Electrospun nanofibers for the fabrication of engineered vascular grafts

Karkan, Sonia Fathi; Davaran, Soodabeh; Rahbarghazi‬, Reza; Salehi, Roya; Akbarzadeh, Abolfazl

doi:10.1186/s13036-019-0199-7

Cited by 39 publications

(28 citation statements)

References 124 publications

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“…Considering these limitations, extensive experiments and studies in the field of TEBV have been done [ 17 ]. Synthetic materials such as PTFE, PET (Dacron), PVC, PA (Nylon), PP, PTFE, PET-based grafts, and polyesters, including poly(−caprolactone) (PCL), polylactic acid (PLA), and polyglycolic acid, have been successful in large-caliber vessels substitute such as in aortoiliac replacement and medium-caliber arteries around 6–8 mm [ 18 , 19 ].…”

Section: Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

“…Among the existing approaches to fabricate artificial ECM, nanofibers have shown the most promising results [ 27 ]. One of the most promising methods for manufacturing nanofibrous vascular grafts is electrospinning, making us able to fabricate aligned or random nanofibers with a high surface-to-mass ratio [ 17 ]. These scaffolds are applicable in tissue engineering, wound healing, sensor development, and controlled release of therapeutic agents [ 28 ].…”

Section: Nanofibers In Tissue Engineeringmentioning

confidence: 99%

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A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds

Karkan

Banimohamad-Shotorbani

Saghati

et al. 2022

J Biol Eng

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Certain polymeric materials such as polyurethanes (PUs) are the most prevalent class of used biomaterials in regenerative medicine and have been widely explored as vascular substitutes in several animal models. It is thought that PU-based biomaterials possess suitable hemo-compatibility with comparable performance related to the normal blood vessels. Despite these advantages, the possibility of thrombus formation and restenosis limits their application as artificial functional vessels. In this regard, various surface modification approaches have been developed to enhance both hemo-compatibility and prolong patency. While critically reviewing the recent advances in vascular tissue engineering, mainly PU grafts, this paper summarizes the application of preferred cell sources to vascular regeneration, physicochemical properties, and some possible degradation mechanisms of PU to provide a more extensive perspective for future research.

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Section: Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

Section: Nanofibers In Tissue Engineeringmentioning

confidence: 99%

A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds

Karkan

Banimohamad-Shotorbani

Saghati

et al. 2022

J Biol Eng

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“…It contains three elements: seed cells, scaffold materials and signals [ 9 ]. In general, scaffolds are used as supporting structures to make seed cells adhere and proliferate, reaching functional maturity [ 10 ]. However, different scaffold materials have variant properties, the common scaffold materials of TEVGs ( Fig.…”

Section: Common Types and Materials Of Tevgsmentioning

confidence: 99%

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Cai

Liao

Xue

et al. 2021

Bioactive Materials

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Tissue-engineered vascular grafts (TEVGs) have enormous potential for vascular replacement therapy. However, thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs (<6 mm) after transplantation. Endothelialization of TEVGs is a key point to prevent thrombosis. Here, we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts. Meanwhile, endothelial heterogeneity is also discussed. Based on it, we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.

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“…Electrospinning of natural materials and synthetic polymers into nanofibers is a typical application of nanotechnology for tissue engineering [13][14][15][16]. This approach has numerous advantages, including high porosity, high surface-area-to-volume ratio, and ease of incorporation of cell signaling molecules, thus mimicking the dimensions and structures of native collagen and elastin [17][18][19]. He W et al used electrospinning to fabricate a fibrous scaffold made of poly(L-lactic acid)-co-poly(ecaprolactone) composite, and the results showed enhanced endothelial attachment and spreading in vitro [20].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model

Lee

Kayumov

Emechebe

et al. 2022

Tissue Eng Regen Med

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Background: We have designed a reinforced drug-loaded vascular graft composed of polycaprolactone (PCL) and polydioxanone (PDO) via a combination of electrospinning/3D printing approaches. To evaluate its potential for clinical application, we compared the in vivo blood compatibility and performance of PCL/PDO + 10%DY grafts doped with an antithrombotic drug (dipyridamole) with a commercial expanded polytetrafluoroethylene (e-PTFE) graft in a porcine model. Methods: A total of 10 pigs (weight: 25–35 kg) were used in this study. We made a new 5-mm graft with PCL/PDO composite nanofiber via the electrospinning technique. We simultaneously implanted a commercially available e-PTFE graft (n = 5) and our PCL/PDO + 10%DY graft (n = 5) into the carotid arteries of the pigs. No anticoagulant/antiplatelet agent was administered during the follow-up period, and ultrasonography was performed weekly to confirm the patency of the two grafts in vivo. Four weeks later, we explanted and compared the performance of the two grafts by histological analysis and scanning electron microscopy (SEM). Results: No complications, such as sweating on the graft or significant bleeding from the needle hole site, were seen in the PCL/PDO + 10%DY graft immediately after implantation. Serial ultrasonographic examination and immunohistochemical analysis demonstrated that PCL/PDO + 10%DY grafts showed normal physiological blood flow and minimal lumen reduction, and pulsed synchronously with the native artery at 4 weeks after implantation. However, all e-PTFE grafts occluded within the study period. The luminal surface of the PCL/PDO + 10%DY graft in the transitional zone was fully covered with endothelial cells as observed by SEM. Conclusion: The PCL/PDO + 10%DY graft was well tolerated, and no adverse tissue reaction was observed in porcine carotid models during the short-term follow-up. Colonization of the graft by host endothelial and smooth muscle cells coupled with substantial extracellular matrix production marked the regenerative capability. Thus, this material may be an ideal substitute for vascular reconstruction and bypass surgeries. Long-term observations will be necessary to determine the anti-thrombotic and remodeling potential of this device.

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Electrospun nanofibers for the fabrication of engineered vascular grafts

Cited by 39 publications

References 124 publications

A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds

A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model

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