Electrospun nanofibers in wound healing

Sylvester, Melisa Anne; Amini, Farahnaz; Tan, Chung Keat

doi:10.1016/j.matpr.2020.05.686

Cited by 28 publications

(17 citation statements)

References 48 publications

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“…The efficacy of silver nanoparticles and the active healing properties of chitosan polymer hydrogels received numerous publications. With the development of electrospinning processes, the research focus increasingly shifted to electrospun nanofibers, which exhibit antimicrobial properties through the addition of nanoparticles [154,155]. Due to their high mechanical strength and good biocompatibility, carbon-based nanofibers offer further areas of application in biomedicine [156][157][158].…”

Section: Biotechnological and Medical Fieldsmentioning

confidence: 99%

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

et al. 2021

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In recent years, ecological issues have led to the search for new green materials from biomass as precursors for producing carbon materials (CNFs). Such green materials are more attractive than traditional petroleum-based materials, which are environmentally harmful and non-biodegradable. Biomass could be ideal precursors for nanofibers since they stem from renewable sources and are low-cost. Recently, many authors have focused intensively on nanofibers’ production from biomass using microwave-assisted pyrolysis, hydrothermal treatment, ultrasonication method, but only a few on electrospinning methods. Moreover, still few studies deal with the production of electrospun carbon nanofibers from biomass. This review focuses on the new developments and trends of electrospun carbon nanofibers from biomass and aims to fill this research gap. The review is focusing on recollecting the most recent investigations about the preparation of carbon nanofiber from biomass and biopolymers as precursors using electrospinning as the manufacturing method, and the most important applications, such as energy storage that include fuel cells, electrochemical batteries and supercapacitors, as well as wastewater treatment, CO2 capture, and medicine.

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Section: Biotechnological and Medical Fieldsmentioning

confidence: 99%

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

et al. 2021

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“…Their 3D structure mimics the ECM architecture of the skin, which has an important role to play in the maintenance of cell adhesion, long‐term survival, and proliferation processes 100 . Nanoporosity facilitates cell respiration and gas permeation while preventing the penetration of microbial particles and tissue inflammation 101,102 . The porous texture and nanoporosity of these nanofibrous matrices are compatible with bacterial contamination prevention, nutrient, and gaseous exchanges, and adsorption of injury exudates, so the scaffold's architecture can aid attachment, migration, cell infiltration, and proliferation 102‐104 .…”

Section: Need For Biomaterials Scaffolding Approach and Nanofibers For Skin Tissue Engineeringmentioning

confidence: 99%

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Behere

Ingavle

2021

J Biomedical Materials Res

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The skin is one of the most essential tissues in the human body, interacting with the outside environment and shielding the body from diseases and excessive water loss. Hydrogels, decellularized porcine dermal matrix, and lyophilized polymer scaffolds have all been used in studies of skin wound repair, wound dressing, and skin tissue engineering, however, these materials cannot replicate the nanofibrous architecture of the skin's native extracellular matrix (ECM). Electrospun nanofibers are a fascinating new form of nanomaterials with tremendous potential across a broad spectrum of applications in the biomedical field, including wound dressings, wound healing scaffolds, regenerative medicine, bioengineering of skin tissue, and multifaceted drug delivery. This article reviews recent in vitro and in vivo developments in multifunctional electrospun nanofibers (MENs) for wound healing. This review begins with an introduction to the electrospinning process, its principle, and the processing parameters which have a significant impact on the nanofiber properties. It then discusses the various geometries and advantages of MEN scaffolds produced by different innovative electrospinning techniques for wound healing applications when used in combination with stem cells. This review also discusses some of the possible future nanofiber‐based models that could be used. Finally, we conclude with potential perspectives and conclusions in this area.

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“…Nowadays, nanofibers are used for skin regeneration and rejuvenation as scaffolds, and for drug delivery. They can be composed of natural, synthetic and mixed polymers, each showing peculiar characteristics [101]. Natural polymers are highly biocompatible, non-toxic, biodegradable, often possess antibiotic activity per se, and can elicit skin contraction during the process of wound healing, ameliorating wound treatment, [102,103].…”

Section: Nanofibers and Scaffoldsmentioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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Electrospun nanofibers in wound healing

Cited by 28 publications

References 48 publications

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Nanomaterials in Skin Regeneration and Rejuvenation

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