Electrospun Micropatterned Nanocomposites Incorporated with Cu₂S Nanoflowers for Skin Tumor Therapy and Wound Healing

Abstract

Surgical excision of skin cancers can hardly remove the tumor tissues completely and simultaneously result in cutaneous defects. To avoid tumor recurrence and heal the tumor-induced wounds, we designed a tissue engineering membrane possessing bifunctions of tumor therapy and skin tissue regeneration. The micropatterned nanocomposite membrane was successfully fabricated by incorporating CuS nanoflowers into biopolymer fibers via a modified electrospinning method. With uniformly embedded CuS nanoparticles, the membranes exhibited excellent and controllable photothermal performance under near-infrared irradiation, which resulted in high mortality (>90%) of skin tumor cells and effectively inhibited tumor growth in mice. Moreover, the membranes supported the adhesion, proliferation, and migration of skin cells as well as significantly stimulated angiogenesis and healed full-thickness skin defects in vivo. This proof-of-concept study offers a facile and reliable strategy for localized skin tumor therapy and tissue regeneration using bifunctional tissue engineering biomaterials, showing great promise for tumor-induced wound healing applications.

Bifunctional scaffolds for the photothermal therapy of breast tumor cells and adipose tissue regeneration

“…Therefore, achieving effective tumor ablation at a relatively low photothermal temperature is critical toward successful clinical application of PTT. 46 Besides the efficient photothermal ablation of tumor cells, adipose tissue regeneration is required to realize breast reconstruction to improve the quality of life of patients. The potential of the AuNRs-gelatin composite scaffolds for adipose tissue engineering was confirmed by examining their promotive effect on the adipogenic differentiation of hMSCs.…”

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

“…(1) In vitro study (2) In vivo wound model exposed to Escherichia coli [40] PLLA electrospun fibrous membranes (1) In vitro study (2) In vivo diabetic wound model [35] Cu 2 S Nanoflowers (1) In vitro study (2) In vivo diabetic wound model [36] CaCuSi 4 O 10 nanoparticles coated on the surface of Poly (ε-caprolactone) and Poly (D, L-lactic acid) (PP) fibers (1) In vivo diabetic wound model cancer surgerycaused wounds in tumor-bearing mice [37] Nerve tissue repair rGO In vivo spinal cord hemisection model [48] PLGA nanoparticles In vivo spinal cord hemisection model [45] Ischemia reperfusion GO (1) In vitro study (2) In vivo myocardial infarction model [49,50] Tetrahedral DNA nanostructures In vitro study [137] thus, the characteristics and slow-release structure of its specific ions are still unclear. An ideal scaffold for bone tissue engineering should promote vascularized bone formation.…”

“…On one hand, stress is supported by embedded nanofibres, so that the elasticity of matrix is reinforced. On the other hand, they have been demonstrated to improve the adhesion and proliferation of endothelial cells and promote angiogenesis [35][36][37][38].…”

Nanocomposite and biodegradable polymers applied to technical textiles

“…That is why various researchers have sought ways to reinforce this type of materials by incorporating nanoadditives that give rise to biocompatible and / or environmentally biodegradable polymeric nanocomposites. The most commonly used particles are pure hydroxyapatite, hydroxyapatite doped with some metal [16], calcium and phosphorus nanoparticles [17], tricalcium phosphate [18], copper sulphide [19], zinc oxide [20], oxide magnesium [21], strontium carbonate [22], montmorillonite [23], carbon nanotubes in conjunction with silver and iron nanoparticles [24], where each type of nanoparticle gives the polymer nanocomposite exclusive properties. Below are some examples of these types of compounds that have been used to generate technical textiles.…”