Electrospun Polycaprolactone/Chitosan Nanofibers Containing Cordia myxa Fruit Extract as Potential Biocompatible Antibacterial Wound Dressings

Abstract

The goal of the current work was to create an antibacterial agent by using polycaprolactone/chitosan (PCL/CH) nanofibers loaded with Cordia myxa fruit extract (CMFE) as an antimicrobial agent for wound dressing. Several characteristics, including morphological, physicomechanical, and mechanical characteristics, surface wettability, antibacterial activity, cell viability, and in vitro drug release, were investigated. The inclusion of CMFE in PCL/CH led to increased swelling capability and maximum weight loss. The SEM images of the PCL/CH/CMFE mat showed a uniform topology free of beads and an average fiber diameter of 195.378 nm. Excellent antimicrobial activity was shown towards Escherichia coli (31.34 ± 0.42 mm), Salmonella enterica (30.27 ± 0.57 mm), Staphylococcus aureus (21.31 ± 0.17 mm), Bacillus subtilis (27.53 ± 1.53 mm), and Pseudomonas aeruginosa (22.17 ± 0.12 mm) based on the inhibition zone assay. The sample containing 5 wt% CMFE had a lower water contact angle (47 ± 3.7°), high porosity, and high swelling compared to the neat mat. The release of the 5% CMFE-loaded mat was proven to be based on anomalous non-Fickian diffusion using the Korsmeyer–Peppas model. Compared to the pure PCL membrane, the PCL-CH/CMFE membrane exhibited suitable cytocompatibility on L929 cells. In conclusion, the fabricated antimicrobial nanofibrous films demonstrated high bioavailability, with suitable properties that can be used in wound dressings.

Catalytic, Theoretical, and Biological Investigations of Ternary Metal (II) Complexes Derived from L-Valine-Based Schiff Bases and Heterocyclic Bases

“…The C=N- (azomethine) stretching frequency of the ligand showed a strong absorbance peak at 1643 cm −1 ; a shift toward the higher wavelength region (1610–1635 cm −1 ) of the metal(II) complexes revealed that the azomethine nitrogen had coordinated with metal ions ( Table 2 ) [ 21 ]. The bands at (1570–1590 cm −1 ) and (1350–1380 cm −1 ) were attributed to the asymmetric and symmetric vibrational frequencies, respectively, of the carboxyl groups present in the amino acid [ 22 , 23 , 24 , 25 ]. The absence of a band in the 1700–1750 cm −1 region suggested that the COO − group of L-valine was coordinated with the central metal ion and that the difference in the frequency value between the asymmetric and symmetric stretching vibrations of the complexes lay between 180 and 216 cm −1 , for which the latter is practically larger than that of a free carboxylate ion [ 26 ].…”

Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base

“…The FT-IR spectrometric method was used to obtain the IR spectrum of the synthesized complexes in the 400–4000 cm –1 range in ethanol. − The peak annotations of the present complexes are summarized in Table . The O-H stretching band was not detected at 3350 cm –1 , which proposes that phenolic O–H is deprotonated because of complex generation.…”

“…The in vitro antibacterial assay of metal­(II) complexes was tested against Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumonia, and Acinetobacter baumannii pathogens. , The zone of inhibition was measured for prepared complexes by the disc diffusion method, and their observation revealed that the complexes had significant antibacterial activity, as described in Figure , and their inhibition diameters are depicted in Table .…”

Zn2+/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

“…[12] The need for efficient tissue engineering products is constantly increasing, mainly due to the threat of the development of bacterial resistance to a wide range of antibacterial drugs commonly used in wound treatment. [13] The pH of human skin is generally a negligible physiological parameter, although it has a significant influence on the wound healing process. Healthy skin is slightly acidic with a pH in the range of 4-6, [14] but when injury occurs, the pH shifts to alkaline (up to 8.5).…”

“…[ 12 ] The need for efficient tissue engineering products is constantly increasing, mainly due to the threat of the development of bacterial resistance to a wide range of antibacterial drugs commonly used in wound treatment. [ 13 ]…”