Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

Salehi, Majid; Shahporzadeh, Keyvan; Ehterami, Arian; Yeganehfard, Hodays; Ziaei, Heliya; Azizi, Mohammad Moein; Farzamfar, Saeed; Tahersoltani, Amirreza; Goodarzi, Arash; Ai, Jafar; Ahmadi, Aslan

doi:10.1007/s12221-020-9825-8

Cited by 15 publications

(10 citation statements)

References 39 publications

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“…In the current study, the tensile strength values of fiber mats declined when the PE content loaded into the PCL/GEL electrospun nanofibers increased. Our results also agree with previous studies demonstrating that loading plant extracts in elec-trospun nanofibers reduces the mechanical performance of nanofibrous materials [37][38][39]. Several explications have been attributed to the reduction in the mechanical properties of fibrous materials after loading natural compounds.…”

Section: Discussionsupporting

confidence: 92%

“…The wettability of electrospun nanofiber mats is an essential property for biomedical applications since they should absorb wound exudates and maintain moisturized environments for wound healing [5,15,38]. When the hydrophilicity was measured, it was found that the contact angle for the PCL/GEL/0.18%PE electrospun nanofiber significantly decreased compared to the PCL/GEL sample.…”

Section: Discussionmentioning

confidence: 99%

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Fabrication of Biocompatible Electrospun Poly(ε-caprolactone)/Gelatin Nanofibers Loaded with Pinus radiata Bark Extracts for Wound Healing Applications

et al. 2022

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In this study, poly(ε-caprolactone) (PCL)/gelatin (GEL) electrospun nanofibers loaded with two different concentrations of Pinus radiata bark extracts (PEs) were fabricated via electrospinning for wound healing applications. The effects of incorporating PE into PCL/GEL electrospun nanofibers were investigated regarding their physicochemical properties and in vitro biocompatibility. All electrospun nanofibers showed smooth, uniform, and bead-free surfaces. Their functional groups were detected by ATR-FTIR spectroscopy, and their total phenol content was measured by a Folin–Ciocalteu assay. With PE addition, the electrospun nanofibers exhibited an increase in their wettability and degradation rates over time and a decrease in their tensile stress values from 20 ± 4 to 8 ± 2 MPa for PCL/GEL and PCL/GEL/0.36%PE samples, respectively. PE was also released from the fibrous mats in a rather controlled fashion. The PCL/GEL/0.18%PE and PCL/GEL/0.36%PE electrospun nanofibers inhibited bacterial activity at around 6 ± 0.1% and 23 ± 0.3% against E. coli and 14 ± 0.1% and 18 ± 0.2% against S. aureus after 24 h incubation, respectively. In vitro cell studies showed that PE-loaded electrospun nanofibers enhanced HaCaT cell growth, attachment, and proliferation, favoring cell migration towards the scratch area in the wound healing assay and allowing a complete wound closure after 72 h treatment. These findings suggested that PE-loaded electrospun nanofibers are promising materials for antibiotic-free dressings for wound healing applications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Fabrication of Biocompatible Electrospun Poly(ε-caprolactone)/Gelatin Nanofibers Loaded with Pinus radiata Bark Extracts for Wound Healing Applications

et al. 2022

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“…6,8 PCL is a semi-crystalline synthetic polymer used in biomedical applications because of its low melting point, high tensile strength, ease of processability, mechanical strength, adequate stability under ambient temperatures, non-toxic nature and biodegradability. 6,8,[10][11][12] PCL lacks an active surface suitable for cell functions, and its weak hydrophilicity reduces its cytocompatibility. 7,9 Therefore, scientists have considered combining PCL with natural hydrophilic polymers with chemically reactive surfaces, such as chitosan, alginate and Gel, to counteract this drawback.…”

Section: Introductionmentioning

confidence: 99%

“…7,9 Therefore, scientists have considered combining PCL with natural hydrophilic polymers with chemically reactive surfaces, such as chitosan, alginate and Gel, to counteract this drawback. [8][9][10] Gel is an easily obtainable biopolymer derived from collagen, the most prevalent structural protein found in animal connective tissues such as skin, tendon, cartilage and bone. 5 In addition, its low cost, biocompatibility and non-immunogenicity make it favorable in the biomedical industry.…”

Section: Introductionmentioning

confidence: 99%

“…7 Previous studies showed that PCL contributes to the mechanical strength of the structure, whereas Gel contributes to its cell adhesion, proliferation and biodegradability. 10,11 Inorganic nanoparticles (NPs) have a crucial role in the creation of potent antibacterial agents. 14 Gold nanoparticle (AuNP), which is one of the inorganic NPs, have a high specific surface area, ease of functional group modification, diverse optical properties, photothermal properties and broad-spectrum antibacterial action.…”

Section: Introductionmentioning

confidence: 99%

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Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing

Rezaei Kolarijani,

Cheraghali,

Khastar

et al. 2023

Wound Repair Regeneration

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In the current study, Gold Nanoparticles were loaded into poly (ε‐caprolactone)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of poly (ε‐caprolactone)/Gelatin solution supplemented with synthesized Gold Nanoparticles (200 ppm, 400 ppm, and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface wettability, water‐uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test, and cellular response. In addition to in vivo study, a full‐thickness excisional wound in a rat model was used to evaluate the healing effect of prepared scaffolds. Results showed appropriate mechanical properties and porosity of prepared scaffolds. With L929 cells, the PCL/Gelatin scaffold containing 400 ppm gold nanoparticles demonstrated the greatest cell growth. In vivo results validated the favorable wound‐healing benefits of the scaffold incorporating gold nanoparticles, which triggered wound healing compared to sterile gauze. Our results showed the capability of nanofibrous matrices containing gold nanoparticles for successful wound treatment.This article is protected by copyright. All rights reserved.

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Evaluation of a Polycaprolactone/Gelatin/Lucilia sericata Larva Extract Nanofibrous Mat for Burn-Wound Healing

Hashemi,

Hayatdavoodi,

Kian

et al. 2023

Fibers Polym

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Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

Cited by 15 publications

References 39 publications

Fabrication of Biocompatible Electrospun Poly(ε-caprolactone)/Gelatin Nanofibers Loaded with Pinus radiata Bark Extracts for Wound Healing Applications

Fabrication of Biocompatible Electrospun Poly(ε-caprolactone)/Gelatin Nanofibers Loaded with Pinus radiata Bark Extracts for Wound Healing Applications

Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing

Evaluation of a Polycaprolactone/Gelatin/Lucilia sericata Larva Extract Nanofibrous Mat for Burn-Wound Healing

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