Electrospun matrices for localized drug delivery: Current technologies and selected biomedical applications

Meinel, Anne J.; Germershaus, Oliver; Lühmann, Tessa; Merkle, Hans P.; Meinel, Lorenz

doi:10.1016/j.ejpb.2012.01.016

Cited by 246 publications

(173 citation statements)

References 106 publications

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“…During the last decade electrospinning has emerged as an efficient technique to produce nano and micro diametersized fibers possessing a broad range of potential applications in the field of tissue regeneration [1][2][3][4][5][6][7][8]. A polymer solution, when electrostatically charged, can produce non-woven polymeric fibers in different size ranges by controlling the physical properties of the polymer solution and the spinning process conditions.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

et al. 2014

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Non-woven hybrid meshes based on poly(llactide-co-d,l-lactide) (dl-PLA) and β-tricalcium phosphate (β-TCP) were fabricated and comprehensively characterized. Stock suspensions of β-TCP powder in dl-PLA acetone solutions were used for the electrospinning process. Structure, morphology and thermal properties of the electrospun samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The electrospun hybrid materials show a micro-composite structure, and a morphology characterized by a three-dimensional porous fibrous mesh with randomly distributed fibers possessing average fiber diameters between 680 and 970 nm, uniform thickness along the fibers and beads structure only for higher β-TCP concentration electrospun samples. Both pure PLA and hybrid non-woven meshes exhibit a good thermal stability and a continuous degradation in simulated body fluid medium. A live/dead staining viability assay using MC3T3-E1 preosteoblasts reveals the excellent cytocompatibility of the fabricated non-wovens. Enhanced alkaline phosphatase (AP) activity of MC3T3-E1 cells during culture on the dl-PLA and the composite non-woven meshes demonstrates their potential for applications in hard tissue repair.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

et al. 2014

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“…There are four likely approaches of the drug in the resulting nanostructured materials [21] the drug may be envoy as particles to the surface of the polymer which is in the form of nanofibers or both the drug and the polymer are nanofiber-form, resulting in an end product whereby two kinds of nanofibers are interlaced together. Another prospect is that the blend of the drug and the polymer are integrated into one type of fiber containing both components.…”

Section: Drug-incorporation Techniques Via Electrospinningmentioning

confidence: 99%

“…For design calculation of diclofenac sodium in the path of a explanation of48 N-butyl hemiester of poly(maleic anhydride-alt-2-methoxyethylvinylether) in acetic acid modify the electrical conductivity of the solution, in which it turn caused a lessen in fiber diameters 49 On the another way an increase in fiber diameter was noted with adding upon meloxicam to PVA due to rise in solution viscosity. [21] Blending is a fairly simple procedure compared to other encapsulation ways such as emulsion or co-axial electrospinning. Though, a number of needs have to be met in order to attain the required results in expressions of drug release.…”

Section: Blendingmentioning

confidence: 99%

Recent Review on Nanofiber for Drug Delivery Systems

Singh¹

2017

WJPR

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“…In addition to nanoparticles, electrospun scaffolds have attracted considerable attention in recent years for their ability to deliver drugs in situ. 30,31 We consider that electrospun scaffolds have some critical advantages for local anticancer drug delivery after palliative surgery. First of all, scaffolding materials are usually synthetic polymers and/ or natural proteins with excellent in vivo biocompatibility, greatly defusing concerns about the cytotoxicity associated with the chemistry of delivery vehicles.…”

Section: In Vivo Antitumorigenic and Antimetastatic Effect Of Drug-elmentioning

confidence: 99%

“…[27][28][29] The fact that tissueengineered scaffolds can carry payloads, degrade in vivo, and are removed by metabolism make them appealing candidates as drug delivery vehicles. 30,31 Based on our clinical experience, we conceptualized that a drug-eluting scaffold can be grafted to cancer tissue remaining after palliative surgery for local delivery of FOLFIRINOX, a pancreatic chemotherapeutic regimen comprising oxaliplatin, leucovorin, irinotecan, and fluorouracil, to arrest tumorigenesis and metastasis. Based on our previous research, in this study we fabricated an electrospun scaffold composed of polyglycolide-co-trimethylene carbonate (PGA-TMC) and gelatin loaded with FOLFIRINOX, and evaluated its ability to arrest pancreatic tumorigenesis and metastasis in an orthotopic murine xenograft model.…”

Section: Introductionmentioning

confidence: 99%

Drug-eluting scaffold to deliver chemotherapeutic medication for management of pancreatic cancer after surgery

Zhan¹,

Shen²,

Deng³

et al. 2013

IJN

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Traditional post-surgical chemotherapy for pancreatic cancer is notorious for its devastating side effects due to the high dosage required. On the other hand, legitimate concerns have been raised about nanoparticle-mediated drug delivery because of its potential cytotoxicity. Therefore, we explored the local delivery of a reduced dosage of FOLFIRINOX, a four-drug regimen comprising oxaliplatin, leucovorin, irinotecan, and fluorouracil, for pancreatic cancer using a biocompatible drug-eluting scaffold as a novel chemotherapy strategy after palliative surgery. In vitro assays showed that FOLFIRINOX in the scaffold caused massive apoptosis and thereby a decrease in the viability of pancreatic cancer cells, confirming the chemotherapeutic capability of the drug-eluting scaffold. In vivo studies in an orthotopic murine xenograft model demonstrated that the FOLFIRINOX in the scaffold had antitumorigenic and antimetastatic effects comparable with those achieved by intraperitoneal injection, despite the dose released by the scaffold being roughly two thirds lower. A mechanistic study attributed our results to the excellent ability of the FOLFIRINOX in the scaffold to destroy the CD133 + CXCR4+ cell population responsible for pancreatic tumorigenesis and metastasis. This clinically oriented study gives rise to a promising alternative strategy for postsurgical management of pancreatic cancer, featuring a local chemotherapeutic effect with considerable attenuation of side effects.

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Electrospun matrices for localized drug delivery: Current technologies and selected biomedical applications

Cited by 246 publications

References 106 publications

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

Recent Review on Nanofiber for Drug Delivery Systems

Drug-eluting scaffold to deliver chemotherapeutic medication for management of pancreatic cancer after surgery

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