Electrospun core–sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications

Abstract

Introduction: Drugs and biocompatible nanoparticles have raised significant potential in advancing the bone regeneration. Electrospinning technology enables the full realization of the value of drugs and nanoparticles.Methods: In this study, we have successfully fabricated core–sheath nanofibers solely composed of polycaprolactone (PCL) polymer. Simvastatin (SIM) was confined to the core of the nanofibers while nanohydroxyapatite (nHA) was loaded on the nanofiber surface.Results: All the prepared nanofibers exhibited a cylindrical micromorphology, and the core–sheath structure was exploited using a Transmission Electron Microscope. X-ray pattern results indicated that SIM was in an amorphous state within nanofibers, while Fourier Transform InfraRed spectroscopy showed excellent chemical compatibility among SIM, nHA, and PCL. The actual loading of nHA within the nanofiber was determined by a thermogravimetric test due to the high melting point of nHA. Core–sheath nanofibers could release SIM for 672 h, which was attributed to the core–sheath structure. Furthermore, nanofibers loaded with SIM or nHA had a positive impact on cell proliferation, with the core–sheath nanofibers displaying the most favorable cell proliferation behavior.Discussion: Such a synergistic facilitation strategy based on materials and nanostructure may encourage researchers to exploit new biomedical materials in future.

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

“…Later, double-fluid coaxial electrospinning and electrospraying became popular due to their ability to create core–shell structures, which can provide strong supports for developing numerous functional materials. 22–26 The double fluids can be arranged in an inner–outer manner or a side-by-side manner with the structural spinnerets (the right section of Fig. 1).…”

“…In general, there are two kinds of fundamental double-chamber nanostructures, i.e. , core–shell (or core–sheath, reflecting an inner–outer spatial relationship) 22–26 and Janus (or side-by-side, reflecting a front–rear, left–right, or up–down spatial relationship). 27–30 Other complicated multiple-chamber nanostructures can be viewed as combinations of these structures.…”

Superior performance of biocomposite nanoparticles PLGA-RES in protecting oocytes against vitrification stimuli

“…Nanobiotechnology has been used in a wide range of biomedical applications, including bio-detection, drug delivery and diagnostic imaging, particularly in the area of cancer diagnosis and treatment ( Wang et al, 2021 ). Even some popular nanobiotechnology, such as electrospinning ( Qian et al, 2023 ; Wang et al, 2023 ; Duan et al, 2024 ) and electrospray ( Sun et al, 2023 ; Zhou et al, 2023 ), make it easier and more efficient to produce nanofiber/microparticle for disease treatment. In the last decades, many synthetic polymers have been investigated for nanomedical applications, especially as drug delivery systems.…”

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

“…[39][40][41] Meanwhile, the EHDA processes are frequently categorized by the spinneret, e.g. a concentric spinneret corresponds to a coaxial electrospinning or coaxial electrospraying process; [42][43][44] an eccentric spinneret corresponds to a side-by-side electrospinning or side-by-side electrospraying. [45,46] Today, nanoscience is moving forward in three directions, i.e., smaller (pico-technology), more order (such as various kinds of arrays), and complex structures and devices.…”