Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity

Tsekova, Petya; Spasova, Mariya; Manolova, Nevena; Маркова, Н.; Rashkov, Iliya

doi:10.1016/j.msec.2016.12.086

Cited by 96 publications

(53 citation statements)

References 35 publications

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“…In the literature , electrospinning of continuous CA nanofibers without beads used by a single solvent is not reported due to a wide range of technical challenges. Therefore, a variety of binary solvents with various ratios has been used such as Ac:water (3:1 and 4:1) , acetic acid:water (3:1) , acetic acid:Ac (1:1) , Ac:dimethyl sulfoxide (DMSO) (2:1) , dichloromethane (DCM):Ac (1:1, 3:1, and 5:1) , DMAc:DMSO (55:45) , Ac:DMAc (2:1) , and DCM: methanol (4:1) . In this work, it was found that the CA solution for the first time could be continuously electrospun nanofibers using binary solvents of Ac:DMAc (3:1).…”

Section: Resultsmentioning

confidence: 99%

Fabrication of lightweight and flexible cellulose acetate composite nanofibers for high‐performance ultra violet protective materials

Nasouri

2019

Polymer Composites

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Novel lightweight and flexible cellulose acetate (CA)/zinc oxide (ZnO)/multiwalled carbon nanotubes (MWCNTs) composite nanofibers were fabricated via electrospinning technique with aim to study the potential of such CA/ZnO/MWCNTs composite nanofibers as effective ultra violet (UV) protecting textile materials. The influence of ZnO and MWCNTs content and thickness of nanofibers mats on the ultra violet (UV) protection of electrospun CA/ZnO/MWCNTs composite nanofibers have been evaluated with response surface methodology (RSM) and quadratic regression model. The highest to lowest effects of selected parameters on UV protection values are ordered as follows: Thickness > > ZnO content > MWCNTs content. The optimized quadratic model predicted the highest UV protection value (UPF = 180.8) at conditions of 4.9 wt% ZnO content, 1.1 wt% MWCNTs loading, and 79.5 μm of the sample thickness. The obtained UV protection and photo‐degradation results established that the optimized quadratic model displayed appropriate performance for evaluating the involved input parameters and calculation of UV protection. POLYM. COMPOS., 40:3325–3332, 2019. © 2019 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 99%

Fabrication of lightweight and flexible cellulose acetate composite nanofibers for high‐performance ultra violet protective materials

Nasouri

2019

Polymer Composites

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“…In addition, the microstructure of single nanofiber also plays a critical role in drug release [121]. For example, Rashkov et al [122] developed a novel drug release system with cellulose acetate as "sea", polyvinylpyrrolidone containing curcumin as "islands" by twin-spin electrospinning. It was found that "sea-islands" structure tended to slow down the release of the drug significantly.…”

Section: Sustained Releasementioning

confidence: 99%

Electrospun Nanofibrous Materials for Wound Healing

et al. 2020

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Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired. Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this review article, we begin with a discussion of wound healing process and current commercial wound dressing materials. Then, we emphasize on electrospun nanofibrous materials for wound dressing, covering the efforts for controlling fiber alignment and morphology, constructing 3D scaffolds, developing waterproof-breathable membrane, governing drug delivery performance, and regulating stem cell behavior. Finally, we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.

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“…They may also be composed of materials with endogenous activity which play an active role in the healing process, by activating or driving cellular responses [57,58]. Various antibiotics, vitamins, proteins, minerals, enzymes, insulin, growth factors, cells, and antimicrobial agents have been used in this class of dressings to accelerate healing [26,29,59]. [11], with permission from Elsevier, 2020).…”

Section: Nanostructured Wound Dressingsmentioning

confidence: 99%

“…The introduction of chemical groups within the structure of cellulose has facilitated processing and contributed for the emergence of cellulose derivatives, like cellulose acetate (CA), which is the most common derivative that is considered by the European Committee for Standardization (CEN) as a bio-based polymer [23]. CA is a polymer that is easily soluble in common organic solvents, such as acetone, acetic acid, N,N-dimethylacetamide, and their mixtures, low-cost derivative of cellulose with excellent biocompatibility, high water adsorption capacities, good mechanical stability, non-toxicity, and can be efficiently processed into membranes, films, and fibers from either solutions or melts [21,[24][25][26][27][28]. Electrospinning allows for the production of CA-based nanomeshes with an intricate and complex architecture that can be functionalized with active biomolecules to address the specific demands of acute and chronic wounds via simple, reproducible and cost effective approaches [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity

Cited by 96 publications

References 35 publications

Fabrication of lightweight and flexible cellulose acetate composite nanofibers for high‐performance ultra violet protective materials

Fabrication of lightweight and flexible cellulose acetate composite nanofibers for high‐performance ultra violet protective materials

Electrospun Nanofibrous Materials for Wound Healing

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

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