Electrospun Nanofibers for Drug Delivery

Stack, Mary; Parikh, Deep; Wang, Haoyu; Wang, Lichen; Meng, Xu; Zou, Jun; Cheng, Jun; Wang, Hongjun

doi:10.1016/b978-0-323-51270-1.00025-x

Cited by 17 publications

(13 citation statements)

References 123 publications

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“…This paper presents the results of an experimental study of a unique proportion of blend of polymers (PLGA and PEG) that were used to encapsulate targeted drugs (PGS-LHRH or PTX-LHRH) for the enhancement of sustained and localized delivery of targeted drugs for breast cancer treatment. This studies offer outstanding advantages that include targeted drug for controlled and prolong release period 54 . The in vitro drug release kinetics and thermodynamics with their degradation mechanisms were elucidated for micro-spherical drug-loaded polymer blends.…”

Section: Introductionmentioning

confidence: 99%

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Jusu

Obayemi

Salifu

et al. 2020

Sci Rep

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Triple-negative breast cancer (TNBC) is more aggressive and difficult to treat using conventional bulk chemotherapy that is often associated with increased toxicity and side effects. In this study, we encapsulated targeted drugs [A bacteria-synthesized anticancer drug (prodigiosin) and paclitaxel] using single solvent evaporation technique with a blend of FDA-approved poly lactic-co-glycolic acid-polyethylene glycol (PLGA_PEG) polymer microspheres. These drugs were functionalized with Luteinizing Hormone-Releasing hormone (LHRH) ligands whose receptors are shown to overexpressed on surfaces of TNBC. The physicochemical, structural, morphological and thermal properties of the drug-loaded microspheres were then characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), Nuclear Magnetic Resonance Spectroscopy (NMR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). Results obtained from in vitro kinetics drug release at human body temperature (37 °C) and hyperthermic temperatures (41 and 44 °C) reveal a non-Fickian sustained drug release that is well-characterized by Korsmeyer-Peppas model with thermodynamically non-spontaneous release of drug. Clearly, the in vitro and in vivo drug release from conjugated drug-loaded microspheres (PLGA-PEG_PGS-LHRH, PLGA-PEG_PTX-LHRH) is shown to result in greater reductions of cell/tissue viability in the treatment of TNBC. The in vivo animal studies also showed that all the drug-loaded PLGA-PEG microspheres for the localized and targeted treatment of TNBC did not caused any noticeable toxicity and thus significantly extended the survival of the treated mice post tumor resection. The implications of this work are discussed for developing targeted drug systems to treat and prevent local recurred triple negative breast tumors after surgical resection.

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Section: Introductionmentioning

confidence: 99%

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Jusu

Obayemi

Salifu

et al. 2020

Sci Rep

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“…In general, MPs are very similar to NPs in terms of their synthesis methods and applications, except for their size, which is bigger. Similar to NPs, MPs are commonly used to promote antimicrobial effects in different industries, and can be used as a drug delivery system due to their ability to protect from degradation bioactive drugs, proteins, and small molecules; they are also capable of controlling the release rate of encapsulated drugs over an extended period, up to months, and also, they are easily processed [89,91].…”

Section: Microparticlesmentioning

confidence: 99%

“…Microparticles (MPs) are spherical particles that range in size from 0.1 to 1000 µm and can be synthesized from natural and synthetic materials, such as polymers, glass, and ceramics. Similar to what happens with NPs, their small size gives them an advantage over larger particles (macroscale) and presents many desirable properties for a variety of different applications, such as drug delivery [89,90].…”

Section: Microparticlesmentioning

confidence: 99%

Metallic Structures: Effective Agents to Fight Pathogenic Microorganisms

Pereira

Carreira

Alves

et al. 2022

IJMS

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The current worldwide pandemic caused by coronavirus disease 2019 (COVID-19) had alerted the population to the risk that small microorganisms can create for humankind’s wellbeing and survival. All of us have been affected, directly or indirectly, by this situation, and scientists all over the world have been trying to find solutions to fight this virus by killing it or by stop/decrease its spread rate. Numerous kinds of microorganisms have been occasionally created panic in world history, and several solutions have been proposed to stop their spread. Among the most studied antimicrobial solutions, are metals (of different kinds and applied in different formats). In this regard, this review aims to present a recent and comprehensive demonstration of the state-of-the-art in the use of metals, as well as their mechanisms, to fight different pathogens, such as viruses, bacteria, and fungi.

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“…Crimped fibers have been used in energy harvesting applications . Core‐sheath fibers and side‐by‐side fibers have been used in the fields of drug delivery, healing and skin tissue engineering, and so on. Tri‐axial fibers exhibited good flexibility and outstanding mechanical properties .…”

Section: Introductionmentioning

confidence: 96%

A Review on the Secondary Surface Morphology of Electrospun Nanofibers: Formation Mechanisms, Characterizations, and Applications

2020

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Engineering the secondary surface morphology of fibers (fibers without smooth surface and solid interior) has been attracting significant awareness in various areas and applications. Among different methods of forming nanofibers, electrospinning is the most widely adopted technique due to the ease of forming fibers with a broad range of properties and its unique advantages such as the flexibility to spin into a variety of shapes and sizes as well as adjustable porosity of electrospun structures. In this review paper, more emphasis is put on the secondary surface morphology. A comprehensive overview of the basic principles about the electrospinning process, types of electrospinning, materials, formation mechanisms, characterizations, and applications of electrospun fibers with the secondary surface morphology (e. g. the porous structure, grooved structure, wrinkled structure, rough structure, cactus structure, and hollow structure) are discussed in detail. Importantly, we believe our work can serve as guidelines for the preparations, characterizations, and applications of electrospun fibers with the secondary surface morphology.

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Electrospun Nanofibers for Drug Delivery

Cited by 17 publications

References 123 publications

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Metallic Structures: Effective Agents to Fight Pathogenic Microorganisms

A Review on the Secondary Surface Morphology of Electrospun Nanofibers: Formation Mechanisms, Characterizations, and Applications

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