Recent Review on Nanofiber for Drug Delivery Systems

Singh, Amandeep

doi:10.20959/wjpr20174-8190

Cited by 6 publications

(14 citation statements)

References 24 publications

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“…In this method, solid fibers in the micro- or nanometer range are produced from a polymeric fluid stream or melt delivered through a millimeter-scale nozzle [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In the pharmaceutical field, electrospinning has recently gained high interest for the production of drug delivery systems based on nanofibers [ 31 , 32 , 33 , 34 , 35 ]. There are different approaches for loading drugs in electrospun fibers to obtain a controlled drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

“…There are different approaches for loading drugs in electrospun fibers to obtain a controlled drug delivery system. These include the following: (1) blending of the drug in the electrospinning polymer solution; (2) adsorption of drug molecules on the surface of electrospun fibers through physical interactions; (3) emulsion electrospinning, and (4) co-axial electrospinning [ 32 , 36 , 37 , 38 ]. The blending of drugs with the appropriate polymeric solution remains the most predominant method and is simple compared to others, but some requirements should be met in order to gain the desired results [ 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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Mats of polyvinyl alcohol (PVA) core–shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC) N4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core–shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. NMR spectroscopy and thermal analysis (TG/DTA) gave proof for the chemical integrity of the TSC in the fiber mats after the electrospinning process. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy showed no TSC on the surface of the PVA/TSC-PVA fibers confirming the core–shell character. The TSC release profiles of the fibers as studied using UV-vis absorption spectroscopy showed a slower release from the PVA/TSC-PVA core–shell structure compared with the monolithic PVA/TSC fibers as well as lower cumulative release percentage (17%). Out of several release models, the Korsmeyer–Peppas model gave the best fit to the experimental data. The main release phase can be described with a Fick-type diffusion mechanism. Antibacterial properties were tested against the Gram-positive Staphylococcus aureus bacterium and gave a minimal inhibitory concentration of 12.5 μg/mL. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT)-based cytotoxicity experiments showed that the cell viability of fibroblast at different contents of TSC was slightly decreased from 1.5% up to 3.5% when compared to control cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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“…This might be due to an interaction of the TSC and PLGA polymer in keeping with the idea that the small drug molecules can interfere with the ordering of the molecular chains and making them more mobile, which leads to the reduction of the glass transition temperature (T g ). 17 Differential thermal analysis (DTA) and thermogravimetry (TG) on the PLGA and PLGA-TSC-10 fibers ( Figure 3B,C , and 1454 cm −1 and were assigned to C H 2 , C H 3 and C H stretching vibrations of the functional groups of PLGA. [18][19][20] In the IR spectrum of the TSC there is a signal at 779 cm −1 attributed to the C S stretching.…”

Section: Resultsmentioning

confidence: 99%

“…14 Electrospinning is a convenient technique for producing fiber polymeric matrices from micro to nano-scale 15 and has recently gained much interest in the pharmaceutical field since it allows the facile production of nanofiber drug delivery systems. [16][17][18][19][20][21] The electrospinning technique provides considerable flexibility in selecting and combining materials and drugs. 20 The electrospun drug delivery system has significant advantages such as high encapsulation efficiency, simultaneous delivery of different drugs, and modulating drug-release profiles through surface modification of electrospun fibers with various chemical compounds.…”

mentioning

confidence: 99%

“…21 There are different approaches for loading drugs in electrospun fibers for obtaining a drug delivery system: (a) admixing the drug into the electrospinning polymer solution (b) adsorption of drug molecules on the surface of electrospun fibers; (c) emulsion electrospinning, and (d) co-axial electrospinning. 17,[22][23][24] For the therapeutic efficiency it is important to establish a sustained drug release and the design of the release system requires considerations on the physicochemical properties of the drug, the drug-polymer compatibility, formulation issues, and electrospinning processing parameters. 22 Poly(lactide-co-glycolide) (PLGA) is a random copolymer of poly(lactide) (PLA) and poly(glycolide) (PGA), 25,26 which is widely used for medical applications such as surgical suture thread, temporary scaffolds for tissue engineering, and as drug carriers.…”

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confidence: 99%

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Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Barani

Haseloer

Mathur

et al. 2020

Polymers for Advanced Techs

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Antibacterial fiber mats of poly(lactic-co-glycolic acid) (PLGA) were produced in the presence of different amounts of the thiosemicarbazone (TSC) N4-(S)-(1-phenylethyl)-2-(pyridin-2-ylmethylene)hydrazine-1-carbothioamide (HfpyTSCmB) through electrospinning. Increasing amounts (0, 2.5, 5, and 10 wt%) of TSC in the PLGA spinning solution in 2,2,2-trifluoroethanol (TFE) caused an increase up to 230% in conductivity and up to 27% in viscosity. The morphology of the electrospun fibers was studied using scanning electron microscope (SEM) and showed the formation of uniform, bead free, cylindrical, and smooth fiber mats. Increasing amounts of HfpyTSCmB in the polymer solution resulted also in significant shrinking of the diameter and narrowing of the size distribution of the fibers in line with the increased conductivity of the spinning solutions. Nuclear magnetic resonance (NMR) spectroscopy and thermal methods (DSC and TG/DTA) gave proof for the chemical integrity of HfpyTSCmB in the fiber mats after the electrospinning process. The release profile of HfpyTSCmB from the fibers was examined using UV-vis absorption spectroscopy. The observed release data during 21 days was fitted to different mathematical models with the best results obtained from the Higuchi release model. The fiber mat samples showed effective antibacterial properties with inhibition zones of 0.5 to 1.5 mm against the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli. K E Y W O R D S bacteriostatic properties, controlled drug release, nano fiber mats, PLGA, thiosemicarbazone 1 | INTRODUCTION There is an increasing demand for novel antimicrobial materials in many application areas, due to threatening human health with the growth of drug-resistant pathogens due to the biological and morphological modifications. This has led the high demand for novel drugs with enhanced, targeted activity. Thiosemicarbazones (TSC) are very promising molecules having interesting pharmacological properties with remarkable antioxidant, antiviral, antibacterial, anticancer, antitumor, antimalarial, ribonucleotide reductase enzyme inhibition, and antifungal activities when coordinated to metals but also in their absence. 1-7 TSC are synthesized through condensation of thiosemicarbazides with aldehydes or ketones. 1-3 The source thiosemicarbazides are synthesized either from secondary amines in a substitution reaction with methyl hydrazinecarbodithioate or from the addition of hydrazine to isothiocyanates. 6-13 TSC can act as ligands coordinating metal ions through their azomethine nitrogen and thiocarbonyl sulfur atoms (Scheme 1). The title TSC N4-(S)-(1-phenylethyl)-2-(pyridin-2-ylmethylene)hydrazine-1-carbothioamide (HfpyTSCmB) potentially coordinates metals through three (NNS)

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Multifunctional one-dimensional polymeric nanostructures for drug delivery and biosensor applications

et al. 2019

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Advances in nanotechnology in the last decades have paved the way for significant achievements in diagnosis and treatment of various diseases. Different types of functional nanostructures have been explored and utilized as tools for addressing the challenges in detection or treatment of diseases. In particular, one-dimensional nanostructures hold great promise in theranostic applications due to their increased surface area-to-volume ratios, which allow better targeting, increased loading capacity and improved sensitivity to biomolecules. Stable polymeric nanostructures that are stimuli-responsive, biocompatible and biodegradable are especially preferred for bioapplications. In this review, different synthesis techniques of polymeric onedimensional nanostructures are explored and functionalization methods of these nanostructures for specific applications are explained. Biosensing and drug delibiovery applications of these nanostructures are presented in detail.

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Recent Review on Nanofiber for Drug Delivery Systems

Abstract: ABSTRACT

Cited by 6 publications

References 24 publications

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Multifunctional one-dimensional polymeric nanostructures for drug delivery and biosensor applications

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