Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing

Abstract

In the current study, Gold Nanoparticles were loaded into poly (ε‐caprolactone)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of poly (ε‐caprolactone)/Gelatin solution supplemented with synthesized Gold Nanoparticles (200 ppm, 400 ppm, and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface wettability, water‐uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test, and cellular response. In addition to in vivo study, a full‐thickness excisional wound in a rat model was used to evaluate the healing effect of prepared scaffolds. Results showed appropriate mechanical properties and porosity of prepared scaffolds. With L929 cells, the PCL/Gelatin scaffold containing 400 ppm gold nanoparticles demonstrated the greatest cell growth. In vivo results validated the favorable wound‐healing benefits of the scaffold incorporating gold nanoparticles, which triggered wound healing compared to sterile gauze. Our results showed the capability of nanofibrous matrices containing gold nanoparticles for successful wound treatment.This article is protected by copyright. All rights reserved.

Nanofiber-based wound dressing in wound healing of elderly patients

“…study validate the advantageous wound healing properties of scaffolds incorporating gold nanoparticles, which outperform sterile gas in promoting wound healing. Additionally, the study showcases the efficacy of nanofiber matrices containing gold nanoparticles in effectively treating wounds [ 15 ]. Cytotoxicity and antibacterial test results of the study by Cui et al .…”

Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Oral Applications

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