Electrospun Aligned PCL/Gelatin Scaffolds Mimicking the Skin ECM for Effective Antimicrobial Wound Dressings

Ghomi, Erfan Rezvani; Lakshminarayanan, Rajamani; Chellappan, Vijila; Verma, Navin Kumar; Chinnappan, Amutha; Neisiany, Rasoul Esmaeely; Kottaiswamy, Amuthavalli; Poh, Zhi Sheng; Wong, Brandon Han Siang; Dubey, Nileshkumar; Narayan, Roger J.; Ramakrishna, Seeram

doi:10.1007/s42765-022-00216-w

Cited by 60 publications

(40 citation statements)

References 53 publications

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“…The aligned nanofibers were found with smaller diameters than the random nanofibers. At higher rotation speeds of the collector, the generated higher tensile forces lead to smaller fiber diameters …”

Section: Resultsmentioning

confidence: 99%

“…At higher rotation speeds of the collector, the generated higher tensile forces lead to smaller fiber diameters. 40 The conductivity of aligned PCNFs was adjustable and depended on the concentration of pyrrole for polymerization. As shown in Figure S2, the resistance of PCNFs decreased rapidly when the pyrrole concentration increased from 0.05 to 0.9 M. Notably, the resistance of PCNF-4 was not significantly different from that of PCNF-3.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Highly Aligned Cellulose/Polypyrrole Composite Nanofibers via Electrospinning and In Situ Polymerization for Anisotropic Flexible Strain Sensor

Song

et al. 2023

ACS Appl. Mater. Interfaces

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Flexible strain sensors have recently attracted great attention due to their promising applications in human motion detection, healthcare monitoring, human–machine interfaces, and so forth. However, traditional uniaxial strain sensors can only detect strain in a single direction. Herein, an anisotropic flexible strain sensor is fabricated based on conductive and highly aligned cellulose composite nanofibers, via facile electrospinning cellulose acetate, deacetylation, and in situ polymerization of pyrrole, to detect complex multidimensional strains. Benefiting from the unique well-ordered structure of conductive composite nanofibers, the obtained strain sensor shows extraordinary anisotropic sensing performance with a sensitivity of 0.73 and 0.01 for the tensile applied perpendicular and parallel to the nanofiber alignment, respectively. The sensor also exhibits outstanding durability (2000 cycles) due to the strong hydrogen bonding between cellulose nanofibers and polypyrrole. Moreover, the flexible strain sensors exhibit promising potentials for application in motion detection, as demonstrated by the detection of various joint movements in the human body.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Highly Aligned Cellulose/Polypyrrole Composite Nanofibers via Electrospinning and In Situ Polymerization for Anisotropic Flexible Strain Sensor

Song

et al. 2023

ACS Appl. Mater. Interfaces

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“…The first group are designed for in situ drug release, such as anti-inflammatory, pain relief and anti-bacterial solutions, and can be described as a treatment for symptoms and external impurities [ 75 ]. The second group of bandages are classified as bio-active bandages that assist with endogenous activity by actively enhancing tissue regeneration and the body’s healing processes [ 76 , 77 , 78 , 79 ]. These bandages are an early example of drug delivery mechanisms that as a result of the immense amount of research in the last two decades, will become electronically controlled via surrounding stimuli, such as light, temperature or skin chemistry [ 80 , 81 ], or via directly received digital input [ 82 , 83 ].…”

Section: Functional Bandagesmentioning

confidence: 99%

Wearable Smart Bandage-Based Bio-Sensors

2023

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Bandage is a well-established industry, whereas wearable electronics is an emerging industry. This review presents the bandage as the base of wearable bioelectronics. It begins with introducing a detailed background to bandages and the development of bandage-based smart sensors, which is followed by a sequential discussion of the technical characteristics of the existing bandages, a more practical methodology for future applications, and manufacturing processes of bandage-based wearable biosensors. The review then elaborates on the advantages of basing the next generation of wearables, such as acceptance by the customers and system approvals, and disposal.

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“…Injured skin is vulnerable to bacterial infections, which can cause tissue damage, trigger a severe inflammatory response, and impede wound healing. 1 Antibiotics have been widely used to fight bacterial infections in wounds. However, the abuse of antibiotics leads to the development of antibiotic-resistant strains, which reduces the effectiveness of infected wound treatments.…”

Section: ■ Introductionmentioning

confidence: 99%

Photodynamic Alginate Zn-MOF Thermosensitive Hydrogel for Accelerated Healing of Infected Wounds

Zhang

Wang

Xiang

et al. 2023

ACS Appl. Mater. Interfaces

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Antibiotic resistance reduces the effectiveness of infected wound healing, and it is necessary to develop a new strategy to promote infected wound healing without using antibiotics. Here, we develop a Chlorin e6 (Ce6)-loaded zinc-metal−organic framework (MOF) thermosensitive hydrogel (Ce6@MOF-Gel) based on alginate and poly(propylene glycol) 407, which enhances antibacterial effects and promotes infected wound healing by a novel strategy of combining zinc-MOF with photodynamic therapy (PDT). Zinc-MOF can realize acid-responsive release of Ce6 and improve antibacterial performance without drug resistance by destroying the integrity of bacterial cell membranes and enhancing the production of bacterial reactive oxygen species (ROS). Additionally, Ce6@MOF-Gel enhances the stability, solubility, and photodynamic properties of Ce6. More importantly, Ce6@MOF-Gel reduces inflammation and promotes collagen deposition and re-epithelialization to facilitate infected wound healing. Collectively, the photodynamic MOF-based hydrogel provides a new, efficient, and safe way for accelerated healing of infected wounds.

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Electrospun Aligned PCL/Gelatin Scaffolds Mimicking the Skin ECM for Effective Antimicrobial Wound Dressings

Cited by 60 publications

References 53 publications

Highly Aligned Cellulose/Polypyrrole Composite Nanofibers via Electrospinning and In Situ Polymerization for Anisotropic Flexible Strain Sensor

Highly Aligned Cellulose/Polypyrrole Composite Nanofibers via Electrospinning and In Situ Polymerization for Anisotropic Flexible Strain Sensor

Wearable Smart Bandage-Based Bio-Sensors

Photodynamic Alginate Zn-MOF Thermosensitive Hydrogel for Accelerated Healing of Infected Wounds

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