Electrospun GelMA fibers and p(HEMA) matrix composite for corneal tissue engineering

Arıca, Tuğçe A.; Güzelgülgen, Meltem; Yıldız, Ahu Arslan; Demir, Mustafa M.

doi:10.1016/j.msec.2020.111720

Cited by 42 publications

(24 citation statements)

References 50 publications

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“…The peaks at ∼3300 and ∼1634 cm −1 corresponded to the stretching vibrations of the -OH and -CvO functional groups, respectively. 53 The peak at 1549 cm −1 in the FT-IR spectrum of pure GelMA, which corresponded to the amide -N-H bonds, was slightly shifted toward 1524 cm −1 in the spectrum of the GelMA-CQDs, suggesting the formation of hydrogen bonds between the -OH groups of the CQDs and -N-H groups of GelMA. Subsequently, the swelling and degradation behavior of each GelMA-CQD composite were investigated in the presence of phosphate-buffered saline (PBS) according to method described in section 2.5 (ESI †).…”

Section: Papermentioning

confidence: 96%

Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications

et al. 2022

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Section: Papermentioning

confidence: 96%

Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications

et al. 2022

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“…With the development of electrospinning technology and some breakthroughs in the medical field, the transparent fibrous membrane has been widely used in the biomedical field due to its simple production method and high specific surface area [ 121 , 122 ]. For example, the use of a highly transparent electrospinning fibrous membrane as wound dressing is conducive to doctors’ intuitive inspection of wound conditions and avoids secondary damage caused by frequent opening of the dressing [ 123 ].…”

Section: Application Of Transparent Electrospun Fibrous Membranementioning

confidence: 99%

Preparation and Applications of Electrospun Optically Transparent Fibrous Membrane

et al. 2021

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The optically transparent electrospun fibrous membrane has been widely used in many fields due to its simple operation, flexible design, controllable structure, high specific surface area, high porosity, and unique excellent optical properties. This paper comprehensively summarizes the preparation methods and applications of an electrospun optically transparent fibrous membrane in view of the selection of raw materials and structure modulation during preparation. We start by the factors that affect transmittance among different materials and explain the light transmission mechanism of the fibrous membrane. This paper also provides an overview of the methods to fabricate a transparent nanofibrous membrane based on the electrospinning technology including direct electrospinning, solution treatment after electrospinning, heat treatment after electrospinning, and surface modification after electrospinning. It further summarizes the differences in the processes and mechanisms between different transparent fibrous membranes prepared by different methods. Additionally, we study the utilization of transparent as-spun membranes as flexible functional materials, namely alcohol dipstick, air purification, self-cleaning materials, biomedicine, sensors, energy and optoelectronics, oil–water separation, food packaging, anti-icing coating, and anti-corrosion materials. It demonstrates the high transparency of the nanofibers’ effects on the applications as well as upgrades the product performance.

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“…To meet the demand for corneal transplantation, diverse bioengineering methods have been attempted to fabricate corneal substitutes based on synthetic (e.g., per uoropolyether (PFPE) [10], poly(vinyl alcohol) (PVA) [11,12], poly(ε-caprolactone) (PCL) [13,14], poly(methyl methacrylate) (PMMA) [15], poly(ethylene glycol) (PEG) [16], poly(hydroxyethyl methacrylate) (PHEMA) [17]or natural (e.g., silk [18], collagen [19,20], amniotic membranes [21], gelatin [17]) materials [22,23]. Furthermore, a combination of two or more synthetic and natural materials has been developed using 3D printing [24], electrospinning [13,17], and hydrogels [25]. The corneal stroma is the most central tissue of the cornea, making up two-thirds of its structure and accounting for about 90% of the corneal mass and thickness of the cornea [13].…”

Section: Introductionmentioning

confidence: 99%

PCL scaffold combined with rat tail collagen type I to reduce keratocyte differentiation and prevent corneal stroma fibrosis after injury

Kong

Xie

et al. 2022

Experimental Eye Research

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The cornea is one of the major refractive eye components with signi cant functions, and its transparency is essential for clear vision. With regard to corneal injury, the corneal epithelium has a strong self-healing ability, while the corneal stroma is not capable of total self-repair. Therefore, preventing brosis and reducing keratocyte differentiation after injury have always been a challenge. The severe shortage of donor corneas for transplantation and transplant rejection prompted the development of corneal tissue engineering. In this study, we fabricated a poly(ε-caprolactone) (PCL) micro brous scaffold and infused the scaffold with rat tail collagen type I to obtain a 3D composite material. The PCL/collagen scaffold was designed to fabricate an optimal construct that simulates the stromal structure with properties that are most similar to the native cornea. The PCL scaffold has good mechanical properties, and infusion with rat tail collagen type I improved its biocompatibility. The results demonstrate that 3D composite material could reduce keratocyte differentiation, help achieve regular collagen distribution, and promote corneal repair.NanoSupplementarymaterialsandmethods.docx

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Electrospun GelMA fibers and p(HEMA) matrix composite for corneal tissue engineering

Cited by 42 publications

References 50 publications

Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications

Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications

Preparation and Applications of Electrospun Optically Transparent Fibrous Membrane

PCL scaffold combined with rat tail collagen type I to reduce keratocyte differentiation and prevent corneal stroma fibrosis after injury

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