Development and Characterization of Drug‐Loaded PVP/PAN/Gr Electrospun Fibers for Drug Delivery Systems

Abstract

The objective of the present study is to evaluate the pH‐dependent drug release from polyvinylpyrrolidone (PVP)/polyacrylonitrile (PAN)/graphene (Gr) (P1) fibers using a quartz crystal microbalance (QCM). Electrospun fibers for poorly water‐soluble drugs were prepared on the QCM electrode surface through the electrospinning with P1 as the fiber‐forming polymer and drug carrier system and ibuprofen (Ibu) as the model drug. Characterization of the fibers is practiced by X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy in combination with energy‐dispersive X‐ray spectroscopy (SEM‐EDX), thermogravimetric analysis (TGA)‐differential scanning calorimetry (DSC), and water contact angle measurements. The in vitro release kinetic studies of the Ibu were studied using QCM and UV‐vis spectroscopy. The drug delivery properties of the fibers of PVP/PAN/Gr with 5 wt % Ibu (P2) and PVP/PAN/Gr with 10 wt % Ibu (P3) were measured at pH 5.4 and 7.4. In pH 5.4, the cumulative drug release of 19.5 % was procured from the P3 fiber within 24 h, on the other hand; the cumulative drug release of 16 % was acquired in pH 7.4.

Hydroxypropyl cellulose/Polyvinylpyrrolidone Matrix Tablets Containing Ibuprofen: Infiltration, Erosion and Drug Release Characteristics

“…The XRD pattern of HPC100‐IBU100, HPC80‐IBU100‐PVP20, HPC20‐IBU100‐PVP80 and PVP100‐IBU100 (Figure 12) depicted main peaks of ibuprofen at angles 2θ=16.4°/16.5°/16.3°/16.6°, 2θ =20.1°/20.1°/19.8°/20.1° and 2θ =22.1°/22.2°/21.9°/22.2°. It is suitable for the crystal structure of ibuprofen [78,79] . Although ibuprofen has high intensity crystalline peaks, it showed low intensity peaks in all powder blends due to dilution effects and the presence of amorphous PVP and semicrystalline HPC.…”

Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

“…Appropriate porosity and pore size of electrospun fibers may leverage essential cues to influence multiple cellular effects, including adhesion, proliferation, differentiation, and migration. Moreover, electrospun nanofibers may afford temporal and spatial release of biological cues, such as growth factors (GFs), peptides, and nucleic acid therapeutics to further facilitate tissue repair [ 57 , 58 , 59 , 60 , 61 , 62 ].…”