Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and <i>in vivo</i> wound-healing applications

Moniruzzaman, Md.; Dutta, Sayan Deb; Hexiu, Jin; Ganguly, Keya; Lim, Ki-Taek; Kim, Jongsung

doi:10.1039/d2bm00424k

Cited by 26 publications

(16 citation statements)

References 65 publications

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“…In another study, Moniruzzaman et al developed dual-emissive CQDs that were accommodated in a biocompatible gelatin–methacryloyl (GelMA) hydrogel. 149 The hydrogel provided 3D support for cell growth and proliferation at the wound site and the polyphenol CQDs were effective in reducing the amount of ROS induced by UV light. The aforementioned CQDs incorporated in GelMA promoted wound healing through the proliferation of fibroblasts, enhancing cell migration and reducing inflammation.…”

Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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“…After that, the fabricated hydrogel inks were transferred to a clean glass vial and irradiated with 365 nm UV light for 60 s. The concentration of CQDs was used as reported in our previous study. [ 21 ] The structural property of the pure GelMA and its composite hydrogel scaffolds was evaluated using FE‐SEM and the results are displayed in Figure S6 (Supporting Information). The freeze‐dried GelMA and GelMA‐CQD scaffold showed comparable microporous morphologies with unique porosity (Figure S6a, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation

Dutta

Ganguly

Hexiu

et al. 2023

Macromolecular Bioscience

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One of the significant challenges in bone tissue engineering (BTE) is the healing of traumatic tissue defects owing to the recruitment of local infection and delayed angiogenesis. Herein, a 3D printable multi‐functional hydrogel composing polyphenolic carbon quantum dots (CQDs, 100 µg mL−1) and gelatin methacryloyl (GelMA, 12 wt%) is reported for robust angiogenesis, bone regeneration and anti‐tumor therapy. The CQDs are synthesized from a plant‐inspired bioactive molecule, 1, 3, 5‐trihydroxybenzene. The 3D printed GelMA‐CQDs hydrogels display typical shear‐thinning behavior with excellent printability. The fabricated hydrogel displayed M2 polarization of macrophage (Raw 264.7) cells via enhancing anti‐inflammatory genes (e.g., IL‐4 and IL10), and induced angiogenesis and osteogenesis of human bone mesenchymal stem cells (hBMSCs). The bioprinted hBMSCs are able to produce vessel‐like structures after 14 d of incubation. Furthermore, the 3D printed hydrogel scaffolds also show remarkable near infra‐red (NIR) responsive properties under 808 nm NIR light (1.0 W cm−2) irradiation with controlled release of antitumor drugs (≈49%) at pH 6.5, and thereby killing the osteosarcoma cells. Therefore, it is anticipated that the tissue regeneration and healing ability with therapeutic potential of the GelMA‐CQDs scaffolds may provide a promising alternative for traumatic tissue regeneration via augmenting angiogenesis and accelerated immunomodulation.

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“…An extract of the leaves of UD rich in saponins, was studied for antioxidant activity, as antioxidant activity can help wound healing by regulating ROS [ 52 , 53 ]. Extract from the leaves of UD was found to have effective antioxidant activity (similar to ascorbic acid) that was important for wound healing activity of the extract [ 53 ].…”

Section: Antioxidant Potential Of Udmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

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Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

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Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications

Abstract: Upregulation of certain enzymes, such as collagenase, tyrosinase, and elastase, is triggered by several extrinsic environmental factors, such as temperature, UV radiation, humidity, and stress, and leads to elasticity loss...

Cited by 26 publications

References 65 publications

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

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