Electrospun Nanofibers Made of Silver Nanoparticles, Cellulose Nanocrystals, and Polyacrylonitrile as Substrates for Surface-Enhanced Raman Scattering

Ren, Suxia; Dong, Lili; Zhang, Xiuqiang; Lei, Tingzhou; Ehrenhauser, Franz S.; Song, Kunlin; Li, Mei‐Chun; Sun, Xiuxuan; Wu, Qinglin

doi:10.3390/ma10010068

Cited by 36 publications

(18 citation statements)

References 41 publications

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“…Although there was no significant difference in the fiber diameters, a minimum in the average fiber diameter can be seen at a silver concentration of 3%. This could be due to the increase in the electrical conductivity due to the presence of silver . This leads to increase in the surface charge of the polymer solution which thus experiences stronger elongation forces, resulting in thinner fibers.…”

Section: Resultsmentioning

confidence: 99%

Silver Loaded Nanofibrous Curdlan Mat for Diabetic Wound Healing: An In Vitro and In Vivo Study

Basha

Kumar

Selvaraj

et al. 2018

Macro Materials & Eng

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A fibrous scaffold of curdlan/poly(vinyl alcohol) (PVA) blend is prepared by electrospinning technique and antimicrobial property is imparted to it by the addition of silver nitrate (1, 3, and 5 wt%). All the scaffolds except the PVA/curdlan with 5 wt% AgNO3 show good viability of Swiss 3T3 fibroblast cells. Significant reductions in the growth of Staphylococcus aureus and Escherichia coli are also observed in all the scaffolds. In vitro scratch assay and cell adhesion studies indicate that the scaffold containing 1% AgNO3 shows significant wound healing and better cell spreading. The in vivo results also show faster healing of excision wounds in diabetic rats treated with the same material when compared to the control and the commercial sample. Furthermore, downregulation of proinflammatory cytokines and upregulation of anti‐inflammatory cytokines on the skin of the treated animals confirm that PVA/curdlan/1% AgNO3 electrospun mat could be a promising material for diabetic wound healing.

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Section: Resultsmentioning

confidence: 99%

Silver Loaded Nanofibrous Curdlan Mat for Diabetic Wound Healing: An In Vitro and In Vivo Study

Basha

Kumar

Selvaraj

et al. 2018

Macro Materials & Eng

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“…It was interesting to observe that the spectra of pure PAN nanofibers were not affected by impregnation of AgSD in PAN nanofibers, which indicates that there may be no chemical reaction between PAN and AgSD. 29,30 PAN showed prominent peaks at 1,452 cm -1 , 1,664 cm -1 , 2,240 cm -1 , and 2,923 cm -1 . Peaks at 1,664 cm -1 , 2,240 cm -1 , and 2,923 cm -1 represent stretching vibrations of -C=N, -C≡N, and -CH groups, respectively, while the peak at 1,452 cm -1 represents bending vibration of -CH2 group.…”

Section: Ftir Interpretationmentioning

confidence: 94%

“…Surface-modified PAN nanofibers have been also used as a substrate for identification of small molecules by surface-enhanced Raman scattering. 30 Electrospinning is a useful technique to fabricate nanofibers having diameters ranging from tens of nanometer to microns. 31,32 Electrospinning was introduced in 1931 and hence is not a new method for fabrication of nanofibers, but a proper setup for producing nanofibers by this method became practical and popular in the early 21st century.…”

Section: Introductionmentioning

confidence: 99%

<p>Antibacterial properties of in situ and surface functionalized impregnation of silver sulfadiazine in polyacrylonitrile nanofiber mats</p>

Ullah¹,

Hashmi²,

Kharaghani³

et al. 2019

IJN

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Background: Silver, incorporation with natural or synthetic polymers, has been used as an effective antibacterial agent since decades. Silver has potential applications in healthcare especially in nanoparticles form but silver sulfadiazine (AgSD) is the most efficient antibacterial agent especially for burn wound dressings. Method: In this report, mechanical, structural, and antibacterial properties of PAN nanofibers incorporation with silver sulfadiazine are mainly focused. AgSD was loaded for the first time on electrospinning as well as self-synthesized AgSD on PAN nanofibers by solution immersion method and then compared the results of both. Results: Occurrence of chemical reaction among the functional groups of AgSD and PAN were analyzed using FTIR, for both types of specimen. Morphological and surface properties of prepared nanofiber mats were characterized by scanning electron microscope, and it resulted in uniform nanofibers without bead formation. Diameter of nanofibers was slightly increased with addition of AgSD by in situ and immersion methods respectively. Nanoparticles distribution was analyzed by transmission electron microscopy. Thermal properties were analyzed by thermogravimetric analyzer and it was observed that AgSD decreased thermal stability of PAN which is better from biomedical perspective. X-ray diffraction declared crystalline structure of nanofiber mats. Presence of Ag and S contents in nanofiber mats was analyzed by X-ray photo spectroscopy. Antibacterial properties of nanofiber mats were investigated by disc diffusion method was carried out. E. coli and Bacillus bacteria strain were used as gram-negative and gram-positive respectively. Zone inhibition of the bacteria was used as a tool to determine effectiveness of AgSD released from PAN nanofiber mats. The antibacterial properties of PAN nanofibers impregnated with AgSD were determined with both types of bacteria strains to compare with control one. Conclusion: On the basis of characterization results it is concluded that PAN/AgSD (immersion) nanofiber mats have better structural and antibacterial properties than that of PAN/AgSD (in situ) nanofiber mats. So, from our point of view, self-synthesized AgSD is recommended for further production of nanofiber mats for antibacterial applications.

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“…Electrospun nanofibers containing nanoparticles is another area of research that has been widely investigated for various applications, including surface-enhanced Raman scattering [156], antimicrobial packaging [157], dye-sensitized solar cells [158], food preservation [159], biowarfare decontamination [160], water treatment [161], high-performance gas sensing [162], and environmental remediation [163]. In drug delivery, these novel impregnated nanofibers are being explored in the areas of wound care, regenerative medicine, dental engineering, and for cancer treatment.…”

Section: Electrospun Nanofibers In Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery

et al. 2018

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The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties can also be modified by polarity inversion and by varying the collector design. The active moiety is incorporated into polymeric fibers by blending, surface modification or emulsion formation. The nanofibers can be further modified to deliver multiple drugs, and multilayer polymer coating allows sustained release of the incorporated active moiety. Electrospun nanofibers prepared from polymers are used to deliver antibiotic and anticancer agents, DNA, RNA, proteins and growth factors. This review provides a compilation of studies involving the use of electrospun fibers in biomedical applications with emphasis on nanoparticle-impregnated nanofibers.

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Electrospun Nanofibers Made of Silver Nanoparticles, Cellulose Nanocrystals, and Polyacrylonitrile as Substrates for Surface-Enhanced Raman Scattering

Cited by 36 publications

References 41 publications

Silver Loaded Nanofibrous Curdlan Mat for Diabetic Wound Healing: An In Vitro and In Vivo Study

Silver Loaded Nanofibrous Curdlan Mat for Diabetic Wound Healing: An In Vitro and In Vivo Study

<p>Antibacterial properties of in situ and surface functionalized impregnation of silver sulfadiazine in polyacrylonitrile nanofiber mats</p>

Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery

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