Electrospun nanofibers: A nanotechnological approach for drug delivery and dissolution optimization in poorly water-soluble drugs

Abstract

<jats:p>&lt;p class="ADMETabstracttext"&gt;Electrospinning is a novel and sophisticated technique for the production of nanofibers with high surface area, extreme porous structure, small pore size, and surface morphologies that make them suitable for biomedical and bioengineering applications, which can provide solutions to current drug delivery issues of poorly water-soluble drugs. Electrospun nanofibers can be obtained through different methods asides from the conventional one, such as coaxial, multi-jet, side by side, emulsion, and melt electrospinning. In general, the application of an electric potential to a polymer solution causes a charged liquid jet that moves downfield to an oppositely charged collector, where the nanofibers are deposited. Plenty of polymers that differ in their origin, degradation character and water affinity are used during the process. Physicochemical properties of the drug, polymer(s), and solvent systems need to be addressed to guarantee successful manufacturing. Therefore, this review summarizes the recent progress in electrospun nanofibers for their use as a nanotechnological tool for dissolution optimization and drug delivery systems for poorly water-soluble drugs.&lt;/p&gt;</jats:p>

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

“…Figure 5 shows the basic set-up, which consists of a feeding unit with a spinneret that transports the polymer solution until its tip, usually controlled by a pump [ 119 ]. A high-voltage supplier is connected to the spinneret and the collector, charging them oppositely.…”

“…The manufacturing process employed for scaffolds production can also improve drug physicochemical and biopharmaceutical properties that influence bioavailability [ 171 ]. Electrospinning improves the drug’s solubility through the amorphization of the API and the nanofiber’s high surface-to-volume ratio [ 119 ]. Llorens et al made use of this technology to successfully develop triclosan-loaded PLA/PEG scaffolds with tunable hydrophilicity and porosity [ 172 ].…”

Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

“…Electrospun nanofibers are of great interest to the biomedical and bioengineering industry due to their outstanding properties in terms of biocompatibility, biodegradability, and high drug-loading capacity to perform as drug delivery systems [104]. Regarding that, these nanofibers can be employed for the fabrication of scaffolds for wound healing that provide either an immediate or controlled release of the active pharmaceutical ingredient (API).…”

Development and Characterization of Drug‐Loaded PVP/PAN/Gr Electrospun Fibers for Drug Delivery Systems

“…The high surface area and small pore size of the fibers facilitate the rapid release of the active ingredients included in their structure [6] . Moreover, electrospun fibers are beneficial to increase the dissolution rate and solubility of drugs and poorly water‐soluble drugs in an amorphous state or as nanocrystals [3,4,7] . Especially, the electrospun fibers have attracted attention in the pharmaceutical field as drug carriers [2–12] …”