Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts

Charernsriwilaiwat, Natthan; Rojanarata, Theerasak; Ngawhirunpat, Tanasait; Sukma, Monrudee; Opanasopit, Praneet

doi:10.1016/j.ijpharm.2013.05.012

Cited by 139 publications

(68 citation statements)

References 35 publications

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“…These findings showed that the antioxidant activity of PM5, PM7, and PM10 composite nanofibers was higher than the GME although it had been exposed to high voltages during the electrospinning process. This result corroborated that the previous study that the antioxidant activity of GME was not affected by the electrospinning process [39].…”

Section: Antioxidant Activitiessupporting

confidence: 93%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

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Section: Antioxidant Activitiessupporting

confidence: 93%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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“…Currently, electrospinning is the latest technology for the fabrication of novel biomaterials. 39 In comparison with conventional methods of freeze drying that have been employed for the fabrication of chitosan skin templates, electrospinning produces nanofibrillar structures. Nanofiber biomaterials provide better substrates for cell adhesion, proliferation, and differentiation in 3D culture.…”

Section: Discussionmentioning

confidence: 99%

A Bilayer Engineered Skin Substitute for Wound Repair in an Irradiation-Impeded Healing Model on Rat

Hilmi

Hassan

Halim

2015

Advances in Wound Care

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Objective: An engineered skin substitute is produced to accelerate wound healing by increasing the mechanical strength of the skin wound via high production of collagen bundles. During the remodeling stage of wound healing, collagen deposition is the most important event. The collagen deposition process may be altered by nutritional deficiency, diabetes mellitus, microbial infection, or radiation exposure, leading to impaired healing. This study describes the fabrication of an engineered bilayer skin substitute and evaluates its effectiveness for the production of collagen bundles in an impaired healing model. Approach: Rats were exposed to 10 Gy of radiation. Two months postirradiation, the wounds were excised and treated with one of three skin replacement products: bilayer engineered skin substitutes, chitosan skin templates, or duoderm ª . The collagen deposition was analyzed by hematoxylin and eosin staining. Results: On day 21 postwound, the irradiated wounds displayed increased collagen bundle deposition after treatment using bilayer engineered skin substitutes (3.4 -0.25) and chitosan skin templates (3.2 -0.58) compared with duoderm (2.0 -0.63). Innovation: We provide the first report on the fabrication of bilayer engineered skin substitutes using high density human dermal fibroblasts cocultured with HFSCs on chitosan skin templates. Conclusion: The high density of fibroblasts significantly increases the penetration of cells into chitosan skin templates, contributing to the fabrication of bilayer engineered skin substitute.

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“…Recently, composite chitosan fibres with enhanced antibacterial properties have been prepared using natural bioactive compounds, such as essential oils and honey. [97][98][99][100] Cinnamon oil has been incorporated into chitosan/poly(ethylene oxide) (PEO) fibres having a diameter of around 50 nm. 97 The electrospun mats were able to release the essential oil in vitro, and exhibited antibacterial activity against E. coli and P. aeruginosa.…”

Section: Chitosanmentioning

confidence: 99%

“…In another work, extracts of Garcinia mangostana (GM), a tropical fruit, were added to chitosan-ethylenediaminetetraacetic acid/polyvinyl alcohol (CS-EDTA/PVA) solutions and electrospun. 98 The scaffolds possessed antioxidant and antibacterial activity (E. coli and S. aureus), and were effective in accelerating wound healing in rats, with a wound closure rate higher than commercial antibacterial dressings. Sarhan et al have produced honey/chitosan/PVA fibres loaded with Cleome droserifolia (CE) and Allium sativum extracts.…”

Section: Chitosanmentioning

confidence: 99%

Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

2016

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Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts

Cited by 139 publications

References 35 publications

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

A Bilayer Engineered Skin Substitute for Wound Repair in an Irradiation-Impeded Healing Model on Rat

Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

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