Electrospun layered double hydroxide/poly (ε-caprolactone) nanocomposite scaffolds for adipogenic differentiation of adipose-derived mesenchymal stem cells

Shafiei, Seyedeh Sara; Shavandi, Mahnaz; Ahangari, Ghasem; Shokrolahi, Fatemeh

doi:10.1016/j.clay.2016.04.004

Cited by 43 publications

(33 citation statements)

References 35 publications

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“…Using scaffolds and nanoparticles together is a new approach in regenerative medicine for repairing defects [25,26]. For example Shafiei et al electrospun a kind of layered double hydroxide/poly (ε-caprolactone) nanocomposite scaffold and applied it for adipogenic differentiation of adipose-derived mesenchymal stem cells [27]. In another study which focused on bone differentiation, Karimi et al applied Baghdadite nanoparticle-coated with poly l-lactic acid (PLLA) ceramics electrospun scaffold which can improved osteogenic differentiation of adipose tissue-derived mesenchymal stem cells [1].…”

Section: Discussionmentioning

confidence: 99%

The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells

Mirakabad¹,

Hosseinzadeh²,

Abbaszadeh³

et al. 2019

Nano BioMed ENG

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Nowadays, bone repair by means of stem cells potential is considered as a new approach in regenerative medicine. Adipose-derived mesenchymal stem cells (AD-MSCs) have been investigated as a plentiful cell source with the ability of osteogenic differentiation which can play an important role in bone tissue engineering applications. Discovering proper elements in combination of scaffolds structure to stimulate osteogenesis in adipose-derived stem cells is one of the major concerns in this issue. Porous polymeric scaffolds such as polyacrylonitrile (PAN) and susceptible nanoparticles have attracted a lot of attention recently due to biodegradability and differentiation potential respectively. In the present study, clay-PAN nanocomposite (CPN) and graphene-PAN scaffold have been electrospuned separately and evaluated from the point of the osteogenic potential in AD-MSCs. The objective of this study was to determine the effect of clay and graphene nanoparticles with PAN nanofibers on the fate of viability and osteogenesis of AD-MSCs. First, isolated mesenchymal cells were characterized by flow cytometry. After cell culture on the surface of scaffolds MTT assay, scanning electron microscope (SEM) and DAPI staining were done. The scaffolds were characterized and osteogenic differentiation potential of AD-MSCs has been investigated. The results have indicated that alkaline phosphatase (ALP) activity, calcium content and collagen expression of cells which cultured on clay-PAN nanofibers were higher than cells which cultured on graphene-PAN scaffold. Taken together, these results suggest that porous nanofiber clay-PAN scaffold can enhance the osteogenic differentiation of AD-MSCs, and can be used as a new biodegradable scaffold for bone tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells

Mirakabad¹,

Hosseinzadeh²,

Abbaszadeh³

et al. 2019

Nano BioMed ENG

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“…In addition, the blending of PCL with other synthetic polymers with different properties for the preparation of polymer blends, after which the fabricated fillers can be introduced to the blends to afford PCL/blends composites with tremendous enhancement of the mechanical properties [79,83,84]. Table 4 summarizes the different solvent systems for electrospinning of PCL/filler nanocomposites and their mechanical properties [27,52,56,58,[62][63][64]67,72,80,82,[84][85][86][87][88][89]. Of all mechanical properties presented, modulus, tensile and strain, there was a discernible increase when the nanoclay is introduced at 1% and 5%.…”

Section: Mechanical Properties Of Electrospun Pcl and Its Compositesmentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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“…[160c,216] Ibuprofen, amoxicillin, flurbiprofen–axetil, and diclofenac intercalated LDH phases were uniformly dispersed in the polymer fibers to develop effective drug delivery systems. Recently, Shafiei et al highlighted that PCL/LDH electrospun fibers have a positive influence on cell adhesion, proliferation and differentiation, which could be of great interest for potential applications of such scaffolds in tissue engineering …”

Section: Hybrid Ldh Nanocompositesmentioning

confidence: 99%

Tailoring Hybrid Layered Double Hydroxides for the Development of Innovative Applications

Taviot-Guého

Prévot

Forano

et al. 2017

Adv Funct Materials

222

142

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International audienceHybrid materials based on layered double hydroxides (LDHs) exhibit great potential in diverse fields such as health care, polymer composites, environment, catalysis, and energy generation. Indeed, the compositional flexibility and the scalability of LDH structures, their low cost, and their ease of synthesis have made hybrid LDHs extremely attractive for constructing smart and high-performance multifunctional materials. This review provides a comprehensive and critical overview of the current research on multifunctional hybrid LDHs. Organic–inorganic hybrid LDHs, intercalated and surface-immobilized structures, are both specifically addressed. The new trends and strategies for hybrid LDH synthesis are first described, and then the potential of the latest hybrid LDHs, polymer LDH nanocomposites, and LDH bio-nanocomposites are presented. Significant achievements published from ≈2010, including authors' results, which employ hybrid LDH assemblies in materials science, medicine, polymer nanocomposites, cement chemistry, and environmental technologies, are specifically addressed. It is concluded with remarks on present challenges and future prospects

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Electrospun layered double hydroxide/poly (ε-caprolactone) nanocomposite scaffolds for adipogenic differentiation of adipose-derived mesenchymal stem cells

Cited by 43 publications

References 35 publications

The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells

The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Tailoring Hybrid Layered Double Hydroxides for the Development of Innovative Applications

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