Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membranes Aimed for Wound Healing Applications

Miguel, Sónia P.; Ribeiro, Maximiano P.; Coutinho, Paula; Correia, Ilídio J.

doi:10.3390/polym9050183

Cited by 161 publications

(114 citation statements)

References 115 publications

(154 reference statements)

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“…It was reported that the hydrophilic scaffolds in the range of 40°–70° exhibited maximum fibroblast cell adhesion and proliferation. The contact angle of PU/olive/honey/propolis lies within these limits which might have favored the enhanced HDF adhesion and proliferation .…”

Section: Resultsmentioning

confidence: 99%

Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering

et al. 2018

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The treatment for the bone diseases or defects such as tumor ablation, bone cysts and osteolysis were still challenging in clinical applications. Recently, the bone tissue engineering has emerged as a potential option for the treatment of bone defects. In this study, the nanofibrous composite scaffold consisting of polyurethane, olive oil, honey and propolis were fabricated through electrospinning method. The morphology of the nanofibrous scaffold indicated that nanofibers diameters were reduced with the addition of olive oil, honey and propolis into the Polyurethane (PU). The contact angle measurements showed that the behavior of PU/olive oil was found to hydrophobic (114° ± 1.528) and the PU/olive oil/honey/propolis scaffold rendered hydrophilic behavior (60° ± 1.528). FTIR and TG analysis revealed the interactions of PU with olive oil, honey/propolis and increased thermal stability of the composites. Atomic Force Microscopy (AFM) analysis displayed reduced surface roughness of the fabricated nanocomposite (PU/olive oil—469 nm and PU/olive oil/honey/propolis—449 nm) than the pristine PU (576 nm). The incorporation of olive oil, honey, and propolis resulted in the enhancement of the tensile strength (PU/olive oil—12.91 MPa and PU/olive oil/honey/propolis—14.346 MPa) compared with the pristine PU (7.12 MPa) as revealed in the mechanical testing. The blood clotting time of PU/olive oil (Activated partial thromboplastin time (APTT)—175 ±4 s and Partial thromboplastin time (PT)—103.3 ±3.512) was enhanced than pristine PU suggesting its improved anticoagulant behavior. Further, the developed scaffold showed low hemolytic index percentage (PU/olive oil—1.41% and PU/olive oil/honey/propolis—0.95%) than the control (2.48%) indicating its safety with RBC. Cytotoxicity test of the electrospun scaffold with human dermal fibroblast (HDF) cells using 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H tetrazolium assay demonstrated the non‐toxic and enhanced cell viability rates of HDF cells in developed scaffold than the pristine PU. Hence, the PU/olive oil/honey/propolis nanocomposite possessing better mechanical, physio‐chemical and biological properties might serve as a plausible candidate for bone tissue engineering. POLYM. COMPOS., 2018. © 2018 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 99%

Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering

et al. 2018

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“…Nonetheless, the use of bioactive materials together with PCL for the preparation of the electrospun mats has received great attention for novel development of membranes with superb cell proliferation and wound dressing [31][32][33][34]. For example, Correia and co-workers [35] investigated the use of extracted aloe vera chitosan nanofibrous materials and the subsequent fabrication using electrospinning method in the application of skin recovery and wound healing. It was discovered that the electrospun membranes promote the rapid cell proliferation and migration.…”

Section: Electrospun Nanoparticlesmentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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“…It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and AV) aimed to improve the bacterial activity of the membrane and ultimately the healing process. Miguel et al [36] obtained the results that the produced asymmetric membranes displayed porosity, wettability, as well as mechanical properties similar to those presented by the native skin.…”

Section: Aloe Vera Gel Scaffolds With Natural (Curcumin and Eggshell mentioning

confidence: 76%

Nutraceutical Aloe Vera Gel Scaffolds for Supporting a Healthy Muscle Movement

Yagi

Hasegawa

Mikami³

et al. 2018

Journal of Gastroenterology and Hepatology Research

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The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated based on locomotive syndrome risk test. Furthermore, w-3polyunsaturated fatty acids (EPA and DHA) and L-Arginine with AVJ revealed a possible dietary efficacy for Parkinson's disease (PD) patients at stage 3. Prophylactic possible efficacies of AVJ as bio-functional scaffolds are fully expected for increasing collagen synthesis in knee and/or hip joint healing and for mitigation of risk factors of PD patients with diabetes.

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Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membranes Aimed for Wound Healing Applications

Cited by 161 publications

References 115 publications

Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering

Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Nutraceutical Aloe Vera Gel Scaffolds for Supporting a Healthy Muscle Movement

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