Nanofibrous Structure of Chitosan for Biomedical Applications

Bhattarai, Narayan

doi:10.4172/2155-983x.1000102

Cited by 9 publications

(4 citation statements)

References 90 publications

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“…Deepthi et al [59] and Mahoney et al [60] review the applications of chitin-and chitosan-based nanocomposites for construction of scaffolds for bone tissue engineering. Chitin and chitosan are ideal materials for bone tissue engineering because of their biocompatibility, biodegradability, non-antigenicity, structural similarity to glycosaminoglycans (major components of the extracellular matrix of the bone), ability to form highly porous scaffolds with interconnected pores, ability to enhance bone formation and osteoconductivity.…”

Section: Nanotechnology In Bone Tissue Engineeringmentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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The application of nanotechnology in medicine, diagnostics, therapeutics, drug delivery, etc. in order to overcome the limitations faced by these fields has already been established. Anaemia and osteoporosis are two of the most widely prevalent iron and calcium deficiency diseases among women. Conventional drugs for both have their inherent limitations which can be overcome by nanotechnology. Nanonization of drugs has been established as a very efficient way to enhance the bioavailability and absorption of the drug in the gastrointestinal tract. In addition to this, encapsulation of drugs in solid lipid nanoparticles is also employed to increase the stability of the drug in the gastrointestinal tract and to facilitate its controlled release. Nanotechnology is also applied in bone tissue engineering to prepare bone grafts for bone injury. Nanotechnology-based bone grafts have shown to possess enhanced mechanical properties and better biocompatibility and osteoconduction than the conventional bone grafts. This review article highlights the research trends and challenges of nanotechnology based drugs to combat iron deficiency anaemia and osteoporosis. This review outlines the recent research trends in nano-drugs and touches on issues concerning the market, industries and patents pertaining to drugs for anaemia and osteoporosis. To provide the safety and risk factors of nanomaterials, we have briefly highlighted the toxicological aspects of nanomaterials used in drugs.

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Section: Nanotechnology In Bone Tissue Engineeringmentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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“…Chitosan is naturally available in abundance and shows admirable properties such as biodegradability, antibacterial and antifungal activity, nontoxicity, hemostasis, environment-friendliness, and biocompatibility, which makes it suitable for many biomedical applications. [47][48][49] It is studied that pure chitosan can be dissolved in nonaqueous solvents such as triflouroacetic acid (TFA). 50 But due to crystalline structure, hydrogen bonding, and repeating units of D-glucosamine, it is very difficult to obtain a homogeneous solution, but homogeneity can be improved by adding dichloromethane in solution.…”

Section: Chitosanmentioning

confidence: 99%

Sustainable nanofibers in tissue engineering and biomedical applications

Malik

Sundarrajan

Hussain

et al. 2020

Mat Design & Process Comms

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The practice of using a massive amount of environmental unfriendly and toxic petroleum-based materials in tissue engineering and biomedical fields demands the materials, which are biodegradable, renewable, environmentally friendly, biocompatible, and bioactive. So, renewable polymers have got considerable attention due to their numerous desirable properties. The nanofibers that are prepared from renewable materials and their blends can integrate the properties of both nanofibers and renewable polymers. Development of scaffolds that mimic the construction of tissues at nanoscale is a great challenge for tissue engineering. Electrospinning is the most promising technique for nanofibers formation. Nanofibers provide a platform for cell adhesion, proliferation, and differentiation. Therefore, nanofibers from sustainable materials have been used in tissue engineering and biomedical fields. In this review, methods for nanofibers fabrication, sustainable nanofibers made from natural and synthetic polymers and their applications in tissue engineering and biomedical field, have been emphasized.

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“…Polymeric hybrid nanofibers are gaining popularity among biomaterial researchers and industries because of their outstanding functional properties [1,2]. These hybrid nanofibers exhibit excellent mechanical and biological properties, which make them very attractive for various biomedical applications, such as tissue engineering scaffolds, wound dressings devices, drug delivery materials, medical implants, biosensors and filtration devices [1].…”

Section: Introductionmentioning

confidence: 99%

“…These hybrid nanofibers exhibit excellent mechanical and biological properties, which make them very attractive for various biomedical applications, such as tissue engineering scaffolds, wound dressings devices, drug delivery materials, medical implants, biosensors and filtration devices [1]. Nanofibrous structures give rise to a high surface area-to-volume ratio similar to that of proteoglycans (glycosaminoglycan) and fibrous proteins, which comprise the ECM of living tissue [3,4].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun PCL-MgO-Keratin-Based Composite Nanofibers for Biomedical Applications

et al. 2015

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Polymeric nanofibers are of great interest in biomedical applications, such as tissue engineering, drug delivery and wound healing, due to their ability to mimic and restore the function of natural extracellular matrix (ECM) found in tissues. Electrospinning has been heavily used to fabricate nanofibers because of its reliability and effectiveness. In our research, we fabricated poly(ε-caprolactone)-(PCL), magnesium oxide-(MgO) and keratin (K)-based composite nanofibers by electrospinning a blend solution of PCL, MgO and/or K. The electrospun nanofibers were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), mechanical tensile testing and inductively-coupled plasma optical emission spectroscopy (ICP-OES). Nanofibers with diameters in the range of 0.2–2.2 µm were produced by using different ratios of PCL/MgO and PCL-K/MgO. These fibers showed a uniform morphology with suitable mechanical properties; ultimate tensile strength up to 3 MPa and Young’s modulus 10 MPa. The structural integrity of nanofiber mats was retained in aqueous and phosphate buffer saline (PBS) medium. This study provides a new composite material with structural and material properties suitable for potential application in tissue engineering.

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Nanofibrous Structure of Chitosan for Biomedical Applications

Cited by 9 publications

References 90 publications

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Sustainable nanofibers in tissue engineering and biomedical applications

Fabrication and Characterization of Electrospun PCL-MgO-Keratin-Based Composite Nanofibers for Biomedical Applications

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