“…The products that are now available (even commercially), are hydro-gels and 3D surfaces, composed of specific constituents of original extra-cellular matrices (extractive or synthetic origin), and solid supports (micro-carriers or scaffolds, also pre-shaped), made up of porous, bio-compatible, organic or synthetic components. Examples of the sophisticated models that, for various purposes, have been obtained from primary hepatocytes, are those generated by using bio-degradable nano-structured substrates (Kim et al, 1998), heat-sensitive polymers (Ohashi et al, 2007), various 3D matrices (Fiegel et al, 2008;ZQ. Feng et al, 2010;Ghaedi et al, 2012), or synthetic self-assembling hydrogels (Wang et al, 2008).…”