Electrospun polyurethane fibrous membranes of mimicked extracellular matrix for periodontal ligament: Molecular behavior, mechanical properties, morphology, and osseointegration

Watcharajittanont, Nattawat; Putson, Chatchai; Pripatnanont, Prisana; Meesane, Jirut

doi:10.1177/0885328219874601

Cited by 25 publications

(3 citation statements)

References 45 publications

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“…Electrospinning may produce highly porous polymer structures of natural or synthetic origin with an increased surface area such as gelatin nanofibers, collagen and polycaprolactone (PCL) [ 120 ]. Several research groups have used electrospinning to fabricate scaffolds for alveolar bone regeneration, implant integration, gingival tissue and periodontal ligament regeneration [ 121 , 122 , 123 , 124 , 125 , 126 , 127 ]. This technique produces meshes with an increased surface area and high porosity promoting cell attachment.…”

Section: Scaffolds In Bte/rmmentioning

confidence: 99%

Recent Advances in Scaffolds for Guided Bone Regeneration

Valamvanos,

Dereka,

Katifelis

et al. 2024

Biomimetics

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The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool. This article presents a critical consideration in scaffold’s design and development while also providing information on various fabrication methods of these nanosystems. Their utilization as delivery systems will also be mentioned.

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Section: Scaffolds In Bte/rmmentioning

confidence: 99%

Recent Advances in Scaffolds for Guided Bone Regeneration

Valamvanos,

Dereka,

Katifelis

et al. 2024

Biomimetics

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“…A lot of recent research has focused on tissue scaffolds for tissue regeneration after musculoskeletal surgery, especially bone scaffolds [1][2][3]. Bone scaffolds are designed to promote bone tissue regeneration by enhancing the biological functions osteogenesis, conduction, induction, and integration [4,5].…”

Section: Introductionmentioning

confidence: 99%

Bone-mimicking scaffold based on silk fibroin incorporated with hydroxyapatite and titanium oxide as enhanced osteo-conductive material for bone tissue formation: fabrication, characterization, properties, and in vitro testing

Watcharajittanont,

Tabrizian,

Ekarattanawong

et al. 2023

Biomed. Mater.

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Bone-mimicking scaffolds based on silk fibroin (SF) mixed with hydroxyapatite nanoparticles (HA NPs) and titanium oxide (TiO2) nanoparticles were created as materials for bone formation. Six scaffold groups were fabricated: S1 (SF), S2 (Silk + (HA: TiO2; 100: 0)), S3 (Silk, (HA: TiO2; 70: 30)), S4 (Silk + (HA NPs: TiO2; 50: 50)), S5 (Silk + (HA: TiO2; 30: 70)), and S6 (Silk + (HA NPs: TiO2; 0:100)). Scaffolds were characterized for molecular formation, structure, and morphology by Fourier transform infrared spectroscopy, element analysis, and X-ray diffraction. They were tested for physical swelling and compressive modulus. Scaffolds were cultured with MC3T3 and tested in vitro to evaluate their biological performance. The results showed that scaffolds with HA and TiO2 demonstrated molecular interaction via amide I and phosphate groups. These scaffolds had smaller pore sizes than those without HA and TiO2. They showed more swelling and higher compressive modulus than the scaffolds without HA and TiO2. They exhibited better biological performance: cell adhesion, viability, proliferation, alkaline phosphatase activity, and calcium content than the scaffolds without HA and TiO2. Their porous walls acted as templates for cell aggregation and supported synthesis of calcium secreted from cells. S3 were the most suitable scaffolds. With their enhanced osteo-conductive function, they are promising for bone augmentation for oral and maxillofacial surgery.

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“…11,12 PU has been used widely for biomedical applications owing to its proper mechanical properties, biocompatibility, and processing versatility. [13][14][15] There is also an overwhelming number of studies showing that PU is a favorable choice for the fabrication of electrospun wound dressing, but is limited by its imperfect biocompatibility, mechanical, and antibacterial properties. Additives to PU fibers have demonstrated the improvement in terms of mechanical performance, biocompatibility, and hydrophilicity.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of polyurethane/graphene oxide for skin wound dressing and its in vitro characterization

et al. 2020

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Electrospinning polyurethane has been utilized as skin wound dressing for protecting skin wounds from infection and thus facilitating their healings, but also limited by its imperfect biocompatibility, mechanical and antibacterial properties. This paper presents our study on the addition of graphene oxide to electrospinning polyurethane for improved properties, as well as its in vitro characterization. Polyurethane/graphene oxide wound dressing was electrospun with varying amount of graphene oxide (from 0.0% to 2.0%); and in vitro tests was carried out to characterize the wound dressing properties and performance from the structural, mechanical, and biological perspectives. Scanning electron microscopy and Fourier-transform infrared spectroscopy were used to confirm the interaction between graphene oxide particles and polyurethane fibers, while the scanning electron microscopy images further illustrated that the wound dressing was of a porous structure with fibre diameters depending on the amount of graphene oxide added; specifically, 20 to 180 nm were for composite polyurethane/graphene oxide fibers and 600 to 900 nm for pure polyurethane. Our results also revealed that the hydrophilicity and swelling properties of the wound dressing could be regulated by the amount of graphene oxide added to the polyurethane/graphene oxide composites. Mechanical, antibacterial, and cytotoxicity properties of the composite polyurethane/graphene oxide wound dressing were examined with the results illustrating that the addition of graphene oxide could improve the properties of the electrospun wound dressing. Combined together, our study illustrates that electrospinning polyurethane/graphene oxide composite is promising as skin wound dressing.

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Electrospun polyurethane fibrous membranes of mimicked extracellular matrix for periodontal ligament: Molecular behavior, mechanical properties, morphology, and osseointegration

Cited by 25 publications

References 45 publications

Recent Advances in Scaffolds for Guided Bone Regeneration

Recent Advances in Scaffolds for Guided Bone Regeneration

Bone-mimicking scaffold based on silk fibroin incorporated with hydroxyapatite and titanium oxide as enhanced osteo-conductive material for bone tissue formation: fabrication, characterization, properties, and in vitro testing

Electrospinning of polyurethane/graphene oxide for skin wound dressing and its in vitro characterization

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