Electrospun materials as potential platforms for bone tissue engineering

Jang, Jun‐Hyeog; Castaño, Óscar; Kim, Hae‐Won

doi:10.1016/j.addr.2009.07.008

Cited by 445 publications

(351 citation statements)

References 110 publications

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“…In the case of n-HAp modified scaffolds, some bands characteristic of n-HAp were identified. Although the main m3 PO 4 3-stretching mode at about 1033 cm -1 was overlapped by the PCL spectrum, the m4 vibrational band was detected for nPCL/n-HAp and mPCL/n-HAp samples at 605 and 566 cm -1 [37]. The results confirmed a successful The contact angle measurement was performed in order to understand the influence of n-HAp on micro-and nanofibrous scaffolds' surfaces wetting ability.…”

Section: Resultssupporting

confidence: 51%

“…Recently, electrospinning of nanofibers has been widely researched and numerous composite nanofibers, containing bioactive molecules, have been prepared to match the requirements for bone tissue scaffolds [4][5][6]. Current developments include the fabrication of nanofibrous scaffolds which, due to their similarity to the extracellular matrix (ECM), can provide chemical, mechanical and biological signals to respond to the environmental stimuli [7].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Rajzer

2014

J Mater Sci

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In this study, two techniques, namely electrospinning and needle-punching processes, were used to fabricate bioactive polycaprolactone/hydroxyapatite scaffolds with a final bilayer nano-/micro-fibrous porous structure. A hybrid scaffold was fabricated to combine the beneficial properties of nanofibers and microfibers and to create a three-dimensional porous structure (which is usually very difficult to produce using electrospinning technology only). The first part of this work focused on determining the conditions necessary to fabricate nano-and micro-fibrous components of scaffold layers. A characterization of scaffold components, with respect to their morphology, fiber diameter, pore size, wettability, chemical composition and mechanical properties, was performed. Then, the same process parameters were applied to produce a hybrid bilayer scaffold by electrospinning the nanofibers directly onto the micro-fibrous nonwovens obtained in a traditional mechanical needle-punching process. In the second part, the bioactive character of a hybrid nano-/ micro-fibrous scaffold in simulated body fluid (SBF) was assessed. Spherical calcium phosphate was precipitated onto the nano-/micro-fibrous scaffold surface proving its bioactivity.

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Section: Resultssupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Rajzer

2014

J Mater Sci

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“…In order to prepare polymer solutions, PLA is dissolved in a solvent and is located in an ultrasonic bath for one hour ( Figure.1a). For this purpose, electro spinning device is used that includes a syringe pump to inject the polymer solution and a source of high voltage between collector surface and feeder pump (12). Initially, PLA polymer is dissolved within solvents tri flora ethanol (TFE).…”

Section: Structure Of Polymer Scaffolds Pla Using Electro Spinning Mementioning

confidence: 99%

The Possibility of Diabetic Wound Healing Using Electro spun PLA Nano Fibers

Majd¹,

Khorasgani²,

Mapar³

et al. 2017

JARB

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Diabetes is a metabolic disorder demonstrated by hyperglycemia and is typically resulted from defects in insulin secretion and impaired pancreatic function. In general, wound infection is a common complication of diabetes and finding effective remedies (medications) and methods of diabetic wound healing has recently been of interests of researchers. In the present research study, PLA NANO fiber scaffolds are prepared by electro spinning in two different concentrations of 2% and 4%. Indeed, electron microscopic scanning of this NANO fiber represents the achievement of NANO fibers with average diameter of 190 nm ± 44/4 nm and 460 nm ± 75 nm that encompass a uniform morphology. Given the fact that the PLA NANO fiber scaffolding with concentration of 2% has less average diameter, smaller pores and higher biodegradability, hence, it has been selected to study wound healing. In this study, 18 male Wistar rats weighing 250-280g are divided into three groups. First, two groups of rats become diabetic with streptozotocin (55mg / kg i.p.) and another group is monitored as a control type (healthy rats). After observing the symptoms of diabetes and hyperglycemia (250-300 mg /dl in diabetic group), a wound is made on the back of neck of all four groups with diameter of 1 cm through surgical scissors. Then, wound is treated in the experimental group on a daily basis for 14 days by PLA NANO fiber scaffolding. Meanwhile, macroscopic and microscopic studies are adopted on 0, 4, 7, 14 and 7, 14 days respectively. The results revealed wound size reduction, epidermal gap decrement and reduction in wound treatment area in the treatment group compared to it in healthy groups. This, in turn, implies the positive impact of the NANO fibers in the process of wound healing.

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“…[1][2][3][4] In the scaffolds, a parameter that is important factor of the scaffolds is constructive property such as surface area, porosity, and the percentage of void space. Pores are necessary for bone regeneration because that they permit for migration and proliferation of osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

Lim¹,

Oh²,

Choi³

et al. 2012

Polymer Korea

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For bone regeneration from KUSA-A1 oesteoblast cells (KUSA), chitosan (CS) scaffolds possessing different surface properties, sponge-type (CSS) and nonwoven-type (CSNW), were manufactured. Surface area and pore size of CSNW were larger than those of CSS. On the other hand, the pore volume of CSNW was smaller than that of CSS. Cell attachment evaluation showed CSNW was more adequate then CSS, and this was attributed to the large surface area. For in vivo investigation, KUSA were seeded into CS scaffolds in wells followed by a week of cell culture. Obtained CS scaffolds with KUSA were implanted on the subcutaneous tissue of BALB/C nude mice. After surgery, implanted scaffolds were harvested and assayed by immunological staining. Network stability of CSS was better than that of CSNW, even if CSS scaffolds were destroyed between 4 and 6 weeks. Calcification was observed after 4 and 8 weeks for CSNW and CSS, respectively.

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Electrospun materials as potential platforms for bone tissue engineering

Cited by 445 publications

References 110 publications

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

The Possibility of Diabetic Wound Healing Using Electro spun PLA Nano Fibers

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

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