Electrospun nanofibrous alginate sulfate scaffolds promote mesenchymal stem cells differentiation to chondrocytes

Irani, Shiva; Tavakkoli, Sajjad; Pezeshki‐Modaress, Mohamad; Taghavifar, Elham; Mohammadali, Marjan; Daemi, Hamed

doi:10.1002/app.49868

Cited by 18 publications

(6 citation statements)

References 47 publications

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“…The results demonstrated that human bone marrow (hBM) MSCs attach appropriately and spread on the resulting nanofibrous mats. In addition, the results of type-II collagen expression and immunocytochemistry analyses revealed the chondrogenic differentiation of hBM‐MSCs on alginate sulfate nanofibrous mats [ 114 ].…”

Section: Reviewmentioning

confidence: 99%

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Nabizadeh¹,

Nasrollahzadeh²,

Daemi³

et al. 2022

Beilstein J. Nanotechnol.

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Osteoarthritis, which typically arises from aging, traumatic injury, or obesity, is the most common form of arthritis, which usually leads to malfunction of the joints and requires medical interventions due to the poor self-healing capacity of articular cartilage. However, currently used medical treatment modalities have reported, at least in part, disappointing and frustrating results for patients with osteoarthritis. Recent progress in the design and fabrication of tissue-engineered microscale/nanoscale platforms, which arises from the convergence of stem cell research and nanotechnology methods, has shown promising results in the administration of new and efficient options for treating osteochondral lesions. This paper presents an overview of the recent advances in osteochondral tissue engineering resulting from the application of micro- and nanotechnology approaches in the structure of biomaterials, including biological and microscale/nanoscale topographical cues, microspheres, nanoparticles, nanofibers, and nanotubes.

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Section: Reviewmentioning

confidence: 99%

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Nabizadeh¹,

Nasrollahzadeh²,

Daemi³

et al. 2022

Beilstein J. Nanotechnol.

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“…Alginate sulfate was selected as an efficient substitute for bioactive glycosaminoglycans (GAGs) to be used as a functional support system. The produced nanofibers showed appropriate cytocompatibility and promoted bone marrow mesenchymal stem cells’ growth and differentiation into chondrocytes, demonstrating the great potential of alginate sulfate nanofibers for cartilage tissue engineering applications [ 84 ]. Due to the anti-adhesive properties of alginates, novel anti-adhesion barriers based on alginate electrospun nanofibers have been reported to prevent postoperative peritoneal adhesion [ 85 , 86 ].…”

Section: Seaweed-derived Biopolymersmentioning

confidence: 99%

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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Marine biopolymers, abundantly present in seaweeds and marine animals, feature diverse structures and functionalities, and possess a wide range of beneficial biological activities. Characterized by high biocompatibility and biodegradability, as well as unique physicochemical properties, marine biopolymers are attracting a constantly increasing interest for the development of advanced systems for applications in the biomedical field. The development of electrospinning offers an innovative technological platform for the production of nonwoven nanofibrous scaffolds with increased surface area, high encapsulation efficacy, intrinsic interconnectivity, and structural analogy to the natural extracellular matrix. Marine biopolymer-based electrospun nanofibrous scaffolds with multifunctional characteristics and tunable mechanical properties now attract significant attention for biomedical applications, such as tissue engineering, drug delivery, and wound healing. The present review, covering the literature up to the end of 2021, highlights the advancements in the development of marine biopolymer-based electrospun nanofibers for their utilization as cell proliferation scaffolds, bioadhesives, release modifiers, and wound dressings.

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“…[ 6 ] By exploiting the benefits of emulsion electrospinning, such as providing a simple, affordable, and cost‐effective approach, extensive work has been done to employ this process in the manufacture of core‐shell micro/nanofibrous systems for a wide number of applications, especially sustained or controlled drug delivery. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…SSA has many applications in drug delivery systems and skin tissue engineering because of its biocompatibility, biodegradability, anti‐inflammatory accessibility, and cost‐effective properties. [ 7 ] Due to the negative charge of SSA, it can be useful to entrap the Cu 2+ ion with a positive charge and lead to a sustained release. PVA, as a carrier polymer in the shell part, was expected to reduce the repulsive force between the SSA chains and improve the chain flexibility.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Diabetic Wound Healing Through Improved Angiogenesis: The Role of Emulsion‐Based Core‐Shell Micro/Nanofibrous Scaffold with Sustained CuO Nanoparticle Delivery

Alizadeh,

Samadikuchaksaraei,

Jafari

et al. 2024

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Attempts are made to design a system for sustaining the delivery of copper ions into diabetic wounds and induce angiogenesis with minimal dose‐dependent cytotoxicity. Here, a dual drug‐delivery micro/nanofibrous core‐shell system is engineered using polycaprolactone/sodium sulfated alginate‐polyvinyl alcohol (PCL/SSA‐PVA), as core/shell parts, by emulsion electrospinning technique to optimize sustained delivery of copper oxide nanoparticles (CuO NP). Herein, different concentrations of CuO NP (0.2, 0.4, 0.8, and 1.6%w/w) are loaded into the core part of the core‐shell system. The morphological, biomechanical, and biocompatibility properties of the scaffolds are fully determined in vitro and in vivo. The 0.8%w/w CuO NP scaffold reveals the highest level of tube formation in HUVEC cells and also upregulates the pro‐angiogenesis genes (VEGFA and bFGF) expression with no cytotoxicity effects. The presence of SSA and its interaction with CuO NP, and also core‐shell structure sustain the release of the nanoparticles and provide a non‐toxic microenvironment for cell adhesion and tube formation, with no sign of adverse immune response in vivo. The optimized scaffold significantly accelerates diabetic wound healing in a rat model. This study strongly suggests the 0.8%w/w CuO NP‐loaded PCL/SSA‐PVA as an excellent diabetic wound dressing with significantly improved angiogenesis and wound healing.

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Electrospun nanofibrous alginate sulfate scaffolds promote mesenchymal stem cells differentiation to chondrocytes

Cited by 18 publications

References 47 publications

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

Enhancing Diabetic Wound Healing Through Improved Angiogenesis: The Role of Emulsion‐Based Core‐Shell Micro/Nanofibrous Scaffold with Sustained CuO Nanoparticle Delivery

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