Electrospun nanofibers for manipulating soft tissue regeneration

Abstract

Soft tissue damage is a common clinical problem that affects the lives of a large number of patients all over the world. It is of great importance to develop functional...

Microneedles for in situ tissue regeneration

“…The normal skin wound healing process includes hemostasis, inflammation, proliferation and tissue remodeling, involving various types of cells and bioactive factors [ 44 ]. Diseases such as diabetes, nasty skin tumors or infections can delay wound healing and eventually result in the development of chronic wounds [ 102 ]. In chronic wounds, the presence of scabs and microbial membranes, exudate drainage, and a hostile chemical microenvironment rich in various enzymes can undermine the therapeutic efficacy of topical drug delivery [ 103 ].…”

“…Common clinical treatments mainly include drug therapy, heart transplantation and left ventricular assist device implantation [ 158 ]. However, due to the limited regenerative capacity of the heart, existing treatments can only temporarily maintain cardiac function and do not repair infarcted myocardial tissue [ 102 ]. There are also disadvantages such as heart size mismatch, vascular lesions, and shortage of supply [ 158 ].…”

Electrospun nanofibrous membranes of recombinant human collagen type III promote cutaneous wound healing

“…37 RhCol III can be produced by fermenting genetically engineered microorganisms transfected with human genes, which results in products closer to human collagen in terms of molecular structure and properties, and suits mass production. 38 With a high porosity and surface-to-volume ratio, 39 nanofibrous materials utilized in wound treatment 40,41 possess a comparable physical structure to the natural ECM, 42,43 which expedites the regenerative process. Porous nanofibrous matrixes produced by electrospinning could mimic the ECM structure in the skin, offer a large surface area for cells, and increase the delivery of nutrients and oxygen.…”

“…With a high porosity and surface-to-volume ratio, 39 nanofibrous materials utilized in wound treatment 40,41 possess a comparable physical structure to the natural ECM, 42,43 which expedites the regenerative process. Porous nanofibrous matrixes produced by electrospinning could mimic the ECM structure in the skin, offer a large surface area for cells, and increase the delivery of nutrients and oxygen.…”

Carboxymethyl Chitosan-Functionalized Polyaniline/Polyacrylonitrile Nano-Fibers for Neural Differentiation of Mesenchymal Stem Cells

“…The nanofibrous nature of electrospun scaffolds mimics the structure and composition of collagen fibers within native ECM, which facilitates the migration, attachment, and proliferation of cells as well as the transition of nutrients and biochemical factors [13]. Meanwhile, the composition, morphology, structure, and 3D architecture of electrospun scaffolds can be easily controlled by choosing adequate material and processing parameters to regulate their biological functions and specific light/electric/magnetic properties [14]. Nanofibers with various dimeters (40-2000 nm) can be fabricated by choosing a suitable combination of polymers and solvents [13].…”