Electrospun dual-porosity structure and biodegradation morphology of Montmorillonite reinforced PLLA nanocomposite scaffolds

Lee, Yun Hui; Lee, Jong Hoon; An, In-Gu; Kim, Chan; Lee, Sang Soo; Lee, Youngkwan; Nam, Jae‐Do

doi:10.1016/j.biomaterials.2004.08.018

Cited by 271 publications

(147 citation statements)

References 28 publications

(45 reference statements)

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“…The porogens leach from the scaffold, leaving uniform pores dependent on the concentration and crystal size of the porogen [129]. Electrospun scaffolds created with the porogen leaching technique show significant cellular infiltration [64,[130][131][132]. Similar to porogen leaching, a soluble polymer and an insoluble polymer can be co-electrospun onto a central mandrel, followed by a rinse in dissolution media to dissolve the soluble fibers.…”

Section: Porogen and Sacrificial Fiber Incorporationmentioning

confidence: 99%

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

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Section: Porogen and Sacrificial Fiber Incorporationmentioning

confidence: 99%

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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“…Lee et al have combined electrospinning technology and salt leaching/gas foaming methods for the fabrication of an electrospun fibrous scaffold with dual-sized pores [61]. In addition to intrinsic pores formed between nanofibers, micro-sized pores created by salt particles are distributed in the scaffolds using this modified approach.…”

Section: Porositymentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

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“…Many researchers have engaged in fabricating multi-porous PLLA fiber membrane with various methods. Lee and his coworker [4] fabricated dual-porosity structure PLLA/MMT fibers by combining electrospinning with salt leaching method. Qi et al [5] fabricated PLLA fibers with micro-and nano-porous structure by electrospinning a ternary system of nonsolvent/solvent/PLLA.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and formation mechanism of poly (L-lactic acid) ultrafine multi-porous hollow fiber by electrospinning

Yu¹,

Qin²

2013

Express Polym. Lett.

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Abstract. Poly(L-lactic acid) (PLLA) ultrafine multi-porous hollow fibers are fabricated by electrospinning with methylene dichloride as solvent. The Kirkendall effect has been widely applied for the fabrication of hollow structure in metals and inorganic materials. In this study, a conceptual extension is proposed for the formation mechanism: the development of porous hollow fiber undergoes three stages. The initial stage is the generation of small voids or pits on the surface of the fiber via surface diffusion and phase separation; the second stage is the formation of multi-pores penetrating the core of the fiber through the interaction of Kirkendall effect, surface diffusion and phase separation; the third stage is dominated by surface diffusion of the core material along the pore surface. To explore the formation conditions, the factors including ambient temperature, relativity humidity (R. H.), molecular weight and fiber diameter are studied. The longitudinal and cross sectional morphologies of these fibers are examined by scanning electron micrograph (SEM). The results show that the prerequisite for the formation of uniform porous hollow PLLA fibers include moderate ambient temperature (10~20°C) and appropriate molecular weight for the PLLA, as well as the diameter of the fiber in the range of several micrometers to about 100 nanometers.

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Electrospun dual-porosity structure and biodegradation morphology of Montmorillonite reinforced PLLA nanocomposite scaffolds

Cited by 271 publications

References 28 publications

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Fabrication and formation mechanism of poly (L-lactic acid) ultrafine multi-porous hollow fiber by electrospinning

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