Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing

Abstract

Due to the rise in bacterial resistance, the antibacterial extractions from Chinese herbs have been used more frequently for wound care. In this work, baicalin, an extraction from the Chinese herb Scutellaria baicalensis, was utilized as the antibacterial component in the poly(ε-caprolactone)/MXene (PCL/Ti3C2TX) hybrid nanofibrous membranes for wound dressing. The results revealed that the presence of Ti3C2TX aided in the diameter reduction of the electrospun nanofibers. The PCL hybrid membrane containing 3 wt% Ti3C2TX nanoflakes and 5 wt% baicalin exhibited the smallest mean diameter of 210 nm. Meanwhile, the antibacterial tests demonstrated that the PCL ternary hybrid nanofibers containing Ti3C2TX and baicalin exhibited adequate antibacterial activity against the Gram-positive bacterial S. aureus due to the good synergistic effects of Ti3C2TX naoflakes and baicalin. The addition of Ti3C2TX nanoflakes and baicalin could significantly improve the hydrophilicity of the membranes, resulting in the release of baicalin from the nanofibers. In addition, the cytotoxicity of the nanofibers on rat skeletal myoblast L6 cells confirmed their good compatibility with these PCL-based nanofibrous membrances. This work offers a feasible way to prepare antibacterial nanofibrous membranes using Chinese herb extraction for wound dressing applications.

Development of SiC–TiO2-Graphene neem extracted antimicrobial nano membrane for enhancement of multiphysical properties and future prospect in dental implant applications

“…It is interesting to observe that with the increase of incorporation of neem extract, the fiber diameters are increased. These results are less or higher than the results of other literature and in almost all cases in nanofibrous membranes the fiber diameters are more than 100 nm [ 43 , 44 , 45 , 46 ] (see Figures 9 , 10 , 11 ).

Figure 7 SEM analysis of the developed nanomembrane sample with 0% neem at different resolutions (a) 50 μm, (b) 30 μm, (c) 20 μm, and (d) 10 μm.

…”

The enhanced properties and bioactivity of poly-ε-caprolactone/poly lactic-co-glycolic acid doped with carbonate hydroxyapatite–egg white

“…6a) due to the low conductivity of the PCL, which will produce a small net charge on the droplet surface. 34 Therefore, for meeting application requirements such as in bone grafts, PCL blended nanofibers were fabricated with increasing the flow rate to 30–35 μL m −1 .…”

Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration

“…As previously reported, the additives of small molecules that have multiple hydroxyl groups in the electrospinning of PCL affects the NF diameters by decreasing viscosity of solutions. 55,56 After the CHI-GA coating, the average diameters slightly increased to 563.1 ± 308.2 nm (Figure 2l). It also showed no significance (p > 0.5) in diameters of NFs between two groups, but the slight increase in the diameter was due to the formation of CHI-GA layers on CK/PCL NFs.…”