Electrospun poly(ε-caprolactone) matrices containing silver sulfadiazine complexed with β-cyclodextrin as a new pharmaceutical dosage form to wound healing: preliminary physicochemical and biological evaluation

Abstract

Cooperation between researchers in the areas of medical, pharmaceutical and materials science has facilitated the development of pharmaceutical dosage forms that elicit therapeutic effects and protective action with a single product. In addition to optimizing pharmacologic action, such dosage forms provide greater patient comfort and increase success and treatment compliance. In the present work, we prepared semipermeable bioactive electrospun fibers for use as wound dressings containing silver sulfadiazine complexed with β-cyclodextrin in a poly(Ɛ-caprolactone) nanofiber matrix aiming to reduce the direct contact between silver and skin and to modulate the drug release. Wound dressings were prepared by electrospinning, and were subjected to ATR-FT-IR and TG/DTG assays to evaluate drug stability. The hydrophilicity of the fibrous nanostructure in water and PBS buffer was studied by goniometry. Electrospun fibers permeability and swelling capacity were assessed, and a dissolution test was performed. In vitro biological tests were realized to investigate the biological compatibility and antimicrobial activity. We obtained flexible matrices that were each approximately 1.0 g in weight. The electrospun fibers were shown to be semipermeable, with water vapor transmission and swelling indexes compatible with the proposed objective. The hydrophilicity was moderate. Matrices containing pure drug modulated drug release adequately during 24 h but presented a high hemolytic index. Complexation promoted a decrease in the hemolytic index and in the drug release but did not negatively impact antimicrobial activity. The drug was released predominantly by diffusion. These results indicate that electrospun PCL matrices containing β-cyclodextrin/silver sulfadiazine inclusion complexes are a promising pharmaceutical dosage form for wound healing.

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

“…In this work, the bioactive electrospun fibers containing silver sulfadiazine complexed with β-CD in the PCL nanofibers matrix were synthesized to modulate the drug release as well as to reduce the direct contact between silver and skin. Although complexation promoted a decrease in hemolytic Moreover, wound dressing material based on β-CD and PCL was also obtained by Souza et al [76]. In this work, the bioactive electrospun fibers containing silver sulfadiazine complexed with β-CD in the PCL nanofibers matrix were synthesized to modulate the drug release as well as to reduce the direct contact between silver and skin.…”

“…Authors proved that inclusion complexation between α-TC and β-CD during the formation of PCL electrospun nanofibers improves its photostability (~6% higher than un-encapsulated form) and antioxidant activity. Moreover, wound dressing material based on β-CD and PCL was also obtained by Souza et al [76]. In this work, the bioactive electrospun fibers containing silver sulfadiazine complexed with β-CD in the PCL nanofibers matrix were synthesized to modulate the drug release as well as to reduce the direct contact between silver and skin.…”

“…Moreover, wound dressing material based on β-CD and PCL was also obtained by Souza et al [ 76 ]. In this work, the bioactive electrospun fibers containing silver sulfadiazine complexed with β-CD in the PCL nanofibers matrix were synthesized to modulate the drug release as well as to reduce the direct contact between silver and skin.…”

Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications

“…The release occurs slowly, and 50% release was observed after two weeks of incubation, suggesting that the presented concept can be intended as a promising local drug delivery system for breast cancer therapy. Souza et al recently reported PCL nanofibers impregnated with β-CyD-silver sulfadiazine ICs [110]. Silver sulfadiazine (SAg) pertains to a sulfanilamide class of chemicals and is known for its topical antimicrobial properties, and is commonly used for the treatment of infected burns [111].…”

Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment

“…The most common forms of drugs currently used are: solutions, suspensions, creams, emulsions and ointments [4]. The most popular active substances in the treatment of hard-to-heal wounds are iodopovidone, silver ions (e.g., in form silver sulfadiazine, sulfasalazine, silver nitrate), polyhexamethylene, biguanide, octenidine, phenoxyethanol and chlorhexidine, as well as antibiotics [4][5][6][7][8]. These substances are effective in the initial stages of healing, but the problem related to their use is the short duration of activity at the damaged tissue area.…”