Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

Wei, Zhimei; Wang, Liqun; Zhang, Shouyu; Chen, Tonghai; Yang, Jie; Long, Shengru; Wang, Xiaojun

doi:10.1142/s1793545820300128

Cited by 30 publications

(15 citation statements)

References 58 publications

(48 reference statements)

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“…One of the major causes of chronic infections can be linked to bacterial infections [48][49][50][51], which fester at a very high rate in existing wounds; thus, the need to use antibacterial materials is of paramount importance. With a large surface area, antibacterial nanofibers allow for the efficient integration of antibacterial agents [52]. In recent years, nanotechnology has advanced at a blistering pace.…”

Section: Antibacterial Nanofibers For Wound Dressingmentioning

confidence: 99%

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

et al. 2021

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Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

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Section: Antibacterial Nanofibers For Wound Dressingmentioning

confidence: 99%

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

et al. 2021

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“…Scaffolds have found applicability in tissue engineering, where the materials are fabricated into artificial tissue that stimulates growth factors and enhances tissue regeneration. Among these materials, nanofibers possess a unique structure of small pore size and high porosity, thus protecting wounds from infections and ensuring unrestricted transportation of gas and liquid molecules [ 15 , 16 ]. Due to their unique properties, additional biomedical applications of nanofibers to wound dressing include drug delivery, vascular grafts, artificial organs, and tissue engineering [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives

Akombaetwa¹,

Bwanga²,

Makoni

et al. 2022

Polymers

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Wounds are a consequence of disruption in the structure, integrity, or function of the skin or tissue. Once a wound is formed following mechanical or chemical damage, the process of wound healing is initiated, which involves a series of chemical signaling and cellular mechanisms that lead to regeneration and/or repair. Disruption in the healing process may result in complications; therefore, interventions to accelerate wound healing are essential. In addition to mechanical support provided by sutures and traditional wound dressings, therapeutic agents play a major role in accelerating wound healing. The medicines known to improve the rate and extent of wound healing include antibacterial, anti-inflammatory, and proliferation enhancing agents. Nonetheless, the development of these agents into eluting nanofibers presents the possibility of fabricating wound dressings and sutures that provide mechanical support with the added advantage of local delivery of therapeutic agents to the site of injury. Herein, the process of wound healing, complications of wound healing, and current practices in wound healing acceleration are highlighted. Furthermore, the potential role of drug-eluting nanofibers in wound management is discussed, and lastly, the economic implications of wounds as well as future perspectives in applying fiber electrospinning in the design of wound dressings and sutures are considered and reported.

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“…However, traditional antimicrobial dressings also exhibit many limitations, including the inability to absorb excess wound exudate, severe adhesion to tissue, and poor microbial isolation [15,16]. Therefore, plans to develop new dressings are urgently needed [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Chitosan‐Based Nanosilver Composites for the Repair of Umbilical Cord Wounds in Newborns

Peng

Gong

2022

Journal of Nanomaterials

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The study aim reports a new umbilical cord wound repair material based on modified chitosan-based nanosilver (CS-HDH/Ag NPs). The repair of umbilical cord wound has always been the focus of neonatal departments. The study method chitosan, which is famous for its “biological glue,” is used as a modifier to compound silver nanoparticles with strong coordination and adsorption capacity of chitosan. It is worth noting that CS-HDH/Ag NPs has a significant inhibitory effect on common bacterial infection and reduces the incidence of umbilical cord wound inflammation. The study problem wound bleeding and stump shedding and other factors make the periumbilical cord vulnerable to bacterial infection. For study results, the porous and lamellar structure endows the repair material with breathable properties and excellent antiadhesion, which greatly reduces the number of dressing changes and effectively protects the skin of newborns. CS-HDH/Ag NPs provides a new model for efficient neonatal health management.

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Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

Cited by 30 publications

References 58 publications

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives

Analysis of Chitosan‐Based Nanosilver Composites for the Repair of Umbilical Cord Wounds in Newborns

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