Electrospun PLGA Membrane Incorporated With andrographolide-loaded Mesoporous Silica Nanoparticles for Sustained Antibacterial Wound Dressing

Jia, Yuhang; Yang, Shengbing; Xi, Zhenhao; Tang, Tingting; Yin, Ruixue; Zhang, Wenjun

doi:10.2217/nnm-2018-0099

Cited by 52 publications

(28 citation statements)

References 48 publications

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“…Physicochemical properties of the Ag-Si/Al 2 O 3 sorbents presented on Table 2 were calculated by Rachkovskaya et al [41]. It can be seen that the proportion of loaded content of Ag present in the sorbent quantified by optical emission spectroscopy (ICP-OES) from this study, where sample content is 0.01% Ag with the exception of sorbent Ag-Si/Al 2 O 3 -2 (0.003% Ag), the content of Ag in samples is related to its antimicrobial activity [14][15][16]. In the case of the particle sizes was assessed by screen size gradation (0.1-1 mm) [41], being an important parameter for water absorption, due to a reported relationship between the increment of particle size decreases mechanical parameters and increases water absorption [60], the sorbents from this work possess high particle size expecting adequate ability for water uptake.…”

Section: Water Uptake Testmentioning

confidence: 68%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

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Section: Water Uptake Testmentioning

confidence: 68%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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“…Apart from BC and PC, other products such as hydrogels, poly lactic-co-glycolic acid (PLGA), and 3D living constructs are being studied for their effectiveness in wound healing [ 99 , 100 , 101 , 102 ]. In current era, 3D bioprinting gaining much attention as other available biomaterial due to its ability to design cell components in microarchitecture.…”

Section: Alternative Biomaterials For Wound Healingmentioning

confidence: 99%

“…A study done by Jia et al demonstrated that the integration of andrographolide-MSN enhanced hydrophilicity, increased mechanical strength, optimum porosity and pH, possessed strong antibacterial properties and enhanced epidermal cell adhesion and growth. This modification thereby stimulates the rapid wound healing in the in vivo testing [ 100 ].…”

Section: Alternative Biomaterials For Wound Healingmentioning

confidence: 99%

Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review

Naomi

Idrus

Fauzi

2020

IJERPH

105

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Cellulose is a naturally existing element in the plant’s cell wall and in several bacteria. The unique characteristics of bacterial cellulose (BC), such as non-toxicity, biodegradability, hydrophilicity, and biocompatibility, together with the modifiable form of nanocellulose, or the integration with nanoparticles, such as nanosilver (AgNP), all for antibacterial effects, contributes to the extensive usage of BC in wound healing applications. Due to this, BC has gained much demand and attention for therapeutical usage over time, especially in the pharmaceutical industry when compared to plant cellulose (PC). This paper reviews the progress of related research based on in vitro, in vivo, and clinical trials, including the overall information concerning BC and PC production and its mechanisms in wound healing. The physicochemical differences between BC and PC have been clearly summarized in a comparison table. Meanwhile, the latest Food and Drug Administration (FDA) approved BC products in the biomedical field are thoroughly discussed with their applications. The paper concludes on the need for further investigations of BC in the future, in an attempt to make BC an essential wound dressing that has the ability to be marketable in the global marketplace.

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“…Like lipid-based NPs, polymeric NPs might also affect drugs' pharmacokinetics in wound environments, thus enabling us to explore potential off-label uses of current drugs. Jia et al (2018) developed nanofibrous PLGA incorporating andrographolideloaded mesoporous silica NPs. Their results showed that the sustained releasing of andrographolide, which is extracted from a Chinese herb, surprisingly reduced inflammation intensity while promoting epidermal cells adhesion.…”

Section: Polymeric Npsmentioning

confidence: 99%

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

Wang

Armato

2020

Front. Bioeng. Biotechnol.

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Chronic wounds caused by infections, diabetes, and radiation exposures are becoming a worldwide growing medical burden. Recent progress highlighted the physical signals determining stem cell fates and bacterial resistance, which holds potential to achieve a better wound regeneration in situ. Nanoparticles (NPs) would benefit chronic wound healing. However, the cytotoxicity of the silver NPs (AgNPs) has aroused many concerns. This review targets the tunable physical properties (i.e., mechanical-, structural-, and size-related properties) of either dermal matrixes or wound dressings for chronic wound care. Firstly, we discuss the recent discoveries about the mechanical-and structural-related regulation of stem cells. Specially, we point out the currently undocumented influence of tunable mechanical and structural properties on either the fate of each cell type or the whole wound healing process. Secondly, we highlight novel dermal matrixes based on either natural tropoelastin or synthetic elastin-like recombinamers (ELRs) for providing elastic recoil and resilience to the wounded dermis. Thirdly, we discuss the application of wound dressings in terms of size-related properties (i.e., metal NPs, lipid NPs, polymeric NPs). Moreover, we highlight the cytotoxicity of AgNPs and propose the size-, dose-, and time-dependent solutions for reducing their cytotoxicity in wound care. This review will hopefully inspire the advanced design strategies of either dermal matrixes or wound dressings and their potential therapeutic benefits for chronic wounds.

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Electrospun PLGA Membrane Incorporated With andrographolide-loaded Mesoporous Silica Nanoparticles for Sustained Antibacterial Wound Dressing

Cited by 52 publications

References 48 publications

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

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