Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing

Augustine, Robin; Dominic, Edwin Anto; Reju, Indu; Kaimal, Balarama; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.1039/c4ra02450h

Cited by 180 publications

(108 citation statements)

References 45 publications

(43 reference statements)

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“…Concerning the polymer matrix, biocompatible and/or biodegradable polymers have been the preferred materials in order to prevent injuries or inflammation resulting from removal or rejection of electrospun scaffolds. In this regard, Augustine et al [9,21] designed fibrous materials based on polycaprolactone (PCL) and ZnO nanoparticles (ca. 60 nm in size), which exhibited excellent wound healing performance at low concentration (\2 wt%) and modest antimicrobial activity against Escherichia coli and Staphylococcus aureus only at relatively high concentration ([5 wt%).…”

Section: Introductionmentioning

confidence: 99%

Electrospinning and electrospraying techniques for designing novel antibacterial poly(3-hydroxybutyrate)/zinc oxide nanofibrous composites

Rodríguez-Tobías¹,

Morales²,

Ledezma³

et al. 2016

J Mater Sci

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This investigation concerns the design of poly(3-hydroxybutyrate) (PHB)-based nanofibrous hybrid materials containing zinc oxide nanoparticles (nano-ZnO) by means of two electro-hydrodynamic techniques, i.e., electrospinning of polymer/nano-ZnO solutions and the combination of electrospinning of polymer solutions with electrospraying of nano-ZnO dispersions. The analysis of the physical properties associated with precursory solutions was performed in order to understand the final morphology of the corresponding nanofibers. The obtained PHB/nano-ZnO mats showed uniform fiber morphology with an average porosity ca. 85 % with enhanced thermal stability compared to that of pristine PHB. Differential scanning calorimetry was also used to determine the influence of ZnO nanoparticles in the phase transitions of as-spun PHB nanofibers. Furthermore, the antibacterial performance against E. coli and S. aureus proved to be dependent on the elaboration technique, thus permitting the design of novel bacteriostatic or bactericidal PHB/nano-ZnO nanofibrous composites.

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Section: Introductionmentioning

confidence: 99%

Electrospinning and electrospraying techniques for designing novel antibacterial poly(3-hydroxybutyrate)/zinc oxide nanofibrous composites

Rodríguez-Tobías¹,

Morales²,

Ledezma³

et al. 2016

J Mater Sci

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“…[1][2][3][4][5]. Electrospinning of PCL has been reported by many workers for the past few decades [1,2,6,7].…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Effects of Gamma Irradiation on the Materials Properties and Cell Proliferation of Electrospun Polycaprolactone Tissue Engineering Scaffolds

Augustine

Saha

Jayachandran

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

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Electrospun membranes of polycaprolactone are widely used for biomedical applications like wound dressings and tissue engineering scaffolds. It is important to sterilize this material using the most accepted method, the gamma irradiation. In this study, we have evaluated the sterilizability of electrospun polycaprolactone membranes with gamma radiation of varying doses. The irradiated materials were assessed for the changes in morphology, crystallinity, surface degradation, hydrophilicity, mechanical property, sterility and the cell proliferation. Our results demonstrate that electrospun polycaprolactone can be effectively sterilized by gamma irradiation, however a higher dose of radiation affect the 2 materials properties. The irradiated membranes showed improved hydrophilicity and fibroblast cell proliferation.

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“…5a). Similar fi ndings were informed by Augustine in wound skin healing model 53) and by Sousa in wound bone healing 54) . Also, the presence of infl ammatory cells and new vascular formation surrounding ZnO particles (Table 1) an unresolved infl ammation could be related to the dissolution of ZnO and hence ROS generation.…”

Section: Discussionmentioning

confidence: 50%

Antibacterial Activity and Biocompability of Zinc Oxide and Graphite Particles as Endodontic Materials

Kozuszko

Sánchez

Ferro

et al. 2017

J. Hard Tissue Biology.

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Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing

Cited by 180 publications

References 45 publications

Electrospinning and electrospraying techniques for designing novel antibacterial poly(3-hydroxybutyrate)/zinc oxide nanofibrous composites

Electrospinning and electrospraying techniques for designing novel antibacterial poly(3-hydroxybutyrate)/zinc oxide nanofibrous composites

Dose-Dependent Effects of Gamma Irradiation on the Materials Properties and Cell Proliferation of Electrospun Polycaprolactone Tissue Engineering Scaffolds

Antibacterial Activity and Biocompability of Zinc Oxide and Graphite Particles as Endodontic Materials

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