl alcohol)-sodium alginate-AL@ZIF-8 (PA-SA-ZA) for detecting beef freshness. The sensor exhibited a superior water contact angle (52.34°) compared to the alizarin indicator. The color stability of the film was significantly enhanced under visible and UV light (ΔE < 5). During beef storage, the film displayed significant color fluctuations correlating with TVB-N (R 2=0.9067), providing precise early warning signals for assessing beef freshness.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Ammonia-Responsive Colorimetric Film of Phytochemical Formulation (Alizarin) Grafted onto ZIF-8 Carrier with Poly(vinyl alcohol) and Sodium Alginate for Beef Freshness Monitoring

Zhang,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…Therefore, these materials were not only biocompatible but also increased cellular growth and proliferation due to their high nutritional value, which is in good agreement with previous reports. [34][35][36]60 Given Cur's established antitumor properties, one might find the increased cell viability in the presence of >50 μg/mL of SPIA@Cur perplexing. However, it is important to note that the Cur IC 50 value for A549 and MCF7 cell lines is 40 μM.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…For wound healing purposes, soybean protein is a promising alternative to animal proteins. Due to its high bioactivity and nutritional effects, it encourages tissue growth and eliminates ethical and cultural concerns, with no risk of transmitting infections . The potential of soy protein-based biomaterials for mimicking the extracellular matrix (ECM), increasing cellular activity, and reducing inflammation in wounds has made them attractive candidates for wound healing purposes.…”

Section: Introductionmentioning

confidence: 99%

In Situ Nanoencapsulation of Curcumin in Soy Protein Isolate Amyloid-like Aggregates for Enhanced Wound Healing

Arghavani,

Behjati Hosseini,

Moosavi-Movahedi

et al. 2024

ACS Appl. Mater. Interfaces

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The importance of amyloid nanofibrils made from food proteins is rising in diverse fields, such as biomedicine and food science. These protein nanofibrils (PNFs) serve as versatile and sustainable building blocks for biomaterials, characterized by their high β-sheet content and an ordered hydrogen bond network. These properties offer both stability and flexibility, along with an extreme aspect ratio and reactive functional groups. Plant-derived amyloid nanofibrils, such as soy protein isolate (SPI) PNFs, are increasingly favored due to their affordability and sustainability compared with animal proteins. This study aimed to explore the formation and application of SPI amyloid-like aggregates (SPIA) and their nanoencapsulation of curcumin (Cur) for biomedical purposes, particularly in wound healing. Under specific conditions of low pH and high temperature, SPIA formed, exhibited an amyloid nature, and successfully encapsulated Cur, thereby enhancing its stability and availability. Spectroscopic and microscopic analyses confirmed structural changes in SPIA upon the incorporation of Cur and the fabrication of SPIA@Cur. The obtained results indicate that in the presence of Cur, SPIA forms faster, attributed to accelerated SPI denaturation, an increased nucleation rate, and enhanced self-assembly facilitated by Cur's hydrophobic interactions and π−π stacking with SPI peptides. In vitro studies demonstrated the biocompatibility, biodegradability, and antioxidant properties of SPIA@Cur along with controlled release behavior. In vivo experiments in male Wistar rats revealed that both SPIA and SPIA@Cur significantly accelerate wound closure compared with untreated wounds, with SPIA@Cur showing slightly better efficacy. The histological analysis supported enhanced wound healing, indicating the potential of SPIA@Cur for biomedical applications.

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“…A polylactic acid-based electrospun composite material loaded with curcumin was reported to achieve antibacterial properties against E. coli and S. aureus [ 19 ]. An electrospun polyvinylpyrrolidone and soy protein composite encapsulating curcumin nanoparticles was reported to possess hemocompatibility and antipathogenic activities, and wound-healing potentials [ 20 ]. The general trend of curcuminoid-loaded electrospun products was to achieve local effects like antibacterial [ 21 , 22 , 23 ] and wound healing [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

Lin,

Li,

Huang

2024

Foods

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Electrospun/sprayed fiber films and nanoparticles were broadly studied as encapsulation techniques for bioactive compounds. Nevertheless, many of them involved using non-volatile toxic solvents or non-biodegradable polymers that were not suitable for oral consumption, thus rather limiting their application. In this research, a novel electrospun lipid–polymer composite (ELPC) was fabricated with whole generally recognized as safe (GRAS) materials including gelatin, medium chain triglyceride (MCT) and lecithin. A water-insoluble bioactive compound, tetrahydrocurcumin (TC), was encapsulated in the ELPC to enhance its delivery. Confocal laser scanning microscopy (CLSM) was utilized to examine the morphology of this ELPC and found that it was in a status between electrospun fibers and electrosprayed particles. It was able to form self-assembled emulsions (droplets visualized by CLSM) to deliver active compounds. In addition, this gelatin-based ELPC self-assembled emulsion was able to form a special emulsion gel. CLSM observation of this gel displayed that the lipophilic contents of the ELPC were encapsulated within the cluster of the hydrophilic gelatin gel network. The FTIR spectrum of the TC-loaded ELPC did not show the fingerprint pattern of crystalline TC, while it displayed the aliphatic hydrocarbon stretches from MCT and lecithin. The dissolution experiment demonstrated a relatively linear release profile of TC from the ELPC. The lipid digestion assay displayed a rapid digestion of triglycerides in the first 3–6 min, with a high extent of lipolysis. A Caco-2 intestinal monolayer transport study was performed. The ELPC delivered more TC in the upward direction than downwards. MTT study results did not report cytotoxicity for both pure TC and the ELPC-encapsulated TC under 15 μg/mL. Caco-2 cellular uptake was visualized by CLSM and semi-quantified to estimate the accumulation rate of TC in the cells over time.

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Electrospun Polyvinylpyrrolidone/Soy protein nanofibers enriched with curcumin-loaded ZIF-8 nanoparticles: Synthesis and evaluation for wound healing application

Cited by 14 publications

References 63 publications

Ammonia-Responsive Colorimetric Film of Phytochemical Formulation (Alizarin) Grafted onto ZIF-8 Carrier with Poly(vinyl alcohol) and Sodium Alginate for Beef Freshness Monitoring

Ammonia-Responsive Colorimetric Film of Phytochemical Formulation (Alizarin) Grafted onto ZIF-8 Carrier with Poly(vinyl alcohol) and Sodium Alginate for Beef Freshness Monitoring

In Situ Nanoencapsulation of Curcumin in Soy Protein Isolate Amyloid-like Aggregates for Enhanced Wound Healing

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

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