Electrospun polycaprolactone/silk fibroin nanofibrous bioactive scaffolds for tissue engineering applications

Nazeer, Muhammad Anwaar; Yilgör, Iskender

doi:10.1016/j.polymer.2019.02.023

Cited by 77 publications

(43 citation statements)

References 65 publications

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“…In addition, the preparation of PCL/fiber composites by electrospinning technique provides an added enhancement on the ultimate mechanical properties due to its facile preparatory set-up and the formation of well-dispersed nanofibers with uniform average diameter throughout the PCL matrix. Electrospun PCL/filler composites have shown exclusive improvement in various mechanical properties, namely: flexural strain, tensile strain, tensile stress, Young's modulus and thermomechanical strength [56,58,70,79]. These mechanical properties are closely associated with the biomedical treatments, particularly in the implantation of artificial bone and muscle tissues regeneration, on the account that the stiffness of the electrospun PCL/fiber composites is relatively appropriate for in-vivo applications [72].…”

Section: Mechanical Properties Of Electrospun Pcl and Its Compositesmentioning

confidence: 99%

“…In addition, the blending of PCL with other synthetic polymers with different properties for the preparation of polymer blends, after which the fabricated fillers can be introduced to the blends to afford PCL/blends composites with tremendous enhancement of the mechanical properties [79,83,84]. Table 4 summarizes the different solvent systems for electrospinning of PCL/filler nanocomposites and their mechanical properties [27,52,56,58,[62][63][64]67,72,80,82,[84][85][86][87][88][89]. Of all mechanical properties presented, modulus, tensile and strain, there was a discernible increase when the nanoclay is introduced at 1% and 5%.…”

Section: Mechanical Properties Of Electrospun Pcl and Its Compositesmentioning

confidence: 99%

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Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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Section: Mechanical Properties Of Electrospun Pcl and Its Compositesmentioning

confidence: 99%

Section: Mechanical Properties Of Electrospun Pcl and Its Compositesmentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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“… 1 − 4 Recently, silk fibroins have been gaining attention, particularly in the field of regenerative medicine for use as scaffolds and membranes in tissue repair. 5 − 7 …”

Section: Introductionmentioning

confidence: 99%

Characterization of Ground Silk Fibroin through Comparison of Nanofibroin and Higher Order Structures

et al. 2020

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Silk fibroin, a biodegradable component of silk, is increasingly used for various applications and studied intensively. Recently, a technique for preparing nanofibers without using chemicals has been gaining attention from the environmental impact and safety perspectives. This study focuses on the structure observation of ground silk fibroin (GF) prepared using a grinding method, which is a physical nanofibrillation method. The fabricated nanofiber samples were examined in detail using the X-ray diffraction (XRD), differential scanning calorimetry (DSC), micro Raman spectroscopy, and atomic force microscopy (AFM) techniques. The nanofibrillated structures were observed in both GF and regenerated silk fibroin (RF) samples prepared using the conventional method. As results, AFM images showed that the nanofibril diameter of GF was about 1.64 nm and that of RF was about 0.32 nm. Methanol treatment induced a structural transition from a random coil to a β-sheet for the RF film, but it had no effect on the GF film. Thus, it is suggested that the grinding method provides not only ultrafine silk fibroin nanofibers without using toxic reagents but also resistance to reagents such as methanol.

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“…The presence of the hydroxyl group in the solvent transferred the random coil structure of SF to β‐sheet crystals. Therefore, increasing the amount of SF in composite, it raised the formation of silk II (β‐sheet) which result in more crystallinity followed by higher water uptake resistance 43,44 …”

Section: Resultsmentioning

confidence: 99%

“…Therefore, increasing the amount of SF in composite, it raised the formation of silk II (β-sheet) which result in more crystallinity followed by higher water uptake resistance. 43,44 On the contrary, SrCO 3 decreased WCA leading to a decline in the water uptake percentage. Therefore, the presence of nanoparticles showed an indirect effect on water absorption.…”

Section: Physical Characterizationmentioning

confidence: 99%

Novel bilayer electrospun poly(caprolactone)/ silk fibroin/ strontium carbonate fibrous nanocomposite membrane for guided bone regeneration

Etemadi

Mehdikhani

Poorazizi

et al. 2020

J of Applied Polymer Sci

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In this study, a thin layer with a thickness of about 120 μm of poly(caprolactone) (PCL) was fabricated by electrospinning method. Then, a fibrous nanocomposite composed of PCL/silk fibroin/strontium carbonate (PCL/SF/SrCO3) was electrospun on the prepared layer. Then, they were characterized. The mechanical properties, water uptake, degradation rate, wettability, porosity, and bioactivity of the electrospun membrane were scrutinized in vitro. Cytotoxicity of the samples was assessed by using osteoblast‐like cells (SAOS‐2) and L929 fibroblasts. Moreover, the cell adhesion, alkaline phosphatase (ALP) activity, and calcium deposition through alizarin red staining were conducted. Results revealed that the bilayer structure doubled the optimum mechanical properties and the addition of SrCO3 up to 15%–20% increased ALP activity, calcium deposition, and bioactivity. According to the results, the nanofibrous bilayer membrane containing 20 wt% SrCO3, 20 wt% SF, and 60 wt% PCL was chosen as the optimum sample. Therefore, this membrane could be applied in guided bone regeneration (GBR).

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Electrospun polycaprolactone/silk fibroin nanofibrous bioactive scaffolds for tissue engineering applications

Cited by 77 publications

References 65 publications

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Characterization of Ground Silk Fibroin through Comparison of Nanofibroin and Higher Order Structures

Novel bilayer electrospun poly(caprolactone)/ silk fibroin/ strontium carbonate fibrous nanocomposite membrane for guided bone regeneration

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