Electrospun Contrast‐Agent‐Loaded Fibers for Colon‐Targeted MRI

Jin, Miao; Yu, Deng‐Guang; Wang, Xia; Geraldes, Carlos F. G. C.; Williams, Gareth R.; Bligh, S. W. Annie

doi:10.1002/adhm.201500872

Cited by 62 publications

(58 citation statements)

References 55 publications

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“…These nanofiber mats have both large surface area , 3D web structures with huge porosity [16,17]. For the cylindrical nanofibers, their volume (V) can be roughly calculated according to the following concept.…”

Section: A Calculation About the Surface Enlargement From 1d Nanofibersmentioning

confidence: 99%

Simple Calculations but Amusing Lessons about Teaching Nanotechnology in Higher Education

Wang¹,

Sun²,

Liu³

et al. 2017

dtssehs

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Abstract. The higher education should follow closely the fast development of modern science and technology. Particularly in those disciplines about engineering and applied sciences, the lessons about state-of-the-art techniques are very important to cultivate the students' innovation ability and capability of solving the complex engineering problems. However, how to effectively teach these contents needs careful considerations. Here, it is demonstrated that the simple calculations can achieve amusing results about the lessons on nanotechnologies such as electrospinning and electrospraying. The surface enlargement effects of nanomaterials including 2-dimensional graphene, 1-dimensional electrospun nanofiber, and 0-dimensional nanoparticle are calculated. All the calculation demonstrate that the magnitude of surface area increase is equal to the magnitude the size decrease. These simple calculations can be good start points for giving lessons about nanotechnologies to college students, can make the courses more vivid, and can provoke the students' interests about new kinds of advanced techniques.

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Section: A Calculation About the Surface Enlargement From 1d Nanofibersmentioning

confidence: 99%

Simple Calculations but Amusing Lessons about Teaching Nanotechnology in Higher Education

Wang¹,

Sun²,

Liu³

et al. 2017

dtssehs

Self Cite

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“…29 In comparison with the relaxivities of fibers loaded with Gd(DTPA) only (Tables S2 and S3), those of Gd(DTPA)/indomethacin fibers were found to be somewhat lower (e.g. F3 has r 1 =10.13 s -1 mM -1 and r 2 =14.69 s -1 mM -1 , while the indomethacin-free analogue F3' has r 1 =12.29 s -1 mM -1 and r 2 =18.68 s -1 mM -1 ).…”

Section: Proton Relaxivitiesmentioning

confidence: 99%

“…29 Gd(DTPA) was found to retain its ability to act as contrast agent after electrospinning. It was also demonstrated that functional ingredients embedded in the core of the fibers can be effectively transferred to the colonic mucosa, permitting the latter to be imaged.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Jin

Geraldes

et al. 2016

Mol. Pharmaceutics

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Abstract:New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnostic and targeting agents are much sought after. This work reports for the first time the use of coaxial electrospinning to prepare such systems in the form of core-shell fibers. Eudragit S100 was used to form the shell of the fibers, while the core comprised polyethylene oxide loaded with the magnetic resonance contrast agent Gd(DTPA) (Gd(III) diethylenetriaminepentaacetate hydrate) and indomethacin as a model therapeutic agent. The fibers had linear cylindrical morphologies with clear core-shell structures, as demonstrated by electron microscopy. X-ray diffraction and differential scanning calorimetry proved that both indomethacin and Gd(DTPA) were present in the fibers in the amorphous physical form. This is thought to be a result of intermolecular interactions between the different components, the presence of which was suggested by IR spectroscopy. In vitro dissolution tests indicated that the fibers could provide targeted release of the active ingredients through a combined mechanism of erosion and diffusion. The proton relaxivities for Gd(DTPA) released from the fibers into tris buffer increased (r 1 =5.03-10.13 s -1 mM -1 ; r 2 =8.28-14.96 s -1 mM -1 ) compared with fresh Gd(DTPA) (r 1 =4.37 s -1 mM -1 and r 2 =4.85 s -1 mM -1 ), proving that electrospinning has not diminished the contrast properties of the complex. The new systems reported herein thus offer a new platform for delivering therapeutic and imaging agents simultaneously to the colon.

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“…But this concept has a very close relationship with a series of instrumental analyses [20][21]. Good compatibility is prerequisite for the designed materials, for their storage or reactions, so that the vessel and other apparatus will not be damaged by its contents.…”

Section: High Correlation Between the "Compatibility" And The Inmentioning

confidence: 99%

Lessons from Explaining lCompatibilityr to college students for Instrumental Education with FTIR as an Example

Yang¹,

Gu²,

Chen³

et al. 2018

Proceedings of the 2018 2nd International Conference on Management, Education and Social Science (ICMESS 2018)

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Abstract-Instrumental education is a very important part in colleges and universities, which has a profound influence on cultivating the ability of undergraduates, particularly the ability of combine theory with practice. In this paper, compatibility, as a key hidden element in the design of suitable materials, particularly composite materials, is explored as a professional term in instrumental education. The clear disclosure and explanations of "compatibility" to college students should be beneficial to improve students' comprehensive ability, particularly the ability of "combining theory with practice". Although only Fourier-transform infrared spectroscopy (FTIR) has been innovatively developed here, a series of other characterization methods can be similarly explored as teaching materials for cultivating students' comprehensive ability during the scientific instrumental educations processes.

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Electrospun Contrast‐Agent‐Loaded Fibers for Colon‐Targeted MRI

Cited by 62 publications

References 55 publications

Simple Calculations but Amusing Lessons about Teaching Nanotechnology in Higher Education

Simple Calculations but Amusing Lessons about Teaching Nanotechnology in Higher Education

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Lessons from Explaining lCompatibilityr to college students for Instrumental Education with FTIR as an Example

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